Effect of Supercritical Carbon Dioxide on Hot Melt Extruded Cellulose Polymers

Michael A. Repka1, 2, Eman A. Ashour1, Sejal Shah1, Soumyajit Majumdar1, 2, Ray Bosworth3, Majid Keshtmand3 Vivian Bi4, Tom Durig4

1Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS-38677, USA 2Pii Center for Pharmaceutical Technology, School of Pharmacy, The University of Mississippi, University, MS-38677, USA 3Ashland Specialty Ingredients, Solubilization Center of Excellence, Columbia, MD 21045, USA 4Ashland Specialty Ingredients, Wilmington, DE 19808 USA

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Summary
The aim of the current research project was to study the effect of supercritical carbon dioxide (SC-CO2) on the physico-mechanical properties of cellulose polymers, Klucel LF, EF and ELF hydroxypropylcellulose (HPC) resulting from hot melt extrusion techniques, and to assess the plasticization effect of SC-CO2 on the polymers tested. The physico-mechanical properties as well as the tablet characteristics of the extrudates with and without injection of SC-CO2 and with pure polymers were examined. SC-CO2 acted as plasticizer for Klucel LF, EF and ELF and allowed for a reduction in processing temperature during the extrusion process. Bulk and tap density as well as surface area and pore volume of the extrudates processed with SC-CO2 increased compared to the extrudates processed without SC-CO2. Furthermore, the hardness of the tablets of the polymers with SC-CO2 was increased. Thus good binding properties and compressibility of the extrudates were positively influenced utilizing SC-CO2 processing.

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