Nanoparticulate Delivery to the Skin by exploiting Passive Physical Principles

R. H. Müller1 and C. M. Keck2

1Pharmacy Department, Free University, Berlin, 12169, Germany; 2PharmaSol GmbH, Berlin, 12307 Berlin, Germany

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Summary
Increasing dermal penetration/permeation is still a challenge for many cosmetic actives and drugs. An overview is presented to exploit physical principles for delivery improvement, e.g. ranging from simple occlusion to generated supersaturation effects. The principles are exploited in combination with dermal nanocarriers. In contrast to chemical enhancers, these principles have no/little regulatory hurdles.

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