2014 Annual Meeting Presentations

July 13 - 16, 2014
Hilton Chicago • Chicago, Illinois, U.S.A.

The CRS Annual Meeting presentation webcasts are available only to CRS members and those who attended the 2014 annual meeting for viewing.


Plenary Sessions


Drug Delivery to Promote Tissue Regeneration: How Simple is Complex Enough?
Kristi Anseth

   Redesigning Nutrition Delivery
- David Edwards

Scientific Sessions & Mini-Symposia

Advances in Drug Delivery to the Eye

Invited Speaker: Facilitated Drug Delivery to the Retina by Controlled Modulation of Permeability at the Inner Blood-retina Barrier -  Pete Humphries

Ocular delivery of a model biopharmaceutical, lacritin, using protein polymers - John MacKay

In vivo enhancement of transscleral penetration of macromolecules by low-intensity and low-frequency ultrasound - Wai-leung Suen

Injectable, Degradable and Biocompatible Poly(oligoethylene glycol methacrylate) Hydrogels - Todd Hoare

Advances in Drug Delivery to the Lung

Highly Sensitive and Selective Anti-cancer Effect by Conjugated HA-Cisplatin in CD44 Overexpression Non-small Cell Lung Cancer  - Hyun Koo Kim

A New Strategy to Enhance Antibiotic Load for Pulmonary Treatment of Cystic Fibrosis Infections: Ciprofloxacin Lipid Complex Loaded PLGA Nanoparticles - Nazende Günday Türeli

Advances in Process Engineering -- New Methods for the Production of Particles, Capsules, and Coatings

The NanoAssemblr™ Platform: Scalable, Microfluidics-based Manufacture of siRNA Lipid Nanoparticles - Colin Walsh

Designing Sustained Release Encapsulates loaded with Water Soluble Oxidant: Carbamide Peroxide - Fideline Tchuenbou-Magaia

Advances in RNA and DNA Delivery

Invited Speaker: Intracellular Signal-Responsive Carriers as New Strategy to Secure Cell Specificity in Tumor Gene Delivery - Yoshiki Katayama

A cationic nanoemulsion for the delivery of next generation RNA vaccines - Luis Brito

Versatile Platform for Sustained Gene Silencing Improves Excisional Wound Healing in Diabetic Rats - Christopher Nelson

Lipid nanoparticles for organ-specific delivery of RNA - Heinrich Haas

Breakthrough Technologies

Invited Speaker: Edible Electronics: Next generation medical devices for oral delivery - Chris Bettinger

From Laboratory to Pilot Scale: Advanced Dosage Forms of Protein/Peptide Medicines - Tuo Jin

Platform-Technology Based on Prodrug/Enzyme Systems for Rapid Absorption of Hydrophobic Drugs: Toward Intranasal Treatment of Seizure Emergencies - Mamta Kapoor

High Surface Area Porous Polypyrrole Structures for Glutamate Delivery - Darren Svirskis

Rational design of wet spun monofilaments and multifilament yarns as controlled-release drug delivery systems for biomedical applications - Danya Lavin

Cells as Delivery Vehicles

Multifunctional delivery systems for encapsulated islet cell therapy - Danya Lavin

Controlled Release Applications in Food, Feed, and Beverages

Elaboration and Characterization of Barley Protein Nanoparticles as an Oral Delivery System for Lipophilic Bioactive Compounds - Jingqi Yang

Doubled-layered emulsions as delivery systems to reduce the degradation of Coenzyme Q10 and control its release at the absorption site - Qixin Zhong

Effect of Physical Properties of Enzymatically-Modified Starch Gels on Salt Release of the Gel-Containing Water-in-Oil-in-Water Emulsions - Younglim Kim

In vitro and in vivo release of carvacrol encapsulated in Ca-alginate microspheres - Qi Wang

Controlled Release of Actives in Consumer Products

Invited Speaker: Physico-chemical Challenges of Designing Delivery Systems for Consumer and Industrial Applications - Nilesh Shah

Development and Evaluation of Resveratrol and Vitamin E Acetate-loaded Solid Lipid Nanoparticles for Skin Care Applications - Jin Chen

Efficient Ibuprofen Delivery by a Novel Semi-Solid Silicone Formulation: In-vitro and In-vivo Study - Hyder Aliyar

Biocompatible Dendritic Nanogels for Thermally Triggered Skin Penetration - Mazdak Asadian-Birjand

Influence of the vehicle type on the in-vitro skin permeation of acetyl hexapeptide-8 - Magdalena Hoppel

Evaluation and Characterization of Controlled Release Products and Production Processes

Invited Speaker: An Introduction to Dynamic Imaging Particle Analysis for Use in Controlled Release R&D and Production Environments - Lew Brown

Real time Raman imaging to understand dissolution performance of amorphous solid dispersions - Francesco Tres

The influence of  spray drying parameters on particle composition, structure and in vitro release of injectable microspheres for controlled release - Joke Meeus

Mass Spectrometry for Comprehensive Characterization of Controlled Release Systems - Ruth Schmid-Baumberger

Non-Disruptive Measurement of Encapsulation Efficiency For Hydrophobic Actives - Fanwen Zeng

Innovations in Micro-and Nano-Based Delivery

Programmable Release of a Water-Soluble Drug from Electrospun Nanofibers for HIV Inhibition - Daniel Carson

