A guanidine-substituted polyamidoamine with outstanding antiviral activity against Herpes Simplex Virus, Papilloma Virus, Cytomegalovirus and probably other DNA viruses

Paolo Ferruti1, David Lembo2, Manuela Donalisio2, Elisabetta Ranucci1, Amedea Manfredi1 and Roberta Cavalli3

1Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy; 2Dipartimento di Scienze Cliniche e Biologiche, Ospedale S. Luigi Gonzaga, 10043 Orbassano, Torino, Italy; 3Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, via P. Giuria 9, 10125 Torino, Italy

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Summary
An amphoteric biocompatible polyamidoamine with guanidine side substituents proved very active in vitro and in vivo against HSV and other DNA viruses without eliciting adverse side effects.

 

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