2016 CRS Annual Meeting Presentations

July 17-20, 2016
Seattle, Washington

The CRS 2016 Annual Meeting presentation webcasts are available to CRS members. Non-member annual meeting attendees have access for one year following the annual meeting for viewing.  

Presentation Categories

Comparative Pharmacokinetics in Preclinical Sciences
Delivery Technologies in Cosmetics, Personal Care, and Household Products
Delivery Technologies in Nutraceuticals, Food, and Oral Products
Encapsulation for Industrial Applications
Industry Roundtable: Clinical Advances in Cancer Nanomedicines
Integration of Imaging and Drug Delivery
Local Drug Delivery
Manufacture, Characterization, Stability, and Regulatory Aspects
Mini Symposia: Developing Therapeutic Options for Combating Cancer: A “One Health” Challenge for Humans and Dogs”
New Processes, New Materials, New Products
Ocular Drug Delivery
Oligonucleotide Delivery: New Applications and Opportunities
Oral Delivery
Overcoming Biological Barriers in Drug Delivery
Parenteral Systemic Delivery of Biopharmaceuticals: Overcoming Product Development and Regulatory Challenges
Peptides, Proteins, and Vaccines
Physical Oncology: Modulating Tumor Microenvironment for Drug Delivery
Preclinical Science Challenges to Drug Delivery
Predictive Modeling in Delivery and Targeting (Scaling: Mouse to Man; Probability of Reaching Targets; Stochastic Process in System Distribution)
Taking Stock of Progress and Challenges in Drug Delivery and Targeting
Thinking Outside the Box Delivery Technologies: Nanocarriers from Nature
Tissue Engineering
Transdermal Delivery

collapse Comparative Pharmacokinetics in Preclinical Sciences

1 Considerations in the Use of the Beagle Dog as a Preclinical Species in Assessing Bioperformance and Oral Sustained Release Technology Development
Presenter: Walsh, Paul. Authors: P. WALSH (1)
(1) Merck & Co., Inc., U.S.A.

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50 Design and Validation of an Intraocular In Vitro Simulator
Presenter: Wang, Joanna. Authors: J. WANG (1), T. Kumeria (1), M. Sailor (1), D. Warther (1)
(1) University of California at San Diego, U.S.A.

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51 Pharmacokinetic-pharmacodynamic analyses of nifedipine and propranolol in rats to investigate characteristics of effect and side effects - applications to controlled release
Presenter: Kiriyama, Akiko. Authors: A. KIRIYAMA (1), S. Kimura (1), N. Shibata (1), K. Iga (1)
(1) Doshisha Women’s College of Liberal Arts, Japan

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52 Biodistribution of GDC-0449 Loaded Micelles in Liver Fibrotic Mice
Presenter: Dutta, Rinku. Authors: R. DUTTA (1), V. Kumar (1), Y. Peng (1), R. Evande (1), J. Grem (1), R. Mahato (1)
(1) University of Nebraska Medical Center, U.S.A.

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53 A phospholipid-based phase separation gel for the prolonged delivery of octreotide
Presenter: Fu, Yao. Authors: M. WANG (1), Z. Zhang (1), T. Gong (1), Y. Fu (1)
(1) Sichuan University, China

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54 Development of in-vivo Method for Intranasal Delivery of Powder or Solution Formulation
Presenter: Bhyrapuneni, Gopinadh. Authors: J. RAVULA (1), S. Irappanavar (1), N. Muddana (1), G. Bhyrapuneni (1), D. Dogiparti (1), D. Sisodaya (1), N. Patibandla (1), R. Eeda (1), B. Devarapalli (1), R. Nirogi (1)
(1) Suven Life Sciences Limited, India

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55 In Vitro / In Vivo Extrapolation (IVIVE) of API Dissolution within a PBPK Framework
Presenter: Liu, Bo. Authors: B. LIU (1), D. Turner (1)
(1) Simcyp, United Kingdom

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56 Bioavailability and pharmacokinetics of zidovudine mucoadhesive polymeric nanoparticles in rats
Presenter: Pedreiro, Liliane. Authors: L. PEDREIRO (1), B. S. Ferreira Cury (1), V. Merino (2), A. Catalán (2), M. Merino (2), M. Gremião (1)
(1) School of Pharmaceutical Sciences, São Paulo State Universit “Júlio de Mesquita Filho”, Brazil; (2) Center for Molecular Recognition and Technological Development, Universit of Valencia, Spain

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57 Wet-milled nanoparticulate suspensions (Wnano) of compound A formulated in subcutaneous pumps for in vivo sustained release in preclinical studies
Presenter: Zhang, Tao. Authors: T. ZHANG (1)
(1) Pfizer Inc, U.S.A.

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58 Biodistribution and pharmacokinetics of celastrol in rats after intravenous administration
Presenter: Guo, Ling. Authors: L. GUO (1), S. Luo (1), Z. Zhang (1)
(1) Sichuan University, China

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collapse Delivery Technologies in Cosmetics, Personal Care, and Household Products

2 Bijel capsules – a novel architecture for simultaneous delivery of hydrophilic and hydrophobic materials
Presenter: Thijssen, Job. Authors: J. THIJSSEN (1), J. Tavacoli (1), A. Schofield (1), P. Clegg (1)
(1) The University of Edinburgh, United Kingdom

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59 Coffee silverskin and hyaluronic acid as anti-wrinkles ingredients: An in vivo comparison study
Presenter: Rodrigues, Francisca. Authors: R. Matias (1), M. Ferreira (1), M. Amaral (2), M. Oliveira (3), F. Rodrigues (1)
(1) Inovapotek, Pharmaceutical Research & Development, Porto, Portugal, Portugal; (2) Faculty of Pharmacy, University of Porto, Porto, Portugal, Portugal; (3) Requimte, Faculty of Pharmacy, University of Oporto, Portugal

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60 Engineering Chitosan-Calcium Tripolyphosphate Composite Microparticles: From Core/Shell to Coated Matrix and Coated Reservoir Microencapsulation System
Presenter: Tchuenbou-Magaia, Fideline. Authors: F. TCHUENBOU-MAGAIA (1), C. Glasse (2), B. Gottenbos (3), Q. Williams (4), N. Young (5), Z. Zhang (1)
(1) University of Birmingham, United Kingdom; (2) Philips Oral healthcare, United Kingdom; (3) Philips Group Innovation/Research, Netherlands; (4) Philips Oral Healthcare, Netherlands; (5) Philips, United Kingdom

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61 Rheological Characterization and In Vitro Permeation of Menthol Gels for Topical Application
Presenter: Manian, Mahima. Authors: M. MANIAN (1)
(1) Mercer University, U.S.A.

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62 Synergistic Effects of Metformin Treatment in Combination with Magnolol Nano- and Micro- Particles in Human Oral Cancer Cells
Presenter: Shih, Pin-Yi. Authors: C. KAO (1)
(1) National Taiwan University of Science and Technology, Taiwan

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63 Evaluation of in vitro evaporation profile of a natural insect repellent (citronella oil) impregnate in mesoporous silica
Presenter: Mendoza Munoz , Nestor. Authors: N. MENDOZA MUÑOZ (1), B. JAIME ESCALANTE (2), J. GONZALEZ GONZALEZ (1)
(1) UNIVERSIDAD DE COLIMA, Mexico; (2) UNIVERSIDAD AUTONOMA DE NAYARIT, Mexico

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64 Amine-modification of Silica Nanoparticles Reduces Lung Inflammation in Mice
Presenter: Morris, Angie. Authors: A. MORRIS (1), A. Adamcakova-Dodd (1), S. Lehman (1), A. Wongrakpanich (1), P. Thorne (1), S. Larsen (1), A. Salem (1)
(1) University of Iowa, U.S.A.

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65 The Effect of Aldehydes on Polyurea Encapsulated Fragrance for Consumer Products
Presenter: Evans-Lora, Timothy. Authors: T. EVANS-LORA (1), P. Ott (2), K. Behrens (2)
(1) Symrise Inc., U.S.A.; (2) Symrise Inc., Germany

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collapse Delivery Technologies in Nutraceuticals, Food, and Oral Products

3 Stabilization of water-in-water emulsions
Presenter: Tromp, Robert. Authors: R. TROMP (1)
(1) NIZO food research, Netherlands

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66 Enteric Coating of Micronized API Particles using a Wurster Fluid-Bed Process
Presenter: Leung, Cheuk-Yui. Authors: C. LEUNG (1), A. Trementozzi (1), P. Zawaneh (1), Y. Lin (1), E. Irdam (1), S. Karki (1)
(1) Biogen, U.S.A.

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67 A Soluplus®-dispersed Sustained-release Tablet for Imperialine to Simultaneously Prolong the Drug Release and Improve the Oral Bioavailability
Presenter: Lin, Qing. Authors: Q. LIN (1), Y. Fu (1), J. Li (1), M. Qu (1), L. Deng (1), T. Gong (1), Z. Zhang (1)
(1) West China School of Pharmacy, Sichuan University, China

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68 Food Grade Gelatin/Gum Arabic Capsules for In-Dough Extruded Snack/Cereal Applications Anticancer Drug for Colon Targeting
Presenter: Wieland, Julie. Authors: J. WIELAND (1), L. Henson (1), M. Popplewell (1)
(1) International Flavors & Fragrances, U.S.A.

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69 A Simple and Improved Active Loading Method to Efficiently Encapsulate Staurosporine into Lipid-Based Nanoparticles for Enhanced Therapy of Multidrug Resistant Cancer
Presenter: Tang, Wei-Lun. Authors: W. TANG (1)
(1) University of British Columbia, Canada

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70 Microencapsulated Diindolylmethane (DIM): Optimizing Formulation Performance and Market Appeal
Presenter: Jacobs, Irwin. Authors: I. JACOBS (1), M. Zeligs (2)
(1) Jacobs Controlled Release Consulting, LLC, U.S.A.; (2) BioResponse Nutrients, LLC, U.S.A.

