In vivo enhancement of transscleral penetration of macromolecules by low-intensity and low-frequency ultrasound 

Wai-leung L. Suen1, Hoi Sang WONG1, Yu YU1, Laurence Chi Ming LAU2, Amy Cheuk-yin LO2, and Ying Chau1

1The Hong Kong University of Science and Technology, Hong Kong SAR, China
2The University of Hong Kong, Hong Kong SAR, China


This study aims to determine in vivo effectiveness of low-frequency ultrasound in mediating the transport of macromolecules to posterior segment of the eye via transscleral route. Investigations were carried out to examine, if any, damage is caused by ultrasound at the tested operation parameters on the posterior ocular tissues and visual function.

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