Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

P. Marizza1, S. S. Keller1, T. Rades2, A. M├╝llertz2, I. Kikic3, M. Moneghini4, N. De Zordi4, D. Solinas3, A. Boisen1

1Department of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Copenhagen, 2800, Denmark; 2Institute of Pharmacy and Analytical Chemistry, University of Copenhagen, 2100, Denmark 3Department of Engineering and Architecture, University of Trieste, 34100 Italy 4Department of Chemical and Pharmaceutical Sciences, University of Trieste, 34100 Italy

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Summary
In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

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