Nanogels as a Platform for Targeted Delivery of Cisplatin to the Brain Tumor

N.V. Nukolova1,2, V.P. Baklaushev1,3, A.S. Khalansky4, G.M. Yusubalieva1, I.L. Gubskiy3, T.O. Sandalova1, A.V. Kabanov2,5, V.P. Chekhonin1,3

1Serbsky National Research Center for Social and Forensic Psychiatry, Moscow, 119991, Russia; 2Lomonosov Moscow State University, Department of Chemistry, Moscow, 119991, Russia; 3Russian State Medical University, Moscow, 117997, Russia; 4Research Institute of Human Morphology of the Russian Academy of Medical Sciences, Moscow, 117418, Russia; 5Center for Nanotechnology in Drug Delivery and Division of Molecular Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7362, USA

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Summary
This study demonstrated the tumor-specific drug delivery and superior anti-tumor effect in vivo of an anti-cancer drug using polyelectrolyte nanogels conjugated with monoclonal antibodies. These nanogels could be used as a platform for the targeted delivery of chemotherapeutic agents to the tumors.

 

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