Induction and Targeting of the Heat Shock Response in Prostate Cancer

N. Larson 1,2, A. Gormley2,3, S. Sadekar1,2, R. Robinson2,3, A. Ray1,2, H. Ghandehari1-3

1Department of Pharmaceutics and Pharmaceutical Chemistry, 2Utah Center for Nanomedicine, Nano Institute of Utah, and 3Department of Bioengineering, University of Utah, Salt Lake City, UT, 84108, USA

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Summary
This study demonstrates a drug delivery strategy in which: 1) the expression of glucose regulated protein 78 kDa (GRP78, a member of the heat shock protein 70 family of proteins) is specifically induced on the surface of cancer cells, and 2) delivery of a chemotherapeutic agent is enhanced using a polymeric carrier designed to target this induced expression. It is anticipated that such a strategy can increase the specific delivery of chemotherapeutic agents to tumor tissues.

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