Patrick Midoux 1, Cristine Gonçalves1, Jean-Pierre Gomez1, Bazoli Rasolonjatovo3, Tony Le Gal2, Tristan Montier2, Pierre Lehn2, Chantal Pichon1, Philippe Guégan3, Hervé Cheradame3.

1Centre de Biophysique Moléculaire, CNRS UPR4301 and Université d’Orléans, France; 2INSERM U613, Hôpital Morvan - CHU Brest - I3S, Brest, France; 3Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement, CNRS UMR8587 Université d'Evry Val d'Essonne, Evry, France


A new triblock poly (2-methyl-2-oxazoline-btétrahydrofurane- b-2-methyl-2-oxazoline) copolymer have been used to solubilize curcumin in water. When used on F508-CFTR cells lines, curcumin-loaded with this triblock copolymer (BR04) induces a restoration of the expression of the mutated CFTR protein in the plasma membrane. This restoration is correlated with the functionality of the redistributed CFTR chloride channel in the plasma membrane. These results show a great potential of triblock copolymers for Cystic Fibrosis treatment.


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