Multi-functional cationic dendrimers for connexin43 antisense oligodeoxynucleotide delivery in the treatment of wet age-related macular degeneration

I. D. Rupenthal1, A. Stikkelman1, I. Toth2 and C. R. Green1

1Department of Ophthalmology, The University of Auckland, Auckland, New Zealand; 2School of Chemistry and Molecular Biosciences and School of Pharmacy, University of Queensland, Brisbane, Australia

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Summary
Retinal delivery of genetic material is limited by the molecules’ stability and cellular uptake. This study investigated seven multi-functional dendrimer carriers for their ability to form complexes with connexin43 (Cx43) antisense oligodeoxynucleotides (AsODN) and efficiently deliver these molecules into retinal pigment epithelium cells with minimal cytotoxicity.

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