Local Delivery of Anti-Apoptotic BNIP3 siRNA by BioreduciblePolymers Retains Heart Function after Myocardial Infarction in Rats

A. McGinn1,2, D. Bull3, and S. W. Kim2

1University of Utah, Salt Lake City, Utah, 84112,USA, Department of Pharmacology and Toxicology; 2University of Utah, Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry; 3University of Utah, Department of Surgery, Cardiothoracic Division


A novel bioreducible polymer was used to transfect rat hearts with anti-apoptotic siRNA in vivo immediately after transient myocardial infarction. siRNA towards BNIP3, a potent hypoxia-inducible pro-apoptotic Bcl-2 family member, was delivered directly to the infarcted myocardium of Sprague Dawley rats. siBNIP3 therapy in this model protected rats from loss of heart function as evidenced by global left ventricular ejection fraction and chamber volume.


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