Invited Speaker: Models for Predicting Functional Response to Drug and Vaccine Delivery To and Through SkinĀ 

James C. Birchall

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, CF10 3NB, UK

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Summary
Pre-clinical research commonly exploits animal models to determine drug release into, and permeation through, the skin. Given the significant inter-species differences in skin structure (epidermal and dermal thickness, hair follicle distribution) and skin biology (metabolism, immune function) more predictive laboratory models are required. Excised human skin represents a viable model for relevant physical, biomechanical and biological assessments that can complement animal studies and non-invasive human volunteer studies to better understand the feasibility of new intradermal and transdermal drug delivery approaches.

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