Silk-based Biomaterials for Stabilization and Sustained Release of Neutraceuticals

Xiaoqin Wang1,2, Amanda R. Murphy2, Zhaozhu Zheng1, Tinging Luo1, and David L. Kaplan2
1InstitutionNational Engineering Laboratory for Modern Silk (NESER), Suzhou, Jiangsu, 215123, China; 2Biomedical Engineering Department, Tufts University, Medford, Massachusetts, 02155, USA


Silk fibroin material in a form of waterinsoluble film was used as a stabilization and sustained release matrix to incorporate neutraceuticals, such as curcumin from Curcuma longa. Curcumin release kinetics, distribution, and biological activities to regulate cell growth and differentiation were examined. It was found that curcumin was stably released at a low level for more than 4 weeks from silk matrix, which promoted adipogenic differentiation of human mesenchymal stem cells (hMSCs).

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