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71 Particulate Based Formulation Approaches for Colonic Delivery of Prednisone
Presenter: Gupta, Pranav. Authors: P. GUPTA (1), A. Rumondor (1), S. Forster (1), K. Hogan (1), D. Carroll (1), B. Xia (1), F. Kesisoglou (1)
(1) Merck and Co.,, U.S.A.

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72 Effect of Formulation and Process Variables on Drug Release from Coated Pellets for Colonic Delivery of Prednisone
Presenter: Gupta, Pranav. Authors: P. GUPTA (1), J. Xu (1), C. Spencer (1), D. Carroll (1)
(1) Merck and Co.,, U.S.A.

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73 Oxidative Stability Prediction of Microencapsulated Flavor Using an Accelerated Oxidation Test and True Particle Density
Presenter: van Sleeuwen , Rutger. Authors: J. ZHANG (1), R. van Sleeuwen (1), B. MacDougall (1), A. Schober (1)
(1) Firmenich, Inc., U.S.A.

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75 Taste Masking Strategies Using Ion Exchange Excipients
Presenter: Gehris, Amie. Authors: A. GEHRIS (1), A. Faham (1), P. Garcia Todd (1), S. Iuliano (1)
(1) The Dow Chemical Company, U.S.A.

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76 Development Optimization and Characterization of Paclitaxel loaded Nanostructured Lipid Carriers using Box Behnken design
Presenter: Mittal, Pooja. Authors: P. MITTAL (1)
(1) Department of Pharmaceutics, IIT (BHU), Varanasi, India

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77 The Phytochemical Chlorogenic Acid Rescues Oxidative Damage in a Zebrafish Model
Presenter: McDowell, Arlene. Authors: A. MCDOWELL (1), I. Hold (2), J. Chiu (1), T. Newman (1), J. Horsfield (1)
(1) University of Otago, New Zealand; (2) University of Graz, Austria

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78 Phytosomes - a Nanoformulation to Improve the Solubility of Rutin
Presenter: McDowell, Arlene. Authors: A. MCDOWELL (1), H. Vu (1), S. Hook (1)
(1) University of Otago, New Zealand

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81 Development of Novel Curcumin Formulation (NCF) for Cancer and Alzheimer Disease (AD)
Presenter: Parikh, Ankit. Authors: A. PARIKH (1), K. Kathawala (1), Y. Song (1), C. Tan (1), Z. Shan (1), X. Zhou (1), S. Garg (1)
(1) University of South Australia, Australia

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82 Drug Release Profile of Nanoparticle-Hydrogel Formulations for Sustained Delivery of Tacrolimus
Presenter: Nguyen, Duc. Authors: D. NGUYEN (1), R. Kinser (2), B. Doddapaneni (2), A. Alani (2)
(1) Oregon State University College of Pharmacy, U.S.A.; (2) Oregon state university, U.S.A.

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83 A Novel In Vitro Tool for Formulation Optimization and Streamline the Selection of Suitable Candidate Formulations for Bioavailability and Bioequivalence Studies in Humans
Presenter: Li, Jibin. Authors: J. LI (1), N. Nessah (1), Y. Huang (1), S. Silchenko (1)
(1) Absorption Systems, U.S.A.

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84 Microfluidics-based manufacture of protein-loaded liposomes.
Presenter: Hussain, Maryam. Authors: M. HUSSAIN (1)
(1) Aston University, United Kingdom

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collapse Encapsulation and Controlled Release for Industrial Applications

85 Hyaluronic acid ion pairing nanoparticles for targeted tumor therapy
Presenter: Li, Wenhao. Authors: W. LI (1)
(1) West China School of Pharmacy, Sichuan University, China

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86 Colloidal Mesoporous Silica Nanoparticles with Large-pore Sizes for Encapsulation of Various Proteins
Presenter: Tu, Jing. Authors: J. TU (1), A. Kros (1), P. Bomans (2), N. Sommerdijk (2), W. Jiskoot (1)
(1) Leiden University, Netherlands; (2) Eindhoven University of Technology, Netherlands

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87 Controlled release of microencapsulated active from coatings: Polyelectrolyte shells as globally rate-determining barriers
Presenter: Bergek, Jonatan. Authors: J. BERGEK (1), M. Andersson Trojer (2), L. Nordstierna (1)
(1) Chalmers University of Technology, Sweden; (2) Swerea IVF, Sweden

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88 Targeting NF-kB pathway by co-delivery of siRNA and dexamethasone using a polymeric hybrid micelles for arthritis therapy
Presenter: Wang, Qin. Authors: Q. WANG (1)
(1) Sichuan University, China

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89 Flame Retardant Encapsulation for Preparation of Nanofoams
Presenter: Chen, Liang. Authors: L. CHEN (1), A. Kelly-Rowley (1), S. Bunker (1), S. Costeux (1)
(1) The Dow Chemical Company, U.S.A.

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90 Development of controlled release Fingolimod by means of an injectable PHBV nanoparticles-Grafted alginate hybrid system
Presenter: Dorkoosh, Farid. Authors: F. DORKOOSH (1), L. Rezaie Shirmard (2)
(1) Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Ira, Iran; (2) Ardebil University of medical science, Ardebil, Iran, Iran

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91 Interfacial Microencapsulation Fundamentals: Re-visiting Select Historical Patents
Presenter: Essinger, James. Authors: J. ESSINGER (1)
(1) Gowan Company, U.S.A.

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92 Development of injectable nanoparticles using photo-curable natural polymer derivatives for osseointegration of implant
Presenter: Son, Tae Il. Authors: T. SON (1), G. HAN (1), E. KIM (1), J. JEONG (1)
(1) CHUNG-ANG UNIVERSITY, South Korea

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93 Controlled release of pheromone from ester waxes for prevention of Grapholita Molesta (GM)
Presenter: Yoon, Ji Young. Authors: J. YOON (1), D. Kim (1), J. Kim (1)
(1) Korea Advanced Institute of Science and Technology, South Korea

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94 One-Pot Preparation of Detergent-Resistant Polymersomes through RAFT Dispersion Polymerization
Presenter: Song, Ziyuan. Authors: Z. SONG (1), Y. Huang (1), V. Prasad (2), R. Baumgartner (1), S. Zhang (1), J. Cheng (1)
(1) University of Illinois at Urbana-Champaign, U.S.A.; (2) The Dow Chemical Company, U.S.A.

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95 Chain-Shattering Polymer Strategy for Herbicide Encapsulation and UV-Triggered Release
Presenter: Cai, Kaimin. Authors: K. CAI (1), Y. Zhang (1), J. Cheng (1)
(1) University of Illinois at Urbana-Champaign, U.S.A.

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96 Novel contrast agents for Targeted Biomedical Imaging
Presenter: Vandamme, Thierry. Authors: N. ANTON (1), M. Attia (1), T. Vandamme (1)
(1) University of Strasbourg, France

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97 Parylene Coated Chemicals for Downhole Treatments
Presenter: Versic, Ronald J. Authors: R. VERSIC (1)
(1) Ronald T. Dodge Company, U.S.A.

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98 Prediction of Dissolution-Diffusion Controlled Drug Release from Coated Multi-particulate Dosage Forms with Consideration of Interfacial Drug Partition between Layers
Presenter: Wu, Xiao Yu. Authors: X. WU (1), Y. zhou (2), X. Guo (3), K. Chen (1)
(1) University of Toronto, Canada; (2) AP-CAD Inc., Canada; (3) Prinston Pharma, U.S.A.

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99 Development of a reverse phase Waters HPLC method and solid state engineering and characterisation of co-enzyme Q10 using supercritical carbon dioxide
Presenter: Wen, Jingyuan. Authors: J. WEN (1), Y. Zhou (1), G. Chen (1), S. Chen (1)
(1) School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand

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100 Nanostructured liquid crystalline nanoparticles as agricultural chemical adjuvant systems
Presenter: Bisset, Nicole. Authors: N. BISSET (1), B. Boyd (1), Y. Dong (1), G. Webster (1)
(1) Monash Institute of Pharmaceutical Sciences, Australia

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101 Injectable Hydrogel from Synthetic Cyclic Vinyl Polymers for Cell Therapy
Presenter: Zhao, Tianyu. Authors: T. ZHAO (1)
(1) University of Washington, U.S.A.

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102 INFLUENCE OF EXTENT OF CROSS-LINKING ON THE PHYSICAL PROPERTIES OF SPRAY-DRIED ALGINATE MICROCAPSULES
Presenter: Scher, Herbert. Authors: H. SCHER (1), S. Strobel (1), N. Nitin (2), T. Jeoh (1)
(1) UC Davis, Biological and Agricultural Engineering, U.S.A.; (2) UC Davis, Biological and Agricultural Engineering and Food Science and Technology, U.S.A.

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103 Reversible Thermoresponsive Capsules from N-Vinylcaprolactam systems and Their Studies
Presenter: Ranganathan, Krishnan. Authors: K. RANGANATHAN (1)
(1) Institute of Chemical and Engineering Sciences, Singapore

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104 Preparation and Evaluation of Biodegradable poly(D,L-lactide-co-glycolide) Microsphere for Sustained Release of Tamsulosin
Presenter: Kim, Bong-Oh. Authors: B. KIM (1), H. Jang (1), M. Yun (1), S. Jeong (1), Y. Yi (1)
(1) Samyang Biopharmaceuticals Corporation, Korea

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collapse Industry Roundtable: Clinical Advances in Cancer Nanomedicines

33 VYXEOS™ (CPX-351) significantly improves overall survival in phase 3 high-risk AML trial, validating the CombiPlex technology and opening opportunities for novel combinations
Presenter: Mayer, Lawrence. Authors: L. MAYER (1), B. Liboiron (1), S. Xie (1), P. Tardi (1), K. Paulson (2), M. Chiarella (2), A. Louie (2)
(1) Celator Pharmaceuticals Corp., Canada; (2) Celator Pharmaceuticals, Inc., U.S.A.

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collapse Integration of Imaging and Drug Delivery

5 Current and future opportunities for image-guided nanotherapy
Presenter: Ferrara, Katherine. Authors: K. FERRARA (1)
(1) UC Davis, U.S.A.

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106 Development of Next Generation Magnetic Lipid Nanoparticles for Theranostics
Presenter: Biswas, Souvik. Authors: S. BISWAS (1), J. Kulkarni (1), C. Tam (1), P. Cullis (1)
(1) Life Sciences Institute, University of British Columbia, Canada

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107 Graphene Oxide-Incorporated pH-Responsive Folate-Albumin-Photosensitizer Nanocomplex as Image-Guided Dual Therapeutics
Presenter: Battogtokh, Gantumur. Authors: G. BATTOGTOKH (1), Y. Ko (2), O. Gotov (2), J. Kang (2)
(1) College of Pharmacy, Gachon University, Korea; (2) College of Pharmacy, Gachon University, South Korea

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108 Ultrasound responsive proapoptotic-liposome-bubble conjugates as a platform for image-guided cancer therapeutics
Presenter: Chandan, Rajeet. Authors: R. CHANDAN (1), R. Banerjee (1)
(1) Indian Institute of Technology Bombay, India

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109 Temperature-responsive fluorescence polymer nanoparticles with thermally controlled cellular uptakes
Presenter: Hiruta, Yuki. Authors: Y. HIRUTA (1), R. Nemoto (1), Y. Nagata (1), H. Kanazawa (1)
(1) Keio University, Japan

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110 A Nanomedicine Biodegradable Platform for Image-Guided Surgery and Intraoperative Phototherapy for Ovarian Cancer Treatment
Presenter: Taratula, Oleh. Authors: O. TARATULA (1), O. Taratula (1), B. Doddapaneni (1), C. Schumann (1), X. Li (1), A. Alani (1)
(1) Oregon State University, U.S.A.

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111 Mesoporous Carbon Nanoparticles as Carriers of Neutron-Activatable Therapeutic Radionuclides
Presenter: Kim, Junghyun. Authors: J. KIM (1), K. Kim (1), M. Jay (1)
(1) University of North Carolina at Chapel Hill, U.S.A.

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112 Biodegradable CMS Nanotransporter for Topical Dexamethasone Delivery
Presenter: Hedtrich, Sarah. Authors: S. HEDTRICH (1), S. Hönzke (1), A. Elpelt (1), M. Unbehauen (1), E. Fleige (2), F. Paulus (2)
(1) FU Berlin, Germany; (2) Dendropharm, Germany

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113 Cancer environment responsive nanoparticle contrast agent for MR Imaging
Presenter: Jung, Yeonjin. Authors: Y. JUNG (1)
(1) The catholic university of Korea, Korea

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114 PLGA nanoparticle decorated with iron oxide nanoprecipitates for EPR independent drug delivery
Presenter: Park, Jinho. Authors: J. PARK (1), N. Kadasala (2), S. Abouelmagd (2), M. Castanares (1), D. Collins (1), A. Wei (2), Y. Yeo (2)
(1) Eli Lilly and Company, U.S.A.; (2) Purdue university, U.S.A.

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115 A Tumor-Activated Switch-ON NIR Nanoprobe for Image-Guided Phototherapy
Presenter: Li, Xiaoning. Authors: X. LI (1), O. Taratula (2), O. Taratula (2)
(1) 1Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, U.S.A.; (2) Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, U.S.A.

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116 Tumor-targeted Theranosis based on Polyglycerolated Lipiodol Nanoemulsions
Presenter: Kim, Jee Seon. Authors: J. KIM (1), T. Le Kim (1), J. Kim (2), K. Park (2), J. Kim (3), Y. Nam (1)
(1) KAIST, South Korea; (2) Samsung Medical Center, South Korea; (3) Hanyang University, South Korea

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117 Rapid High Resolution Multi-Parameter Characterization of Liposome-Protein Complexes by Nanoparticle Tracking Analysis
Presenter: Ragheb, Ragy. Authors: R. RAGHEB (1), E. Esposito (1), C. Deighan (1), D. Griffith (1)
(1) Malvern Instruments, U.S.A.

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118 In-vitro and In-vivo Uptake of Liposomal Quantum Dots by Phagocytic Cells: Effective Approach for Imaging of Inflammation
Presenter: Golomb, Gershon. Authors: G. GOLOMB (1), G. Aizik (1), N. Waiskopf (1), M. Agbaria (1), U. Banin (1)
(1) The Hebrew University of Jerusalem, Israel

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119 In situ targeted activation of a glucuronide prodrug using ultrasound-triggered release of composite droplets
Presenter: Bezagu, Marine. Authors: M. BEZAGU (1), J. CLARHAUT (2), F. MONTI (3), P. TABELING (3), J. COSSY (4), S. PAPOT (5), M. TANTER (1), O. COUTURE (1), S. ARSENIYADIS (4)
(1) Institut Langevin (CNRS, ESPCI, INSERM), France; (2) IC2MP (Université de Poitiers, CNRS), CHU Poitiers, France; (3) MMN (ESPCI, CNRS, UPMC), France; (4) LCO (ESPCI, CNRS, UPMC), France; (5) IC2MP (Université de Poitiers, CNRS), France

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120 Doxorubicin-loaded MnCO3 Nanoparticles as a Theranostic Agent
Presenter: Kim, Ki Duk. Authors: K. KIM (1), J. Lee (1), J. Hong (1), S. Jeong (1), S. Lee (1)
(1) Kyung Hee University, Korea

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121 Self-Assembled Dextran Sulfate Nanoparticles for Targeted Therapy of Rheumatoid Arthritis
Presenter: Heo, Roun. Authors: R. HEO (1), D. You (1), R. Vijayakameswara (1), J. Park (1)
(1) Sungkyunkwan University, Korea

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122 Mapping of Antiangiogenic Drug Distribution in a Rabbit Model of Liver Cancer by Fluorescence Microscopy and MALDI-SRM/MS Imaging
Presenter: Fuchs, Katrin. Authors: K. FUCHS (1), A. Kiss (2), P. Bize (3), R. Duran (3), A. Denys (3), G. Hopfgartner (2), G. Borchard (1), O. Jordan (1)
(1) University of Geneva - School of Pharmacy, Switzerland; (2) University of Geneva, Switzerland; (3) CHUV Centre Hospitalier Universitaire Vaudois, Switzerland

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123 Development of a metal tungstate-based nanoparticle platform for CT-guided chemotherapy
Presenter: Lee, Jaewon. Authors: J. LEE (1), S. Choi (1), H. Heng (1), S. Torregrosa-Allen (1), B. Ramsey (1), B. Elzey (1), Y. Won (1)
(1) Purdue University, U.S.A.

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124 Augmenting drug-carrier compatibility improves tumor nanotherapy efficacy
Presenter: Zhao, Yiming. Authors: Y. ZHAO (1), F. Fay (1), S. Hak (2), B. Sanchez-Gaytan (1), C. Pérez-Medina (1), W. Mulder (1)
(1) Icahn School of Medicine at Mount Sinai, U.S.A.; (2) Norwegian University of Science and Technology, Norway

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125 Dual-Targeting Immunoliposomes Conjugated with Anti-CD133 mAb and Angiopep-2 for GSCs
Presenter: Kim, Jung Seok. Authors: J. KIM (1), S. Oh (1), G. Lee (1), J. Kim (1)
(1) Research Center for Cell Fate Control (RCCFC) & College of Pharmacy, Sookmyung Women's University, South Korea

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126 Aptamosomes as Dual-Drug Delivery System for The Treatment of MCF-7 Breast Cancer Cells and Breast Cancer Stem Cells
Presenter: Kim, Keun-sik. Authors: K. KIM (1)
(1) KONYANG UNIVERSITY, South Korea

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127 Biocompatible Albumin/SPIO Nanocomplexes for Cancer Theranostic Applications
Presenter: SsuYu, Lin. Authors: L. SSUYU (1)
(1) National Tsing Hua University, Taiwan

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128 A Bottom-up Approach for the Synthesis of Self-assembled Nanostructures with Theranostic Capabilities
Presenter: Sanchez-Gaytan, Brenda. Authors: B. SANCHEZ-GAYTAN (1), Y. Zhao (1), F. Fay (1), Z. Fayad (1), W. Mulder (1)
(1) Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, U.S.A.

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129 Monitoring disposition of lipid-based formulations for sustained release using X-ray CT imaging
Presenter: Boyd, Ben. Authors: B. BOYD (1), L. Hong (2), A. Pham (2), T. Nguyen (2)
(1) Monash University, Australia; (2) Monash Institute of Pharmaceutical Sciences, Australia

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130 Real-Time Volumetric Imaging of Nanoparticle Transport in the Rat Cortex
Presenter: Rosch, Justin. Authors: J. ROSCH (1), P. Gadamsetty (1), C. Schaffer (1), W. Olbricht (1)
(1) Cornell University, U.S.A.

View Abstract | View Presentation

131 Effect of Phospholipase A2 Receptor (PLA2R) Expression on Tumorgenesis and Performance of Lipid-Nanomedicines in Prostate Cancer
Presenter: Arnold, Robert. Authors: R. ARNOLD (1), M. Eggert (1), B. Nie (1), A. Brannen (1), N. Quach (2), P. Panizzi (1), B. Cummings (2)
(1) Auburn University, U.S.A.; (2) University of Georgia, U.S.A.

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132 Investigating tumor cell specificity of a nanoparticle with a surface-converting coating by multimodal imaging
Presenter: Fay, Francois. Authors: F. FAY (1), L. Hansen (2), Z. Fayad (3), C. Perez-medina (3), W. Mulder (3)
(1) Translational and Molecular Imaging Institute, Icahn School Icahn School of Medicine at Mount Sinai, U.S.A.; (2) Interdisciplinary Nanoscience Center, Aarhus University, Denmark; (3) Translational and Molecular Imaging Institute, Icahn School of Medic

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133 Muco-adhesive Polycaprolactone Microparticles as Carriers for Nasal Delivery of Vaccines
Presenter: Gorantla, Yamini. Authors: Y. GORANTLA (1), M. Yeboah (1), R. Palaniappan (1)
(1) Mercer University, U.S.A.

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134 Using ultrasound to enhance tumor cell killing by doxorubicin-loaded particles
Presenter: Do, Anh-Vu. Authors: A. DO (1), K. Jang (1), D. Seol (1), A. Salem (1), J. Martin (1)
(1) The University of Iowa, U.S.A.

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135 Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release
Presenter: Kong, Seong. Authors: S. KONG (1), L. Zhang (2)
(1) California Baptist University, U.S.A.; (2) University of Califronia, San Diego, U.S.A.

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136 Fact of PEG-related antibody generation and its relation to accelerated blood clearance
Presenter: Shiraishi, Kouichi. Authors: K. SHIRAISHI (1), K. Kawano (2), Y. Maitani (2), M. Yokoyama (1)
(1) The Jikei University School of Medicine, Japan; (2) Hoshi University, Japan

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137 Ultrasound monitoring of a subcutaneous liquid crystal drug delivery system
Presenter: Otte, Andrew. Authors: A. OTTE (1), Y. Baez (1), C. Berlant (1), Y. Lee (1), B. Soh (1), C. Song (1), C. Goergen (1), K. Park (1)
(1) Purdue University, U.S.A.

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138 Imaging guided Therapeutic Modulation of Hepatocellular Carcinoma using Two Complementary MicroRNAs
Presenter: Mullick Chowdhury, Sayan. Authors: S. MULLICK CHOWDHURY (1), T. Wang (1), S. Bachawal (1), R. Devulapally (1), R. Paulmurugan (1), J. Willamann (1)
(1) Stanford University, U.S.A.

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139 Biodistribution of insulin-loaded biopolymer-based submicron particles
Presenter: Ribeiro, Antonio. Authors: A. RIBEIRO (1), A. Denise (1), M. Lopes (1)
(1) Faculty of Pharmacy, University of Coimbra, Portugal

View Abstract

140 Pharmacokinetic Properties of Rotigotine Extended-Release Microspheres for Injection in Healthy and Patient Caucasian Volunteers
Presenter: Yu, Fei. Authors: Y. LI (1), C. Sha (1)
(1) LUYE Pharma Group Ltd, China

View Abstract

141 Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via ?-? Stacking Stabilized Polymeric Micelles
Presenter: van der Meel, Roy. Authors: R. VAN DER MEEL (1), Y. Shi (2), B. Theek (3), E. Oude Blenke (4), E. Pieters (4), M. Fens (5), J. Ehling (3), R. Schiffelers (5), G. Storm (4), C. van Nostrum (4), T. Lammers (3), W. Hennink (4)
(1) University of British Columbia / University Medical Center Utrecht, Canada; (2) South China University of Technology, China; (3) RWTH Aachen University, Germany; (4) Utrecht University, Netherlands; (5) University Medical Center Utrecht, Netherlands

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142 Cytosolic delivery of nanomaterials into living cells by vapour nanobubble photoporation
Presenter: De Smedt, Stefaan. Authors: S. DE SMEDT (1)
(1) Laboratory of General Biochemistry and Physical Pharmacy, Belgium

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143 Combination of a fluorescent dye with DPI formulations to improve in vivo imaging
Presenter: Bagnacani, Valentina. Authors: V. BAGNACANI (1)
(1) Chiesi Farmaceutici, Italy

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144 Design of experiments for optimisation of droplet size and non-invasive imaging techniques to study its effect on film coat quality
Presenter: Dennison, Tom. Authors: T. DENNISON (1)
(1) Aston University, United Kingdom

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145 Development of a Freeze-dried Lipid-stabilized Nanobubble for Ultrasound Imaging and Gene Delivery
Presenter: Unga, Johan. Authors: J. UNGA (1), D. Omata (1), Y. Oda (1), M. Sugii (1), H. Uruga (1), R. Suzuki (1), K. Maruyama (1)
(1) Teikyo University, Japan

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146 Utilizing Ultrasound and Infrared to Image Intradermal Drug Delivery using a Hollow Microstructured Transdermal System
Presenter: Hua, Vinh. Authors: A. BOHLKE (1), S. Burton (1), C. Ng (1)
(1) 3M Drug Delivery Systems Division, U.S.A.

View Abstract
collapse Local Drug Delivery

6 Local image-guided drug delivery across the Blood-Brain barrier (BBB) using focused ultrasound
Presenter: Hynynen, Kullervo. Authors: K. HYNYNEN (1)
(1) University of Toronto, Canada

View Abstract

147 In vitro and in vivo behaviors of DNA tetrahedrons as tumor-targeting nanocarriers for doxorubicin
Presenter: Kang, Ji Hee. Authors: J. KANG (1), Y. Ko (1), W. Jang (1)
(1) College of Pharmacy/Gachon University, Korea

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148 Pharmacokinetics and preventive effects of platinum nanoparticles as reactive oxygen species scavengers on peritoneal dissemination of tumor cells
Presenter: Katsumi, Hidemasa. Authors: H. KATSUMI (1), T. Mizuyama (1), S. Maruyama (1), N. Kitamura (1), K. Kusamori (1), T. Sakane (1), A. Yamamoto (1)
(1) Kyoto Pharmaceutical University, Japan

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149 Synthesis of the novel both terminal-acryloyl polymers for the development of biomolecule-responsive drug carriers
Presenter: Murakami, Yoshiko. Authors: Y. MURAKAMI (1), K. Kinoshita (1), T. Takami (1)
(1) Tokyo University of Agriculture and Technology, Japan

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150 Development of novel porous PEG-PLA/PLGA microparticles via "one-step" emulsification for pulmonary drug delivery
Presenter: Takami, Taku. Authors: Y. MURAKAMI (1), T. Takami (1)
(1) Tokyo University of Agriculture and Technology, Japan

View Abstract

151 Trilayered polymeric micelles, newly-developed macromolecular assemblies, for a sustained release of hydrophilic compounds
Presenter: Fukuda, Kengo. Authors: Y. MURAKAMI (1), K. Fukuda (1), T. Takami (1)
(1) Tokyo University of Agriculture and Technology, Japan

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152 Nanocrystal-Polymer Particles: a Novel Approach to Treat Osteoarthritis
Presenter: Maudens, Pierre. Authors: P. MAUDENS (1), L. Neff (1), C. Thauvin (1), O. Jordan (1), E. Allémann (1)
(1) University of Geneva, Switzerland

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153 Combination chemotherapy of doxorubicin and paclitaxel against human liver cancer cells by self-solidifying polymeric drug delivery system
Presenter: Nasongkla, Norased. Authors: N. NASONGKLA (1), N. Suwannakul (2), P. Nittayacharn (2)
(1) Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Thailand; (2) Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Thailand

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154 Cleavable Gold Nanoclusters for High Drug Payload and Efficient Tumor Targeting
Presenter: Yoo, Hyuksang. Authors: W. MAO (1)
(1) Department of Medical Biomaterials Engineering, Kangwon National University, South Korea

View Abstract

155 Vaginal Delivery of Hydroxychloroquine via a Trackable Polyurethane Implant Protects against Nonoxynol-9 Induced Inflammation
Presenter: Chen, Yufei. Authors: Y. CHEN (1), Y. Traore (1), S. Yang (1), A. Stalker (1), J. Lajoie (1), K. Fowke (1), D. Rickey (1), E. Ho (1), Y. Chen (1)
(1) University of Manitoba, Canada

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156 Development and Characterization of Bendamustrine-Dendrimer Conjugates for the Improved Stability and Efficacy
Presenter: Gothwal, Avinash. Authors: A. GOTHWAL (1), U. Gupta (2)
(1) Department of Pharmacy, Central University of Rajasthan, India; (2) Central University of Rajasthan, India

View Abstract

157 Rheological Characterization of Human Peritoneal Fluid following Abdominal Surgery
Presenter: Svirskis, Darren. Authors: D. SVIRSKIS (1), P. Bhusal (1), J. Rahiri (1), M. Sharma (1), J. Harrison (1), G. Procter (2), G. Andrews (3), D. Jones (3), A. Hill (1)
(1) University of Auckland, New Zealand; (2) Queen's University Belfast, New Zealand; (3) Queen's University Belfast, Northern Ireland

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158 Targeted co-delivery of dual-function monoclonal antibody and tipranavir to gut-homing T cells using lipid-coated PLGA nanoparticles
Presenter: Cao, Shijie. Authors: S. CAO (1), Y. Jiang (1), N. Kondza (1), K. Woodrow (1)
(1) University of Washington, U.S.A.

View Abstract

159 HA-based nanocomplexes for targeting drug delivery to lymphatic metastatic tumors
Presenter: Liu, Chih-Peng. Authors: C. LIU (1)
(1) Industrial Technology Research Institute, Taiwan

View Abstract

160 Drug eluting stent for efficient penetration of hydrophilic drug into cancer
Presenter: Seo, Jeongdeok. Authors: J. SEO (1)
(1) The Catholic University of Korea, South Korea

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161 Investigation of novel biomaterials based nanoformulations of anti-TNF monoclonal antibody to treat inflammation in an in-vitro cell culture model
Presenter: Bakhaidar, Rana. Authors: R. PABARI (1)
(1) Royal College of Surgeons in Ireland, Ireland

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162 Local delivery of atorvastatin with enhanced solubility for the treatment of periodontal disease
Presenter: Senel, Sevda. Authors: S. SENEL (1), A. OZDOGAN (2), G. AKCA (3)
(1) Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Turkey; (2) Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology , Turkey; (3) Gazi University, Faculty of Dentistry, Department of Medic

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164 Drug release from biodegradable polymer grafted bioprosthetic tissue
Presenter: Pal, Amrita. Authors: B. VERNON (1), A. Pal (1), C. Pathak (1)
(1) Arizona State University, U.S.A.

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165 Nanoparticles-in-Vaginal Film for Combined Delivery of Anti-HIV Microbicide Drugs
Presenter: Sarmento, Bruno. Authors: J. DAS NEVES (1), C. Cunha-Reis (2), A. Machado (1), F. Araújo (1), R. Nunes (1), B. Sarmento (1)
(1) i3S, University of Porto, Portugal; (2) CESPU, Portugal

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166 Light-Triggered Tumor Targeted Delivery of Anticancer Therapeutics Using ROS-sensitive Polymeric Micelles
Presenter: Seah, Geok Leng. Authors: G. SEAH (1), J. Kim (1), J. Yu (1), Y. Nam (1)
(1) Korea Advanced Institute of Science and Technology (KAIST), South Korea

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167 pH-sensitive RNAi-based combination nanomicrobicide for the induction of autophagy as a strategy for preventing vaginal transmission of HIV
Presenter: Yang, Sidi. Authors: S. YANG (1), J. Gu (1), Y. Chen (1), M. Fumakia (1), E. Ho (1)
(1) University of Manitoba, Canada

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168 Investigating the physical stability of a spray-dried pulmonary drug delivery system
Presenter: Chia, Leonard. Authors: L. CHIA (1), A. Zeitler (1), W. Ng (2), R. Tan (2), G. Moggridge (1)
(1) University of Cambridge, United Kingdom; (2) Institute of Chemical and Engineering Sciences, A*STAR, Singapore

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169 Boronic acid-functionalized polycarbonate hydrogels for Polymyxin B delivery towards wound healing
Presenter: Obuobi, Sybil. Authors: S. OBUOBI (1), Z. Voo (2), R. Ee Pui Lai (1), Y. Yang (2)
(1) National University of Singapore, Singapore; (2) Institute of Bioengineering and Nanotechnology, Singapore

View Abstract

170 A systematic development of liposomes to enhance lymphatic drug targeting
Presenter: Khadke, Swapnil. Authors: S. KHADKE (1), Y. Perrie (1), A. Cameron (1), A. Devitt (1)
(1) Aston University, United Kingdom

View Abstract | View Presentation

171 In vitro and in vivo characterization of gemcitabine loaded Phosphatidyldiglycerol-based thermosensitive liposomes
Presenter: Kneidl, Barbara. Authors: B. KNEIDL (1), M. Hossann (1), S. Limmer (1), L. Pointner (1), L. Lindner (1), G. Winter (2)
(1) Department of Internal Medicine III, University Hospital Munich, LMU, Munich, Germany; (2) Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, LMU, Munich, Germany

View Abstract

172 Liposomal Bortezomib for Targeted Proteasome Inhibition in Cancer
Presenter: Fens, Marcel. Authors: M. FENS (1), A. Deshantri (1), B. Metselaar (2), R. Schiffelers (1)
(1) University Medical Center Utrecht, Netherlands; (2) Enceladus pharmaceuticals, Netherlands

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173 Preliminary in vitro Testing of Novel Mucoadhesive and Mucopenetrating Polymeric Micelles and Nanogels as Platforms for Targeted Vaginal Delivery of Microbicides
Presenter: Yealland, Guy. Authors: R. CHARBAJI (1), N. Charbaji (2), G. Yealland (2), A. Bukchin (3), M. Calderón (2), A. Sosnik (4), S. Hedtrich (2)
(1) Institute for Pharmaceutical Sciences, Freie Universität Berlin, Germany; (2) Institute for Pharmaceutical Sciences, Freie Universität Berlin, Germany; (3) Department of Material Science and Engineering, Israel Institute of Technology, Israel; (4) Dep

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174 Two-step casting of dissolving MN arrays for use in the sustained release of rilpivirine for HIV pre-exposure prophylaxis
Presenter: Mc Crudden, Maeliosa. Authors: M. MC CRUDDEN (1), E. Larraneta (1), C. Jarrahian (2), R. Donnelly (1)
(1) Queen's University Belfast, United Kingdom; (2) PATH, U.S.A.

View Abstract

175 Novel pH-responsive polyurethane films for application on Intravaginal rings (IVRs)
Presenter: Kim, Seungil. Authors: S. KIM (1), Y. Chen (1), E. Ho (1), S. Liu (1)
(1) University of Manitoba, Canada

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176 Injectable Thermosensitive Gelling Delivery System for the Sustained Release of Lidocaine
Presenter: Sharma, Manisha. Authors: M. SHARMA (1), K. Chandramouli (1), P. Bhusal (1), Z. Wu (1), J. Alphonso (1), J. Chow (1), D. Patel (1), D. Svirskis (1), R. Ramakrishna (1), . Yeo (1), A. Hill (2), R. Stowers (3), J. Munro (3), S. Young (3)
(1) School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; (2) Department of Surgery, Middlemore Hospital, Faculty of Medicine and Health Sciences, University of Auckland,, New Zealand; (3) School of Medicine, Fac

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177 Gelatin Particle-Loaded Alginate Ferrogel for Controlled Drug Delivery
Presenter: Kim, Chunggu. Authors: C. KIM (1)
(1) Department of Bioengineering/Hanyang university, South Korea

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178 Mucoadhesive Acrylated Chitosan Nanoparticles for Delivery Through the Nasal Route
Presenter: Eliyahu, Shaked. Authors: S. ELIYAHU (1), A. Aharon (2), H. Bianco-Peled (3)
(1) The Russell Berrie Nanotechnology Institute, Technion, Israel; (2) Bruce Rappaport Faculty of Medicine, Technion, Israel; (3) Department of Chemical Engineering, Technion, Israel

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179 Gelatin Hydrogel Scaffolds for Co-delivery of Epirubicin and WWOX to Urothelium
Presenter: Chang, Li-Ching. Authors: L. CHANG (1), C. Liu (2), Y. Wu (2), Y. Yen (1)
(1) Department of Occupational Therapy, I-Shou University, Taiwan; (2) Faculty of Pharmacy, Kaohsiung Medical University, Taiwan

View Abstract

180 Novel pulmonary liposomal formulation with ultra-sensitivity against phospholipase A2
Presenter: Tagami, Tatsuaki. Authors: T. TAGAMI (1), T. Ozeki (1), Y. Ando (1)
(1) Nagoya City University, Japan

View Abstract

181 Development of Coenzyme Q10 Nano-Emulsions for a Nebulization Delivery
Presenter: Clise, Christina. Authors: G. CABANILLA (1)
(1) University of New Mexico College of Pharmacy, U.S.A.

View Abstract

182 Rational and strategic design of hydrogelators for controlled drug delivery
Presenter: Hassan, Md. Musfizur. Authors: M. HASSAN (1)
(1) University of New South Wales, Australia

View Abstract

183 Polyethylene Glycol Coating of Endotracheal Tubes for Local Therapy
Presenter: Le, Anh-Dung. Authors: A. LE (1), A. Padilla (1), J. Trujillo (1), J. Norenberg (1), J. McConville (1)
(1) University of New Mexico, U.S.A.

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184 Novel Dry Powder Inhaler containing the Nrf2 Activator Dimethyl Fumarate – Particle Engineering Design, Development and In Vitro Aerosol Dispersion Performance
Presenter: Muralidharan, Priya. Authors: P. MURALIDHARAN (1), D. Hayes (2), S. Black (1), H. Mansour (1)
(1) The University of Arizona, U.S.A.; (2) The Ohio State University, U.S.A.

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185 Does mucin binding have an effect on the inhaled disposition of ENaC blockers?
Presenter: Giorgetti, Melania. Authors: M. GIORGETTI (1), C. Morris (1), J. Angulo (1), D. Sandham (2), N. Smith (2), B. Cox (3)
(1) University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK, United Kingdom; (2) Novartis Institute of BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA, U.S.A.; (3) Department of Chemistry, University of Sussex, Brighton

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186 Therapeutic potential of thermosensitive liposomes for treatment of solid tumors: particle accumulation versus intravascular drug release
Presenter: Lokerse, Wouter. Authors: W. LOKERSE (1), M. Bolkestein (2), A. Eggermont (3), T. ten Hagen (2), H. Gruell (4), G. Koning (2)
(1) Ludwig Maximilians University Munich, Germany; (2) Erasmus MC, Netherlands; (3) Institut Gustave Roussy, France; (4) Technical University Eindhoven, Netherlands

View Abstract | View Presentation

187 Development of Novel Pulmonary Liposomal Delivery System of Afatinib Targeting Non-Small Cell Lung Cancer: In Vitro Characterization
Presenter: Almurshedi, Alanood. Authors: A. ALMURSHEDI (1), M. Radwan (2), M. Elkatib (3), G. Hutcheon (4), I. Saleem (4)
(1) KSU, Saudi Arabia; (2) PNU, Egypt; (3) KSU, Egypt; (4) LJMU, United Kingdom

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188 Novel Curcumin-loaded Nanocarrier for Pulmonary Delivery
Presenter: Nimmano, Nattika. Authors: N. NIMMANO (1), K. Taylor (1), S. Somavarapu (1)
(1) Department of Pharmaceutics, UCL School of Pharmacy, United Kingdom

View Abstract

189 Temperature sensitive liposomal doxorubicin combined with tumor ablation: effect of heating duration and administration schedule
Presenter: Haemmerich, Dieter. Authors: D. HAEMMERICH (1)
(1) Medical Univ. of South Carolina, U.S.A.

View Abstract | View Presentation

190 Development of an Enema Formulation for Rectal Administration of Magnesium Ions
Presenter: McAdams, David. Authors: D. MCADAMS (1)
(1) PATH, U.S.A.

View Abstract

191 Formulation of Stimuli-Sensitive Thiolated Hyaluronic Acid Based Nanofibers: Synthesis, Characterization, Preclinical Safety and In Vitro anti-HIV Activity
Presenter: Agrahari, Vivek. Authors: V. AGRAHARI (1), J. Meng (2), M. Ezoulin (2), Y. Ibrahima (2), D. Dim (2), A. Molteni (2), W. Hung (3), L. Christenson (3), B. Youan (2)
(1) University of Missouri-Kanss City, U.S.A.; (2) University of Missouri Kansas City, U.S.A.; (3) University of Kansas Medical Center, U.S.A.

View Abstract | View Presentation

192 Micro-composite drug delivery systems targeting lung cancer
Presenter: Osman, Rihab. Authors: R. OSMAN (1), R. Jatal (1), W. Mamdouh (2), G. Awad (1)
(1) Faculty of pharmacy, Ain Shams university, Egypt; (2) School of Science, American University in Cairo, Egypt

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193 Sodium Cholesteryl Sulfate - Curcumin Complexes for treatment of Lung Cancer
Presenter: Sornsute, Acom. Authors: A. SORNSUTE (1)
(1) UCL School of Pharmacy, United Kingdom

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194 Evaluation of Acid-labile PAMAM-Doxorubicin Conjugates on an in vitro Lung Adenocarcinoma Model and their Pseudo-Solution Formulation in Pressurized Metered-Dose Inhalers
Presenter: Zhong, Qian. Authors: Q. ZHONG (1), S. da Rocha (1)
(1) Virginia Commonwealth University, U.S.A.

View Abstract

195 Pulmonary Administration of Acid-Sensitive Poly(amidoamine)-Doxorubicin Conjugate Enhances Therapeutic Potency against Lung Metastases
Presenter: Zhong, Qian. Authors: Q. ZHONG (1), J. Reineke (2), S. da Rocha (1)
(1) Virginia Commonwealth University, U.S.A.; (2) South Dakota State University, U.S.A.

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196 Mounting Evidence of Pulmonary Nanoparticles as an Effective Lymphatic Targeting Delivery System
Presenter: Reineke, Joshua. Authors: J. REINEKE (1), Q. Zhong (2), M. Li (3), A. Mohammad (3), S. da Rocha (2)
(1) South Dakota State University, U.S.A.; (2) Virginia Commonwealth University, U.S.A.; (3) Wayne State University, U.S.A.

View Abstract | View Presentation

197 Reactive oxygen species (ROS) sensitive nanocomplex for tumor therapy
Presenter: Heo, Sukyoung. Authors: S. HEO (1)
(1) The catholic university of korea, South Korea

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198 Design of a vaginal thin film for extended release of an antiretroviral drug for HIV prevention
Presenter: Li, Jing. Authors: J. LI (1), L. Rohan (1)
(1) University of Pittsburgh, U.S.A.

View Abstract

199 Convection-enhanced delivery of radiosensitizing-nanoparticles for the treatment of intracranial glioma
Presenter: King, Amanda. Authors: A. KING (1), C. Corso (1), R. Bindra (1), W. Saltzman (1)
(1) Yale University, U.S.A.

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200 Gellan gum/retrograded starch microparticles ionically and dually cross-linked: evaluation of in vitro drug release and enzymatic digestion
Presenter: Oliveira Cardoso, Valéria Maria. Authors: M. DAFLON GREMIÃO (1), V. Oliveira Cardoso (1), B. S. Ferreira Cury (1)
(1) School of Pharmaceutical Sciences, São Paulo State Universit “Júlio de Mesquita Filho”, Brazil

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201 Peptide Dendrimer-Fe3O4 Nanoparticles with Enhanced Efficiency as Platforms for Combinatorial Thermo-Chemo Therapy
Presenter: Nigam, Saumya. Authors: S. NIGAM (1)
(1) IITB-Monash Research Academy, India

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202 Assessing Murine Immune Response to Pulmonary Delivery of Crystalline Rifapentine Particles
Presenter: Chan, Hak-Kim. Authors: T. PARUMASIVAM (1), A. Ashhurst (2), W. Britton (2), H. Chan (3)
(1) Faculty of Pharmacy, Australia; (2) Diseases and Immunology, Sydney Medical School, The University of Sydney, Australia; (3) University of Sydney, Australia

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203 Preparation and evaluation of gastro-retentive floating tablet for DA-9601, an extract of Artemisia Asiatica, for the treatment of gastric ulcer
Presenter: Kim, Ah-Young. Authors: K. CHA (1)
(1) Dong-A ST Pharmaceutical Co. Ltd., South Korea

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204 Cryogel formulation containing antibiotic and colony stimulating factor for local wound treatment
Presenter: Kotmakci, Mustafa. Authors: M. KOTMAKCI (1), H. Akbaba (1), I. Ozturk (2), G. Erel (1), E. Cucu (3), E. Tuncgenc (3)
(1) Ege Üniversity Faculty of Pharmacy Department of Pharmaceutical Biotechnology, Turkey; (2) Ege Üniversity Faculty of Pharmacy Department of Pharmaceutical Microbiology, Turkey; (3) Private Ege Higher School, Turkey

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205 Quantitative Design of a Yearly Progestin-Only Intravaginal Ring
Presenter: Karunakaran, Dipu. Authors: D. KARUNAKARAN (1), A. Evanoff (2), T. Yacoub (2), M. Clark (3), I. Szleifer (2), P. Kiser (2)
(1) Northwestern University,, U.S.A.; (2) Northwestern University, U.S.A.; (3) CONRAD, U.S.A.

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206 Silicone Intravaginal Rings for Codelivery of Macromolecular and Conventional Pharmaceuticals
Presenter: Petersen, Matthew. Authors: M. PETERSEN (1), J. Arps (1), K. Jain (1), S. Rios (1)
(1) Promed Pharma, U.S.A.

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638 HIGH EFFICIENT PHOTODYNAMIC THERAPY USING GAS GENERATING NANOPARTICLE AT TUMOR EXTRACELLULAR pH
Presenter: Lee, Jae Min. Authors: J. LEE (1), E. Ku (1), D. Kwag (1)
(1) Department of Biotechnology, The Catholic University of Korea, South Korea

View Abstract

640 The Inhibition of Gastric Mucosal Injury by Otillen F™, using a Gastroretentive Floating Drug Delivery System
Presenter: Shin, Yong Kwan. Authors: Y. SHIN (1)
(1) Daewon Pharmaceutical Company, South Korea

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collapse Manufacture, Characterization, Stability, and Regulatory Aspects

7 High-throughput synthesis and characterization of microcapsules
Presenter: Paul, Johan. Authors: J. PAUL (1), E. Bauters (1), P. Castelein (1), T. Parasote (1), G. Rivero (2), S. Cakir (2), F. Du Prez (2)
(1) Flamac, a division of SIM, Belgium; (2) Ghent University, Belgium

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8 Characterization of the Mechanical Strength, Adhesion and Leakage of Microcapsules for Developing Consumer Products
Presenter: Zhang, Zhibing. Authors: Z. ZHANG (1)
(1) University of Birmingham, United Kingdom

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208 Quantitative measurement of API coating level, with novel use of Videometer Multispectral Technology
Presenter: Wheadon, Craig. Authors: C. WHEADON (1)
(1) Catalent, United Kingdom

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209 Analysis of Cohesion Forces between Monodisperse Microparticles with Rough Surfaces
Presenter: Vehring, Reinhard. Authors: A. BALDELLI (1)
(1) University of Alberta, Canada

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210 Impact of Crystallization Kinetics on the Distribution of Chemical Components in Monodisperse Microparticles
Presenter: Vehring, Reinhard. Authors: A. BALDELLI (1)
(1) University of Alberta, Canada

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211 Investigation of a fully bioresorbable scaffold with coated eluted drug
Presenter: Mahmood, Tamara. Authors: T. MAHMOOD (1), C. Roberts (1), K. Al-Lamee (2), M. Alexnder (1), N. Bullett (2)
(1) University of Nottingham, United Kingdom; (2) Arterius Ltd, United Kingdom

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212 Formulation development and animal study of a ready to use intramuscular injection of penethamate for treatment of bovine mastitis
Presenter: Jain, Rohit. Authors: R. JAIN (1), O. Bork (1), I. Tucker (1)
(1) University of Otago, New Zealand

View Abstract

213 Low temperature hot melt extrusion processibility of ethylene vinyl acetate copolymers as pharmaceutical controlled release excipients
Presenter: Hair, Dirk. Authors: B. ZHANG (1), C. Schneider (1), J. Haley (1), D. Hair (1)
(1) Celanese, U.S.A.

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214 Modified release products from abbreviated new drug applications: Focus on Major deficiencies requiring reformulation
Presenter: Shah, Rakhi. Authors: R. SHAH (1)
(1) OPF/OPQ/CDER/FDA, U.S.A.

View Abstract

215 Physical Characteristics of Non-Ionic Surfactant Vesicles Prepared Using Different Manufacturing Methods
Presenter: Obeid, Mohammad. Authors: M. OBEID (1), A. . Mullen (1), R. Tate (1), V. Ferro (1)
(1) University of Strathclyde, United Kingdom

View Abstract | View Presentation

216 Influence of the type of emulsifier on the encapsulation and the release of the core material
Presenter: Scholz, Rebecca. Authors: R. SCHOLZ (1), L. Davico (1), T. Vöpel (1), S. Kareth (1), E. Weidner (2)
(1) Ruhr University Bochum, Germany; (2) Fraunhofer Institute UMSICHT, Germany

View Abstract

217 New Single Microparticle Technique for Forming and Characterizing Polymer Microsphere-Drug Encapsulation and Dissolution: Initial Tests for Ibuprofen-PLGA-DCM
Presenter: Kinoshita, Koji. Authors: K. KINOSHITA (1), E. Parra (1), A. Utoft (1), A. Hussein (1), T. Muala (1), H. Mohamud (1), D. Needham (1), P. Walke (1)
(1) University of Southern Denmark, Denmark

View Abstract | View Presentation

218 Channelling traditional analyses of liquid crystalline nanoparticles toward microfluidic approaches
Presenter: Hong, Linda. Authors: L. HONG (1), B. Boyd (1), Y. Dong (1), P. Spicer (2)
(1) Monash Institute of Pharmaceutical Science, Australia; (2) University of New South Wales, Australia

View Abstract

219 Gut on a chip–using microfluidics to probe structure formation during digestion of lipid-based formulations of poorly water soluble drugs
Presenter: Hong, Linda. Authors: L. HONG (1), B. Boyd (1), Y. Dong (1), P. Spicer (2)
(1) Monash Institute of Pharmaceutical Science, Australia; (2) University of New South Wales, Australia

View Abstract

220 Effect of Manufacturing Process on Critical Quality Attributes of Nlatrexone Microspheres
Presenter: Andhariya, Janki. Authors: J. ANDHARIYA (1), D. Burgess (1), J. shen (1), N. Swarnakar (1), W. Qu (2), Y. Wang (2), S. Choi (2)
(1) University of Connecticut, U.S.A.; (2) OGD, USFDA, U.S.A.

View Abstract

221 Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug
Presenter: Douroumis, Dennis. Authors: D. DOUROUMIS (1), M. Maniruzamman (1), A. Nair (2), N. Scoutaris (1)
(1) University of Greenwich, United Kingdom; (2) Fuji Chemical Industry Co., Ltd., Japan

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222 Continuous solid dispersions using co-processed Nesulin-solubulizers
Presenter: Douroumis, Dennis. Authors: D. DOUROUMIS (1), M. Maniruzamman (2), A. Nair (3)
(1) University of Greenwch, United Kingdom; (2) University of Sussex, United Kingdom; (3) Fuji Chemical Industry Co., Ltd., Japan

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223 One-step continuous extrusion process for the manufacturing of solid dispersions
Presenter: Douroumis, Dennis. Authors: D. DOUROUMIS (1), M. Maniruzamman (2), A. Nair (3)
(1) University of Greenwch, United Kingdom; (2) University of Sussex, United Kingdom; (3) Fuji Chemical Industry Co., Ltd., Japan

View Abstract

224 Novel polymeric stents manufactured by 3D printing technology
Presenter: Douroumis, Dennis. Authors: D. DOUROUMIS (1), N. Scoutaris (1), M. Bradley (1)
(1) University of Greenwich, United Kingdom

View Abstract

225 Jet dispensing as a high throughput method for rapid screening and manufacturing of cocrystals
Presenter: Douroumis, Dennis. Authors: D. DOUROUMIS (1), N. Scoutaris (1)
(1) University of Greenwich, United Kingdom

View Abstract | View Presentation

226 A scalable microfluidics platform for the development of lipid nanoparticles
Presenter: Lockard, Ray. Authors: R. LOCKARD (1), K. Ou (1), J. Singh (1), G. Heuck (1), S. Ip (1), E. Ouellet (1), A. Thomas (1), T. Leaver (1), A. Wild (1), J. Taylor (1), S. Garg (1), E. Ramsay (1)
(1) Precision NanoSystems, Inc., Canada

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227 Microfluidics enables the seamless manufacture of RNA-lipid nanoparticles from microliters to liters
Presenter: Garg, Shyam. Authors: S. GARG (1), K. Marshall (1), S. Sidhu (1), M. Ma (1), A. Kritharis (1), D. Droubi (1), E. Ouellet (1), A. Thomas (1), T. Leaver (1), A. Wild (1), J. Taylor (1), E. Ramsay (1)
(1) Precision NanoSystems, Inc., Canada

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228 Scaling Taste-Masked Dispersed Dosage Forms for Pediatric & Geriatric Use
Presenter: Rice, Jamie. Authors: N. DORMER (1), M. Teresk (1), C. Shoults (1), C. Berkland (1)
(1) Orbis Biosciences, U.S.A.

View Abstract

229 Surface Functionalization of Novel Methotrexate loaded Chitosan Nanoparticles with Hyaluronic acid/Human serum albumin: Comparative characterization and in vitro cytotoxicity
Presenter: A.H. Ishak, Rania. Authors: R. HASHAD (1), R. Ishak (1), S. Mansour (1), A. Geneidi (1)
(1) Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Egypt

View Abstract

230 Analysis the responses of human bitterness receptor agonists toward taste sensors
Presenter: Haraguchi, Tamami. Authors: T. UCHIDA (1), M. Yoshida (1), T. Haraguchi (1), H. Kojima (1), M. Habara (2), H. Ikezaki (3)
(1) Mukogawa Women's University, Japan; (2) Intelligent Sensor Technology Inc., Japan; (3) Intelligent Sensor Technology, Japan

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231 Physical Assessment of a 3D Printed Polylactic Acid Dart for Wildlife Contraceptive Delivery
Presenter: Bunt, Craig. Authors: C. BUNT (1), K. Pickering (2), J. Long (3), H. Gholizadeh (3), A. Seyfoddin (3)
(1) Lincoln University, New Zealand; (2) Waikato University, New Zealand; (3) Auckland University of Technology, New Zealand

View Abstract

232 Why Choose Small Sugar Spheres?
Presenter: LaBella, Gus. Authors: G. LABELLA (1), J. Hansell (2), S. Vass (2)
(1) Colorocn Inc., U.S.A.; (2) Colorcon Inc., U.S.A.

View Abstract

233 Activated Carbon Based Disposal of Fentanyl Transdermal Patches
Presenter: Bakshi, Pooja. Authors: P. BAKSHI (1), B. Fowler (1), A. Korey (1)
(1) Verde Technologies, U.S.A.

View Abstract

234 Mass production of an anti-atherosclerotic drug-loaded nanoparticle for evaluation in large animals
Presenter: Fay, Francois. Authors: F. FAY (1), R. Duivenvoorden (2), T. Binderup (3), Z. Fayad (4), C. Perez-medina (4), W. Mulder (4)
(1) Translational and Molecular Imaging Institute, Icahn School Icahn School of Medicine at Mount Sinai, U.S.A.; (2) Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands, Netherlands; (3) Department of Medical Biochemist

View Abstract

235 Print-Drying: Monodisperse Droplet Spray-Drying & High Quality Powder Production
Presenter: Salari, Joris. Authors: J. SALARI (1)
(1) TNO, Netherlands

View Abstract | View Presentation

236 Development of a novel in vitro release test method for a polymeric micelle formulation for paclitaxel, Genexol®-PM
Presenter: Lee, Sa-Won. Authors: G. Kim (1), H. Jang (1), Y. Yi (1), M. Seo (1)
(1) Samyang Biopharmaceuticals Corporation, Korea

View Abstract

237 Assessment of nimodipine oral Self-emulsified delivery systems using an in vitro lipolysis model
Presenter: Zidan, Ahmed. Authors: A. ZIDAN (1), A. Alayoubi (1), Z. Rahman (1), M. Ashraf (1), C. Cruz (1)
(1) FDA, U.S.A.

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238 Multivariate DoE & Live in-situ Dissolution Monitoring: Strategy for Reverse Engineering Success.
Presenter: Webb, Travis. Authors: T. WEBB (1), J. Maxwell (1), M. Favero (1), B. Hilker (1), J. Cacace (1)
(1) CoreRx, U.S.A.

View Abstract

239 Assay of PLGA Properties in Parenteral Depot Formulations
Presenter: Garner, John. Authors: J. GARNER (1), S. Skidmore (1), H. Park (1), K. Park (1), S. Choi (2), Y. Wang (3)
(1) Akina, Inc., U.S.A.; (2) FDA CDER, U.S.A.; (3) FDA, U.S.A.

View Abstract
collapse Mini Symposia: Developing Therapeutic Options for Combating Cancer: A “One Health” Challenge for Humans and Dogs”

9 Defining the value of comparative oncology: The NCI Comparative Oncology Program and companion species clinical trials
Presenter: Vail, David. Authors: D. VAIL (1), A. Leblanc (2)
(1) School of Veterinary Medicine, University of Wisconsin-Madison, U.S.A.; (2) Comparative Oncology Program, Center for Cancer Research, NCI, U.S.A.

View Abstract | View Presentation
collapse New Processes, New Materials, New Products

10 Rationally Designed Carbon Nanostructures: New Processes for New Applications
Presenter: Al-Jamal, Khuloud. Authors: K. Al-JAMAL (1)
(1) Institute of Pharmaceutical Science, King’s College London, UK

View Abstract

240 Three-dimensional micro-patterning of biodegradable polymers for controlled drug delivery
Presenter: Nguyen, Thanh. Authors: T. NGUYEN (1), A. Jaknelec (2), R. Langer (2)
(1) University of Connecticut, U.S.A.; (2) Massachusetts Institute of Technology, U.S.A.

View Abstract

241 Aripiprazole loaded in situ forming implant; an innovative alternative for treatment of schizophrenia
Presenter: Dorkoosh, Farid. Authors: F. DORKOOSH (1), A. Hedayati (1), P. Dehghankelishadi (2), N. Bahari Javan (1)
(1) Tehran University of Medical Sciences, Iran; (2) Tehran University of Medical Sciences, Medical Biomaterial Research Center, Iran

View Abstract

242 Tumor acidity sensitive polymeric micelle for selective cellular uptake of doxorubicin
Presenter: Hiruta, Yuki. Authors: Y. HIRUTA (1), Y. Nagata (1), R. Nemoto (1), H. Kanazawa (1)
(1) Keio University, Japan

View Abstract | View Presentation

243 Nitric Oxide: A key player for novel anti-cancer immunotherapeutics
Presenter: Nagasaki, Yukio. Authors: Y. NAGASAKI (1), K. Shinpei (1)
(1) University of Tsukuba, Japan

View Abstract | View Presentation

244 Effect of Shape and Surface Property of Thermoresponsive Core-corona Type Nanoparticles on Phagocytosis
Presenter: Kikuchi, Akihiko. Authors: A. KIKUCHI (1), T. Suzuki (1), T. Matsuyama (1), R. Ishihara (1)
(1) Tokyo University of Science, Dept. Mater. Sci. & Technol., Japan

View Abstract

245 Size Reduction of Amine Containing, Temperature Sensitive Nanogels Prepared by Soapless Emulsion Polymerization
Presenter: Castro Marin, Rafael Alejandro. Authors: R. CASTRO MARIN (1), A. Serrano Medina (1), A. Vea Barragán (2), J. Cornejo Bravo (2)
(1) Autonomous University of Baja California, Mexico; (2) Autonomous University of Baja California , Mexico

View Abstract

246 Benzoic imine bond based pH sensitive polycations as effective gene carriers
Presenter: Cheng, Yilong. Authors: Y. CHENG (1), D. Sellers (1), K. Tan (1), D. Peeler (1), S. Pun (1)
(1) University of Washington, U.S.A.

View Abstract

247 Coupling 3D Printing with Hot Melt Extrusion Technology to Continuously Produce Controlled Release Tablets
Presenter: Tiwari, Roshan. Authors: M. REPKA (1), J. Zhang (1), R. Tiwari (1), X. Feng (2), H. Patil (1)
(1) Department of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS 38677, U.S.A.; (2) Department of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS 38677, U.S.A.

View Abstract | View Presentation

248 Transformable Liquid-Metal Nanomedicine
Presenter: Lu, Yue. Authors: Y. LU (1), Q. Hu (1), Y. Lin (2), F. Ligler (1), M. Dickey (2), Z. Gu (1)
(1) University of North Carolina at Chapel Hill and North Carolina State University, U.S.A.; (2) North Carolina State University, U.S.A.

View Abstract | View Presentation

249 Hypromellose as a solubility enhancer for poorly soluble drugs
Presenter: Lee, Sang Youb. Authors: K. SHIN (1), S. Lee (1), J. Son (1)
(1) Lotte Fine Chemicals, Korea

View Abstract

250 Paclitaxel-Nanodiamond complexes enhances dispersity and drug retention in cells
Presenter: Lim, Dae Gon. Authors: D. LIM (1), E. Kang (2), S. Jeong (3)
(1) Dongguk University, South Korea; (2) Chung-Ang University, Korea; (3) Dongguk University, Korea

View Abstract

251 Biodegradable Functional Polycarbonate Micelles for Controlled Systemic Release of Amphotericin B
Presenter: Wang, Ying. Authors: Y. WANG (1), X. Ke (2), Z. VOO (2), S. Yap (3), C. Yang (2), S. VENKATARAMAN (2), Y. Yang (2), P. EE (3)
(1) National University of Singapore, Singapore; (2) Institute of Bioengineering and Nanotechnology, Singapore; (3) Department of Pharmacy, NUS, Singapore

View Abstract

252 Structure Analysis of Drug Delivery Systems with SAXS in the LabORATORY
Presenter: Langenbucher, Gerd. Authors: G. LANGENBUCHER (1), A. Pichler (2)
(1) Anton Paar USA, Inc., U.S.A.; (2) Anton Paar GmbH, Austria

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253 ElectroNanospray™: Realizing the Benefits of Being Nano-Sized and Amorphous
Presenter: Wertz, Christian. Authors: C. WERTZ (1), R. Hoerr (1), H. Chen (1), D. Thao (1), C. Batty (1)
(1) Nanocopoeia, U.S.A.

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254 Latent, Heat-Activated ROMP Curing Polyester Thermosets for Encapsulation
Presenter: Baumgartner, Ryan. Authors: R. BAUMGARTNER (1), K. Ryba (1), Z. Song (1), R. Wang (1), J. Cheng (1)
(1) University of Illinois at Urbana-Champaign, U.S.A.

View Abstract

255 Delivery of Transmembrane Proteins Using Cell-derived Biovesicles
Presenter: Ferrati, Silvia. Authors: S. FERRATI (1), A. Gadok (1), L. Heersema (1), A. Brunaugh (1), H. Smyth (1)
(1) The University of Texas at Austin, U.S.A.

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256 Microfluidics-based manufacture of PLGA nanoparticles for the encapsulation and release of small molecule therapeutics
Presenter: Garg, Shyam. Authors: S. GARG (1), A. Thomas (1), J. Singh (1), G. Heuck (1), S. Ip (1), T. Leaver (1), A. Wild (1), J. Taylor (1), E. Ramsay (1)
(1) Precision NanoSystems, Inc., Canada

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257 Evaluation of Newly-Developed Hypromellose Acetate Succinate (HPMCAS) for Spray Dried Solid Dispersions of Poorly-Soluble Drugs
Presenter: Tewari, Divya. Authors: Q. SCHWING (1), M. Davis (1), D. Tewari (1), T. Dürig (1)
(1) Ashland Specialty Ingredients, U.S.A.

View Abstract

258 Synthesis and characterization of a novel Mycophenolic Acid - Quinic Acid conjugate as an immunosuppressant
Presenter: Peng, Yang. Authors: Y. PENG (1), Y. Dong (1), R. Mahato (1)
(1) University of Nebraska Medical Center, U.S.A.

View Abstract

259 Producing Drug Delivering Multicompartmental Polymer Particles Using High Shear Fluid Processing Technology
Presenter: Su, Yang. Authors: Y. SU (1), K. Jandrasitz (1), C. Newbold (1), S. Mesite (1), G. Matthaiolampakis (2), G. Ahmad (2), M. Amiji (2)
(1) Microfluidics International Corporation, U.S.A.; (2) Northeastern University, U.S.A.

View Abstract

260 Design and Fabrication of Nanoreactor for Continuous Generation of Nanoparticles: QbD Approach
Presenter: Gite, Sandip. Authors: S. GITE (1), V. Patravale (1)
(1) Institute of chemical technology, India

View Abstract

261 Nano-Fiber Formulations for Oral Controlled-Release DDS Based on Electrospinning Method
Presenter: Shibata, Nobuhito. Authors: N. SHIBATA (1), M. Hamori (1), Y. Kamo (1), K. Kitazawa (1), Y. Saito (1), A. Kiriyama (1), A. Nishimura (1)
(1) Doshisha Women’s College of Liberal Arts, Faculty of Pharmaceutical Science, Japan

View Abstract

262 Microfluidics enables manufacture of liposomes of defined size for the encapsulation of small molecule therapeutics
Presenter: Garg, Shyam. Authors: S. GARG (1), A. Thomas (1), J. Singh (1), G. Heuck (1), S. Ip (1), T. Leaver (1), A. Wild (1), J. Taylor (1), E. Ramsay (1)
(1) Precision NanoSystems, Inc., Canada

View Abstract

263 Functional Polymers for Drug Delivery Applications
Presenter: Panambur, Gangadhar. Authors: G. PANAMBUR (1), D. Koo (1), S. Rehman (1)
(1) MilliporeSigma, U.S.A.

View Abstract | View Presentation

264 Microstructured NIPAAm hydrogels with Fast Response and Adjusted Transition Temperature for Positive Control Release
Presenter: Palomino Vizcaino, Kenia. Authors: K. PALOMINO VIZCAINO (1), P. Cervantes (1), H. Magaña (1), A. Serrano (1), J. Cornejo (1)
(1) Autonomous University of Baja California, Mexico

View Abstract

265 Development and Evaluation a Novel Drug Delivery Carrier for Anticancer Therapy
Presenter: Song, Yunmei. Authors: Y. SONG (1)
(1) University of South Australia, Australia

View Abstract

267 Tumor pH-responsive, multi-armed polymeric photosensitizer
Presenter: Jo, Young-Um. Authors: Y. JO (1), K. Na (1)
(1) The Catholic University of Korea, Korea

View Abstract

268 The Microfluidic Production of High Efficiency PEI/DNA Polyplexes
Presenter: Absher, Jason. Authors: J. ABSHER (1)
(1) University of Kentucky, U.S.A.

View Abstract
collapse Ocular Drug Delivery

11 Silicon-Based Nanomaterials for Ocular Drug Delivery
Presenter: Sailor, Michael. Authors: M. SAILOR (1), J. Wang (1), T. Kumeria (1), L. Cheng (1), H. Hou (1), W. Freeman (1)
(1) University of California, San Diego, U.S.A.

View Abstract | View Presentation

12 Bridging Product Design and Performance for Bioequivalence: A Journey through the Eye
Presenter: Xu, Xiaoming. Authors: X. XU (1)
(1) U.S. FDA, U.S.A.

View Abstract | View Presentation

13 An Update on FDA’s Research Program for Ophthalmic Generic Products
Presenter: Choi, Stephanie. Authors: S. CHOI (1)
(1) FDA, U.S.A.

View Abstract | View Presentation

269 Smart Wireless Contact Lens for Ocular Theranosis
Presenter: Keum, Dohee. Authors: D. KEUM (1), S. Hahn (1)
(1) POSTECh, Korea

View Abstract | View Presentation

270 Ultradeformable bilosomes for enhanced ocular delivery of terconazole: In vitro characterization and factorial analysis
Presenter: Abdelbary, Aly. Authors: A. ABDELBARY (1), A. Al-mahallawi (1), W. Abd-Elsalam (1)
(1) Faculty of Pharmacy-Cairo University, Egypt

View Abstract

271 Ultrasound-responsive nanobubbles for enhanced posterior eye delivery of therapeutics
Presenter: Thakur, Sachin. Authors: S. THAKUR (1), H. Parekh (1), I. Rupenthal (2), E. Chen (2)
(1) School of Pharmacy, the University of Queensland, Australia; (2) Buchanan Ocular Therapeutics Unit, School of Medicine, the University of Auckland, New Zealand

View Abstract | View Presentation

272 Extended Release Cysteamine Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis
Presenter: Marcano, Daniela. Authors: D. MARCANO (1), C. Shin (1), B. Lee (2), L. Isenhart (1), F. Li (1), J. Jester (2), S. Pflugfelder (1), J. Simpson (2), G. Acharya (1)
(1) Baylor College of Medicine, U.S.A.; (2) University of California, U.S.A.

View Abstract

273 Convective loading and release of latanoprost via a silicone hydrogel contact lens in vitro
Presenter: Pitt, William. Authors: R. HORNE (1), W. Pitt (1), K. Judd (1)
(1) Brigham Young University, U.S.A.

View Abstract

274 Retinylamine Modified Multifunctional Lipid DNA Delivery System for the Treatment of LCA2
Presenter: Sun, Da. Authors: D. SUN (1), B. Sahu (2), S. Gao (2), A. Maeda (2), K. Palczewski (2), Z. Lu (2)
(1) Case Western Reserve University, U.S.A.; (2) Case Western Reserve Univserity, U.S.A.

View Abstract

275 Potential Preclinical Approaches to Establish Bioequivalence of Ophthalmic Products
Presenter: Bhyrapuneni, Gopinadh. Authors: G. BHYRAPUNENI (1), V. Benade (1), G. Ayyanki (1), V. Kamuju (1), S. Daripelli (1), R. Ponnamaneni (1), A. Manoharan (1), S. Irappanavar (1), N. Muddana (1), R. Nirogi (1)
(1) Suven Life Sciences Limited, India

View Abstract

276 Flexible Formulating for Problem Therapeutics
Presenter: Groves, