Designing Sustained Release Encapsulates loaded with Water Soluble Oxidant: Carbamide Peroxide

Fideline L. Tchuenbou-Magaia1, James Gwyer2, Nigel Young2 and Zhibing Zhang1

1University of Birmingham, School of Chemical Engineering, B15 2TT, UK
2 Philips Research Laboratories CB4 0FY, UK

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Summary
Carbamide peroxide (CP), a hydrogen peroxide (HP) releasing agent has been encapsulated as a model active of water soluble, sensitive and reactive active. A screening of commonly used encapsulation techniques placed spray cooling of solid CP as the most promising cost effective method with paraffin wax as a carrier. The release profile of HP was temperature dependent and was tuned to achieve fast or slow release using release rate modifiers.

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