2013 CRS Annual Meeting Presentations

July 21 - July 24, 2013 • Hawaii Convention Center • Honolulu, Hawaii, U.S.A.

The CRS Annual Meeting presentation webcasts are available only to CRS members and those who attended the 2013 annual meeting for viewing.

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2013 CRS Plenary Sessions

Human B-Lymphocytes as a Source of High-Affinity, Really Fully Human Antibodies; Kenzo Takada
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Preventing influenza, treating diabetes and preserving vision: case studies in translation of microneedle technology; Mark Prausnitz
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Challenges Around Brain Delivery: Sampling Site Issues and Interspecies Extrapolations

Nanogels as a Platform for Targeted Delivery of Cisplatin to the Brain Tumor
Natalia Nukolova
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Targeted Nano-NRTI Formulations for Suppression of HIV-1 Infection in the Brain
Serguei Vinogradov
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Drug Combination Products

Engineering Nano-scale Carriers to Coordinate the In Vivo Delivery of Anticancer Drug Combinations; Lawrence Mayer
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Drug Delivery for Developing Countries/Global Challenges

An improved claudin-targeting mucosal vaccine using a double alanine-substituted mutant of the Cterminal fragment of Clostridium perfringens enterotoxin; Mayo Yamashita
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Development and Characterization of Emulsomes for Macrophage Targeted Multidrug Therapy against Tuberculosis; Yashwant Pathak
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Vaginal Ring Configurations for the Simultaneous Delivery of Dapivirine and Levonorgestrel; Susan Fetherston
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Drug Targeting, Pharmacokinetics, and Biodistribution: Differences Between Species

Drug targeting, Pharmacokinetics and Biodistribution: Differences between species
James Klostergaard
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PBPK Modeling of the Nanoparticle Biodistribution: Interspecies Extrapolation and Tumor Targeting
Joshua Reineke
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Hyaluronic Acid – Gold Nanoparticle / Interferon α Complex for Targeted Treatment of Hepatitis C Virus Infection
Sei Kwang Hahn
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Emerging Technologies

Cationic Amphiphilic Macromolecules (CAMs)-Lipid Complexes for Intracellular siRNA Delivery; Kathryn Uhrich
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Stem Cell Derived Nano-Vesicles, A New Delivery Platform for Cancer Targeted Therapy; Naama Toledano Furman
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Energy: Problems Within the Industry That Controlled Delivery Can Solve

Controlled Release of Tracer Compounds for Inflow Monitoring in Oil Wells; Anne Dyrli
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High Temperature Phase Change Materials; James Oxley
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Novel Composite Microencapsulated Phase Change Tablet; Jo Darkwa
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Food, Nutraceuticals, and Personalized Diet

Silk-based Biomaterials for Stabilization and Sustained Release of Neutraceuticals
Xiaoqin Wang
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Hybrid Groups: Bridging the Gap Between Industry and Academia

Connecting Academia and Pharmaceutical Industry – A Max Planck Initiative Toward Closing the Innovation Gap in Drug Discovery; Bert Klebl
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Funding Translational Research in Academia; Patrick Griffin
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Transforming Discovery into Opportunity - The Centre for Drug Research and Development (CDRD) and New Models for Commercialization; Karimah Es Sabar
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Imaging and Characterization Techniques for Drug Delivery: Systems and Targeted Drug Delivery

CT/Optical Liposomes for High Accuracy Tumor Resection Using Image-Guided Surgery; Jinzi Zheng
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Direct Multi-nuclear Magnetic Resonance Imaging Studies of Controlled Drug Release; Charlie Chen
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New Applications of UV Imaging in Stability Testing: Release of Drug from Coated Particles in Pediatric Semi-Solid Dosage Forms; Daniel Bar-Shalom
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Noninvasive in vitro and in vivo Monitoring of Drug Delivery Processes by Electron Spin Resonance, Benchtop-NMR and Multispectral Optical Imaging; Karsten Mäder
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Tumor-Microenvironment-On-Chip: Simulation of Complex Transport around Tumor; Kinam Park
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Micro- and Nanoparticle Design

Activation of An Immune-Regulatory Macrophage Response and Inhibition of Lung Inflammation in A Mouse Model of COPD Using Porous Alpha B-crystallin-Loaded PLGA Microparticles; Maryam Amidi
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Multistage Vector for Controlled Oral Delivery of Anti-Inflammatory Drug in Inflammatory Bowel Disease Treatment; Fransisca Leonard
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Precision fabrication of emulsion-templated structures for encapsulation and release using microfluidics; David Weitz
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Modern Agriculture and Aquaculture

Historical Perspective on Coating Technology in Agriculture/Aquaculture
Charles Frey
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Water activity, pre-wetting and survival of Pseudomonas sp. ADP immobilized onto zeolite
Craig Bunt
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Nanoparticles and Cancer

