Nano-Structured Microparticles for Prolonged Residence Time on Preocular Surface

Chun Gwon Park1, Min Park1, Ji Eun Lee1, SeungHo Lee1, Gyeong-Seon Shin2 and Young Bin Choy*, 1, 2, 3

1Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 152-742,

Republic of Korea

2Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea

3 Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 110-799, Republic of Korea


Topical drug administration is widely accepted for treatment for ocular diseases, which, however, is limited in low drug bioavailability due to rapid clearance from the preocular surface. Therefore, in this work, we proposed the microparticles designed with nano-structured surface (NM) as a potential drug carrier for ocular delivery. For this purpose, nanofibrous sheets of poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) as a wall material and mucoadhesion promoter, respectively, were freeze-milled to give the NM of large surface area, hence prolonged preocular retention. In vivo animal study revealed that more than a half of the NM with PEG still resided on the preocular surface 10 min after administration while more than 70% of the other types of microparticles disappeared.

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