Ischemic Myocardium Targeting Peptide-guided Gene Delivery System

Young-Wook Won 1, Arlo N. McGinn 1, Minhyung Lee 2, David A. Bull 3, Sung Wan Kim 1,2

1 Center for Controlled Chemical Delivery (CCCD), Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA; 2 Department of Bioengineering, Hanyang University, Seoul, 133-791, Republic of Korea; 3 Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of Utah, Salt Lake City, UT, 84112, USA


Gene therapy for myocardial ischemia is limited due to inadequate transfection in cardiomyocytes and difficulty in directing to ischemic myocardium. Here, we present a polymeric gene carrier that is capable of targeting ischemic myocardium, resulting in high localization within the ischemic zone of the left ventricle (LV) of a ischemia/reperfusion (I/R) rat model upon systemic administration. This study provides a clue that gene therapy for the treatment of myocardial ischemia can be achieved by using homing peptide-guided gene delivery systems.

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