A Drug Transport Model for Delivery Vectors Incorporating Chemical and Microstructure Properties

M. Kojic1, M. Milosevic2, N.Kojic3, M.Ferrari1, A. Ziemys1

1 The Methodist Hospital Research Institute, Houston, TX 77030, USA; 2 R & D Center for Bioengineering, 34000 Kragujevac, Serbia; 3 Harvard Medical School, Boston, MA 02114

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Summary
The release of drugs by diffusion is affected by drug interactions with the vector matrix and material microstructure of drug vectors. Here we present our recently developed multiscale model for diffusion in materials with complex structure and physico-chemical properties showing superiority over classical approaches. The robustness of the method is demonstrated on validated examples with nanochannel-based drug vectors and diffusion through polymers.

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