Invited Speaker; Spatiotemporal delivery of epigenetic and chemotherapeutic nucleoside analogs to pancreatic cancer

Dr. Rajgopal Govindarajan

Associate Professor, Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA


Recently, it has been shown that a potent chemical inhibitor of S-adenosylhomocysteine hydrolase, 3-deazaneplanocin A (DZNep), modulates chromatin through indirect (i.e., reducing methyl group availability) inhibition of histone methyltransferases including Enhancer of Zeste Homolog 2 (EZH2). DZNep, a carbocyclic analog of adenosine, depletes cellular levels of the Polycomb Repressive Complex 2 (PRC2) components while inhibiting the associated histone H3 at lysine 27 trimethylation (H3K27me3).

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