Injectable, Degradable and Biocompatible Poly(oligoethylene glycol methacrylate) Hydrogels

Emilia Bakaic, Niels M.B. Smeets, and Todd Hoare

Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada

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Summary
A highly tunable, in situ-gelling hydrogel platform based on complementary reactive poly(oligoethylene glycol methacrylate) precursors (POEGMA) has been developed. The physiochemical and biointerfacial properties of these covalently cross-linked POEGMA hydrogels can be systematically varied by changing the composition of the reactive precursors while maintaining high cell viability both in vitro and in vivo. We will demonstrate that these POEGMA hydrogels provide an promising alternative to poly(ethylene glycol) (PEG) for use as biomaterial scaffolds or drug delivery vehicles.

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