N.V. Nukolova1,2, V.P. Baklaushev1,3, A.S. Khalansky4, G.M. Yusubalieva1, I.L. Gubskiy3, T.O. Sandalova1, A.V. Kabanov2,5, V.P. Chekhonin1,3
1Serbsky National Research Center for Social and Forensic Psychiatry, Moscow, 119991, Russia; 2Lomonosov Moscow State University, Department of Chemistry, Moscow, 119991, Russia; 3Russian State Medical University, Moscow, 117997, Russia; 4Research Institute of Human Morphology of the Russian Academy of Medical Sciences, Moscow, 117418, Russia; 5Center for Nanotechnology in Drug Delivery and Division of Molecular Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7362, USA
This study demonstrated the tumor-specific drug delivery and superior anti-tumor effect in vivo of an anti-cancer drug using polyelectrolyte nanogels conjugated with monoclonal antibodies. These nanogels could be used as a platform for the targeted delivery of chemotherapeutic agents to the tumors.