Evaluation of Antibiotic-releasing Porous Polymethylmethacrylate Space Maintainers in an Infected Composite Tissue Defect

P.P. Spicer1, A.M. Henslee1, L.A. Kinard1, B.M. Watson1, J.D. Kretlow2, K. Bevil1, L. Katchee1, J.A. Jansen3, M.E. Wong4, F.K. Kasper1, A.G. Mikos1
1Rice University, Houston, Texas, 77005, USA; 2Baylor College of Medicine, Houston, Texas, 77030, USA; 3Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands; 4University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA


Antibiotic releasing porous space maintainers were evaluated in an infected rabbit mandibular composite tissue defect model. Temporal release and magnitude of release were varied to evaluate their effects on clearance of the infection, soft tissue healing and inflammatory response. Additionally the safety of the local delivery was measured via serum blood markers for kidney function and histology. Results showed an effect on gross soft tissue healing in response to temporal delivery changes and local delivery resulted in no decreased kidney function as measured by serum markers.

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