Inactivated Polio Vaccination Using a Microneedle Patch - Jessica Joyce

Innovations in Oral Drug Delivery

Invited Speaker: Oral delivery of heparin conjugate - Youngro Byun

Synergistic Effect of M Cell Targeting Peptide and Mucoadhesive Vehicle on Induction of Immune Responses in Oral Vaccine Delivery - Chong-Su Cho

Can ion pairing mediate drug uptake via active carriers? - Amr ElShaer

High-throughput, slit-surface, core-sheath electrospinning: Improving the formulation and dissolution of poorly soluble drugs - Quynh Pham

Mucus Penetrating Nanoparticles Improve Drug and Gene Delivery to the Gastrointestinal Tract - Katharina Maisel 

Intracellular Delivery of Nucleic Acids and Proteins

Nucleodendrimers for endosomal escape - Silvia Muro

The Multifaceted Role of Glycosaminoglycans in the Cellular Uptake of Cell-Penetrating Peptides - Roland Brock

Wrapping Polyplex with a Monolayer of Rationally Designed Block Copolymer for Inter- and Intra-cellular Delivery of siRNA - Tuo Jin

Mini Symposia – Advancements to Develop and Delivery Biologics

Invited Speaker: Recent Innovations in Oral Vaccine Delivery - Rosie McLaughlin

Mini Symposia – Cancer Epigenetics, Epigenetic Drugs and Delivery

Invited Speaker; Spatiotemporal delivery of epigenetic and chemotherapeutic nucleoside analogs to pancreatic cancer - Rajgopal Govindarajan

Invited Speaker: Targeting DNA hypermethylation by nanomedicine for acute myeloid leukemia therapy - Shujun Liu

Mini Symposia – Individualized Medicine and Theranostics

Invited Speaker: Nanomedicines and Theranostics: Image-guided and Targeted Treatments for Individualized and Improved Interventions - Twan Lammers

Mini Symposia - Interspecies Clinical Pharmacology Dosing Concepts

Invited Speaker: The Biopharmaceutics of Veterinary Drug Delivery - Steven Sutton

Invited Speaker: Zoological Pharmacology:  Of Mice and Elephants - Robert Hunter

Mini Symposia: Micro- and Nano-Encapsulation: From Innovation to Commercialization

Invited Speaker: The Determination of Cost and the Economics for Controlled Release Processes - Ronald Versic

Nanoparticle Based Delivery to the Brain

Invited Speaker: Dendrimer-based targeted systemic therapies for neuroinflammation in CNS disorders - Kannan Rangaramanujam

Highly compacted pH-responsive DNA nanoparticles mediate efficient transgene silencing in experimental glioma - Anthony Kim

Nanoparticles in Tumor Treatment

Invited Speaker: Nanocarrier’s Function Integration and Synchronization for Cancer Drug Delivery Cascade - Youqing Shen

Folate-conjugated PEG-derivatized Embelin as A Versatile Nanocarrier for the Targeted Delivery of Doxorubicin with Reversal of Multidrug Resistance - Jianqin Lu

Targeted Cellular Interactions of Dendron Micelles using PEG linkers - Ryan Pearson

Anticancer polymeric nanomedicine bearing synergistic drug combination - Ela Markovsky

Novel Development in Formulation, Analytical Chemistry, and Processing in Animal Health and Preclinical Sciences

Invited Speaker: Advances in Veterinary Extended Release Injectables Formed in situ and a Case Study - Susan Cady

Investigation into the Topical Delivery of Diclofenac into Equine Skin - Sergio del Rio-Sancho

Examination of Polymer Swelling and API Release of Controlled Release Formulations at the Solid-Liquid Interface by UV Surface Imaging - Christopher Zordan

Nano-Emulsions for Biomedical Imaging - Thierry Vandamme

Overcoming Barriers in the GI Tract

A biomimetic strategy for gastric targeting based on Helicobacter pylori - Naim Hage

Nanostructured lipid-based mucoadhesive particles formed from pH responsive vesicles - Ben Boyd

Intestinal mucosa permeability following oral delivery of wheat germ agglutinin non-sheddable nanocage stabilized nanocrystals - Dengning Xia

Overcoming Biological Barriers

Bypassing Endocytosis Size-Restrictions - Silvia Muro

Predictive Animal Models for Assessing Long-Acting Formulations for Human and Animal Health and Their Challenges

Invited Speaker: Models for Predicting Functional Response to Drug and Vaccine Delivery To and Through Skin - James Birchall

Composite Coatings to Suppress the Foreign Body Response in a Large Animal Model - Michail Kastellorizios

Proteins, Peptides, and Vaccines

Bone-Targeting Parathyroid Hormone Analogues Outperform Unmodified PTH in the Anabolic Treatment of Osteoporosis in Rats -  Yang Yang

RNAdjuvant®, a novel RNA-based immunomodulator, combines strong immunostimulatory capacities with a favourable safety profile - Patrick Baumhof

Enhanced DNA vaccination using microsphere/polyplex-releasing multi-layered microneedles - Nak Won Kim

Transdermal Delivery

Invited Speaker: Improving The Reach Of Vaccines To The Developing World With Nanopatches - Mark Kendall

Tyrosine-derived Nanospheres (TyroSphereTM): A New Carrier System for Topical Delivery of Adapalene - Tannaz Ramezanli

Transdermal Nanographene Oxide - Hyaluronic Acid Conjugate for Photothermal Ablation Therapy of Skin Cancer - Sei Kwang Hahn

Delivery of recombinant human epidermal growth factor via hair follicles with a nano liposome system - Sangkil Lee


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