Invited Speaker: Models for Predicting Functional Response to Drug and Vaccine Delivery To and Through SkinĀ 

James C. Birchall

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, CF10 3NB, UK


Pre-clinical research commonly exploits animal models to determine drug release into, and permeation through, the skin. Given the significant inter-species differences in skin structure (epidermal and dermal thickness, hair follicle distribution) and skin biology (metabolism, immune function) more predictive laboratory models are required. Excised human skin represents a viable model for relevant physical, biomechanical and biological assessments that can complement animal studies and non-invasive human volunteer studies to better understand the feasibility of new intradermal and transdermal drug delivery approaches.

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