Ultrasound-Induced Release from eLiposomes at 20 kHz

William G. Pitt1 and James R. Lattin1
1Brigham Young University, Provo, Utah, 84602, U.S.A.


This work describes a novel ultrasound sensitive drug delivery system that utilizes perfluorocarbon emulsion droplets encapsulated inside of a lipid membrane. This structure has been named an eLiposome. Calcein was used as a model drug, and drug release upon sonication was determined by fluorescence techniques. Release increased with insonation time and intensity. eLiposomes have great potential for spatially controlled drug delivery. 

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