Tumor-Microenvironment-On-Chip: Simulation of Complex Transport around Tumor

Bongseop Kwak1, Kinam Park2, 3, and Bumsoo Han1, 3

1School of Mechanical Engineering; 2Department of Pharmaceutics; 3Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA


A new tumor model is developed using microfluidics and tissue engineering technology in order to simulate the complex in vivo tumor microenvironment including vasculature, interstitium and lymphatics. The developed model, referred as to the tumor-microenvironment-onchip (TMOC), can mimic highly dynamic, interconnected and spatiotemporally varying tumor microenvironment and allows systematic characterization of nanoparticles (NPs) transport around tumors.

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