2012 CRS Annual Meeting Presentations

July 15 - July 18, 2012 • Centre des congres de Québec • Québec City, Canada

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Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization

Invited Speaker: Imaging Techniques for the Characterisation of Advanced Delivery Systems and Biomedical Systems; Martyn Davies
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Relating the influence of temperature and humidity on the surface characteristics of a spray-dried polymeric matrix consisting of poly(lactic-co-glycolic acid) and polyvinylpyrrolidone to the thermal characteristics of these polymers; Joke Meeus
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Confocal Raman microscopy as a novel approach for development and chemically resolved characterization of a drug permeation model; Birthe Kann
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Bioactive Materials/C&DP: Nanofibers/Nanoparticles

Nano-Structured Microparticles for Prolonged Residence Time on Preocular Surface; Chun Gwon Park
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Polymeric Nanofibers Co-loaded with Fusidic Acid & Rifampicin for the Prevention of Implant Associated Infections; Samuel Gilchrist
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Bioactive Materials/Veterinary: Protein and Vaccine Delivery

Invited Speaker: Uniform PLGA Microspheres Sustain NSAID Blood Levels With Zero-Order Kinetics; Cory Berkland
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Engineered Pathogen-like Particle Subunit Vaccines Induce Robust, TH1-Biased Immunity; Joseph Rosenthal
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PTHrP to Prevent Curve Progression in a Novel Murine Model of Early Onset Scoliosis; Michael Sullivan
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Bioactive Materials: Biomaterials

Curcumin; Patrick Midoux
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A guanidine-substituted polyamidoamine with outstanding antiviral activity against Herpes Simplex Virus, Papilloma Virus, Cytomegalovirus and probably other DNA viruses; Paolo Ferruti
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Bioactive Materials: DNA and RNAi Delivery

Local Delivery of Anti-Apoptotic BNIP3 siRNA by BioreduciblePolymers Retains Heart Function after Myocardial Infarction in Rats; Arlo McGinn
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High-content screening of peptide-based non-viral gene delivery systems; Markus de Raad
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Bioactive Materials: Drug Delivery to the Brain

Invited Speaker: The blood-brain barrier, a bridge too far?; Laurent Lecanu
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PET-based approaches to studying the size-dependence of leptomeningeal drug clearance; Elena Belova
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Bioactive Materials: Inorganic Nanosystems

Target Specific Systemic Delivery of siRNA and Interferon a Using Gold Nanoparticles for the Treatment of Liver Diseases; Min-Young Lee
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Nanocomposites Based On Montorillonite, Chitosan And Silver Sulfadiazine Intended For Wound Healing; Carla Caramella
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In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface charge; Tian Yu
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Bioactive Materials: Intracellular Processes 

PLGA micro or nanoparticles differently induce inflammatory response in murine macrophages; Roberto Nicolete
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New insight of microbubbles-cell interactions during sonoporation process; Lucie Pigeon
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Intercellular transfer of nano and micro-particles in endothelial cells; Silvia Ferrati
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Bioactive Materials: Nanomedicines

Induction and Targeting of the Heat Shock Response in Prostate Cancer; Nate Larson
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Flt1 Peptide - Hyaluronic Acid Conjugate Micelle-Like NanoparticlesEncapsulating Genistein for the Treatment of Occular Neovascularization; Hyemin Kim
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Recombinant Cell Penetrating Peptide Construct for Targeting Mildly Acidic pH; Likun Fei
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Bioactive Materials: Oncology and Tumor Targeting

Invited Speaker: Design of a produg of mitomycin C for liposomal delivery: From bench to bedside; Alberto Gabizon
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Electrophoretic Disruption of Nonspecific Peptide Interactions with MMP-Sensitive Hydrogels; Richard Gemeinhart
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Development of novel tumoral pH responsive nanoparticles for cancer therapy; Susumu Hama
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Bioactive Materials: Oral Controlled Release

Invited Speaker: Exploiting the Biology of Microbial Toxins for Protein Delivery; Randall Mrsny
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Oral disposition of G3.5 PAMAM dendrimer across mice intestinal epithelia and anticancer activity of its drug conjugate; Giridhar Thiagarajan
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Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus; Yuan Huang
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Tailored Controlled Release by Printing of Drug Substances and Polymer Layers; Niklas Sandler
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Foam Hot Melt Extrusion of an Eudragit - Nifedipine Matrix Formulation using Supercritical CO2; Tony Listro
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Bioactive Materials: Stem Cell and Regenerative Medicines

