A New Strategy to Enhance Antibiotic Load for Pulmonary Treatment of Cystic Fibrosis Infections: Ciprofloxacin Lipid Complex Loaded PLGA Nanoparticles

N. Günday Türeli1,3, J. Juntke2, A. Torge3, A. E. Türeli1, EM. Prinz1, C. de Souza Carvalho2, N. Daum2, CM. Lehr2 and M. Schneider3

1MJR PharmJet GmbH, Homburg, 66424, Germany; 2Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, 66123, Germany; 3Pharmaceutics and Biopharmacy, Philipps University Marburg, Marburg, 35032, Germany

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Summary
A novel “counter ion complex” method was developed to overcome the low drug loading efficiencies of antibiotics in biodegradable PLGA nanoparticles. This intriguing approach enhanced drug loading efficiencies by altering solubility characteristics and distinguished itself to serve for development of pulmonary nanoformulations for treatment of cystic fibrosis (CF) infections owing to its higher antibiotic load to deliver to the site of action.

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