Drug Imaging in Novel Geometric Three-layered Tablet Using Various Physical Properties and Raman Spectroscopy

Duhyung Choi1, Kihyun Kim2, Daegon Lim2 and Seong Hoon Jeong2*

1College of Pharmacy, Pusan National University, Busan, 609-735, Republic of Korea 2College of Pharmacy, Dongguk University-Seoul, Gyeonggi, 410-820, Republic of Korea


A novel geometric system consisting of an inner immediate release mid layer and two extended release barrier layers with swellable hydrophilic polymers was investigated for once-a-day formulation.1 In this system, aqueous medium rapidly penetrates to the mid layer of water-soluble excipients and the two barrier layers swell to wrap the mid layer. Considering these geometric properties of this system, various physical properties were evaluated for drug release monitoring and also Raman imaging was used for real-time imaging of the drug release.

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