Development of Hybrid Silica Nanoparticle Platforms: Design, evaluation and translation from lab to clinic; Michelle Bradbury
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Oral CR - Pharmaceutical Formulations, Technologies, and Development Strategies

Controlled Release of Poorly Soluble Drugs via Hot Melt Extrusion; Zhuoyang Lian
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Oral CR - Predictive Tools (In Vitro/In Vivo/In Silico)

Drug Imaging in Novel Geometric Three-layered Tablet Using Various Physical Properties and Raman Spectroscopy; Duhyun Choi
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Novel orally swallowable IntelliCapTM device guarantee success in MR development by quantitative determination of regional drug absorption in man; Dieter Becker
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Parenteral Sustained Release Drug Delivery

A Drug Transport Model for Delivery Vectors Incorporating Chemical and Microstructure Properties; Arturas Ziemys
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Anastrozole loaded-PLGA microspheres as a novel therapy to overcome noncompliance issues on breast cancer patients; Hongkee Kim
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Enhanced Exposure of a Chemotherapeutic Drug to the Lymphatic System with the use of PEGModified and Nano-Sized Drug Carriers; Gemma Ryan
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Peptide and Protein Delivery

Arginine-rich cell-penetrating peptides – The role of heparan sulfate in uptake; Rike Wallbrecher
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Development and Phase 1 Clinical Results for BA058-coated Microneedles for the Treatment of Osteoporosis; Daniel Dohmeier
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Personal and Home Care

In-vitro Method for Quantification of Fragrance Capsules Leakage in Personal Care Products
Claudio Ortiz
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Smart Microcapsules containing Enzymes for Laundry Applications
Parshuram Shukla
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Processing Technology/Manufacturability

Controlled Release from Core-Sheath Microfibers Fabricated Using a Novel High-Throughput Electrospinning System; Toby Freyman
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Influence of tableting on the conformational and thermal stability of a model protein drug; Marten Klukkert
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Integrating Delivery Device Capability into Pharmaceutical Product Development and Manufacturing; Beth Hill
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Preparation and evaluation of a novel liposomal cyclosporin A using the supercritical fluid method; Pankaj Karn
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The NanoAssemblr Platform: Microfluidics-based Manufacture of Limit Size Lipid Nanoparticles for Drug and Nucleic Acid Delivery; Colin Walsh
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Regional Delivery: Challenges in Ocular Delivery and Pulmonary Delivery

Efficacy Testing of Montelukast Loaded Large Porous Particles in Allergen-Induced Rat Asthma Model; Brijeshkumar Patel
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Evaluation of a Novel Lipid Based Nanoparticulate System for Ocular Drug Delivery; Ali Seyfoddin
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Multi-functional cationic dendrimers for connexin43 antisense oligodeoxynucleotide delivery in the treatment of wet age-related macular degeneration; Ilva Rupenthal
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Systemic Availability and in vivo Stability of PEGylated Poly-Lysine Dendrimers Following Pulmonary Delivery is Highly Size Dependent; Gemma Ryan
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Rising Suns in Asia

Enhanced Gene Expression, Transfection and Reduced Cytotoxicity of Novel Hyaluronic Acid-PEICyclodextrin Polyplexes; Sanyog Jain
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Polyspermine imidazole-4, 5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA; Shiyue Duan
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RNAi and DNA Delivery

A flexible nano carrier for siRNA delivery into tumor; Kentaro Kogure
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Ischemic Myocardium Targeting Peptide-guided Gene Delivery System; Young-Wook Won
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Noncovalenly PEGylated Ternary Complex for Pulmonary Delivery of Therapeutic siRNA; Won Ho Kong
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Sequence-Defined Multifunctional Carriers for Targeted siRNA Delivery; Ernst Wagner
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Smart Building and Construction Materials and Coatings

Crack-mediated Release of Encapsulated Bacteriabased Agent Makes Concrete Selfhealing
Henk Jonkers
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Pelletized Phase Change Material for Energy-Efficient Buildings
Ramin Abhari
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Microencapsulation of Salts for Enhanced Thermochemical Storage Materials
Nicole Papen-Botterhuis
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Microcapsule Delivery Systems for Textile Applications
Teresa Virgallito
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Solubilization Technology: A Key Enabler for the Delivery of Poorly Soluble Drugs

Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation; Paolo Marizza
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Effect of Supercritical Carbon Dioxide on Hot Melt Extruded Cellulose Polymers; Michael Repka
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Enhanced Bioavailability of Poorly Soluble Drugs by Co-spray Drying with Mesoporous Materials; Shoucang Shen
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Solubilization Technology - A Key Enabler for the Delivery of Poorly Soluble Drugs; Ravi Shanker
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Topical/Transdermal Drug Delivery

Nanoparticulate Delivery to the Skin by exploiting Passive Physical Principles; Rainer Müller
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Rapid Skin Permeabilization by the Simultaneous Application of Dual-Frequency Ultrasound; Carl Schoellhammer
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