Thermoreversible hydrogels as a Drug Release Platform in Degenerative Disc Disease; Jacco Eversdijk
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Controlled Release of Bioactive PDGF-AA from PLGA Nanoparticles; Irja Elliott Donaghue
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Evaluation of Antibiotic-releasing Porous Polymethylmethacrylate Space Maintainers in an Infected Composite Tissue Defect; Patrick Spicer
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Bioactive Materials: Theranostics and Cancer Nanotechnologies

Invited Speaker: Carbon Nanotubes for Theranostic Applications; Xiaoyuan Chen
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Tumor Cell-Specific Delivery of Paclitaxel Using a Self-assembled Matrix Metalloprotease 2-sensitive Nanocarrier; Lin Zhu
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Ultrasound-Induced Release from eLiposomes at 20 kHz; William Pitt
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Gas-Generating Calcium Carbonate Mineralized Nanoparticles for Ultrasound Imaging; Kyung Hyun Min
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Bioactive Materials: Transdermal Drug Delivery

Invited Speaker: Improving the Bioavailability of Topically and Transdermally Delivered Drugs; Richard Guy
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Localized Drug Delivery through Mammary Papilla; Kaushalkumar Dave
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Bioactive Materials: Translational Nanomedicine

In vivo assessment of salmon calcitonin nanoparticles delivered by the intra-articular route for treatment of inflammatory arthritis in the K/BxN mouse model; David Brayden
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Loperamide-Formulated Immunoliposomes Directed Towards Intercellular Adhesion Molecule-1 (ICAM-1): A Potential Tool for Specific Drug Delivery to Peripheral Inflammatory Pain; Susan Hua
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PLGA Nanoparticle Property-Biodistribution Relationships and In Vivo Degradation; Joshua Reineke
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C&DP: Consumer and Industrial Applications of Nanoparticle Technology

Invited Speaker: Advances of Sub-micron Particle Technologies for Consumer and Industrial Applications; Fanwen Zeng
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Improvement of In Vitro Efficacy of Ascorbyl Glucoside by Encapsulation in QD Compliant Cationic Liposome; Florent Durieux
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Encapsulated liquid lubricants for production of self-lubricating surfaces; Ruth Schmid
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C&DP: Fragrances and Flavors

Invited Speaker: Microencapsulation Using Fluid Bed System and Prilling Techniques, Concepts to Realities, Factors Associated with Process Development; Laurence Lee
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Micromanipulation and Finite Element Analysis to Determine the Mechanical Strength of Perfume Microcapsules; Zhibing Zhang
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Compritol; 888 ATO Lipid Matrices for Sustained Release Processed by Hot-Melt Extrusion; Dennis Douroumis
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C&DP: Hydrogel Delivery Systems in Consumer Products

Invited Speaker: Contact Lenses for Delivery of Drugs to the Front and Back of the Eye; H Sheardown
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Extended Release of DMPC from Silicone Hydrogel Contact Lenses; William Pitt
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Increased release time of diclofenac loaded into a cross-linked hyaluronic acid hydrogel; Ole Dall
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C&DP: Nutraceuticals and Functional Foods

Invited Speaker: Keynote Address, Neutricueticals and Functional Foods; Howard Wheeler
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Determination for Moisture Permeation in Film Coating; Brian Cheng
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The Influence of Calcium Carbonate in Tablet Coating Systems; Beverly Schad
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Multilayer alginate-chitosan microcapsules for the effective oral delivery of probiotic Bifidobacterium; Michael Cook
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Mini Symposia: Active Targeting vs. Passive Targeting

Invited Speaker: Active vs Passive Targeting of Drug Delivery Systems: Opportunities and Pitfalls; Theresa Allen
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Invited Speaker: Drug Targeting to Tumors: To Actively Target, or Not to Actively Target?; Gert Storm
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Mini Symposia: New Chemistries - Click It, Fit It, Test It

Invited Speaker: Nanoscale Amphiphilc Macromolecules: Designing compounds to inhibit oxidized low-density lipoprotein uptake; Kathryn Uhrich
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Mini Symposia: Recombinant Polymers - Macromolecules from Microbes

Invited Speaker: Protein Polymers and Their Design and Production for Medical Applications; Joseph Cappello
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Veterinary: Protein and Peptide Therapeutics for Animal Patients

Quantitation of sustained release of triptorelin in beagle dog plasma by liquid chromatography-tandem mass spectrometry; Wanhui Liu
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