Controlled Release of Poorly Soluble Drugs via Hot Melt Extrusion

Zhuoyang “John” Lian1, Adam Bell1, Divya Tewari1, Christian Seiler2, Abdenour Djemai2 and Thomas Dürig1

1Ashland Specialty Ingredients, Wilmington, DE 19808 USA; 2Pharmaceutical Sciences & Clinical Supply, Merck Sharp Dohme Ltd., Hoddesdon, UK


This study investigates the feasibility of hot melt extrusion (HME) combining polyvinylpyrrolidone with thermoplastic water soluble polymer hypromellose as a technique to simultaneously enhance solubility of poorly soluble drugs and facilitate the production of sustained release pellets that deliver the drug payload in a time frame of 8 hours.

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