Multistage Vector for Controlled Oral Delivery of Anti-Inflammatory Drug in Inflammatory Bowel Disease Treatment

F. Leonard1,2,3, E.-M. Collnot2,3, C.-M. Lehr2,3, M. Ferrari1 and B. Godin1

1Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, 77030, USA; 2Helmholtz Institute for Pharmaceutical Research Saarland; and 3Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, 66123, Germany

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Summary
A multistage nanodelivery vehicle was developed by loading of budesonide containing poly(lactic-coglycolic acid) (PLGA) nano-particles into silicon nanoporous microparticles. The combination of micro- and nanoparticles utilizes each of the strengths of each component to be employed in oral drug delivery to inflammatory bowel disease (IBD). Drug efficiency was tested in a recently reported by us in vitro model of IBD.

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