Ischemic Myocardium Targeting Peptide-guided Gene Delivery System

Young-Wook Won 1, Arlo N. McGinn 1, Minhyung Lee 2, David A. Bull 3, Sung Wan Kim 1,2

1 Center for Controlled Chemical Delivery (CCCD), Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA; 2 Department of Bioengineering, Hanyang University, Seoul, 133-791, Republic of Korea; 3 Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of Utah, Salt Lake City, UT, 84112, USA

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Summary
Gene therapy for myocardial ischemia is limited due to inadequate transfection in cardiomyocytes and difficulty in directing to ischemic myocardium. Here, we present a polymeric gene carrier that is capable of targeting ischemic myocardium, resulting in high localization within the ischemic zone of the left ventricle (LV) of a ischemia/reperfusion (I/R) rat model upon systemic administration. This study provides a clue that gene therapy for the treatment of myocardial ischemia can be achieved by using homing peptide-guided gene delivery systems.

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