Biocompatible Dendritic Nanogels for Thermally Triggered Skin Penetration

M. Asadian-Birjand1, F. Rancan2, J. C. Cuggino,1 K. Achazi1, R. C. Mutihac,1 J. Dernedde,1 A. Vogt2, and M. Calderon1*

1 Department of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, 14195, Germany; 2 Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany

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Summary
Herein, we present the development of Rhodamine B labeled thermoresponsive dendritic nanogels (dNGs), which penetrate in human skin upon a thermal trigger. The easiness of the synthetic approach enabled tailoring the nanogels properties, as size and transition temperature. Skin penetration studies highlight their strong potential for pharmaceutical and biomedical application.

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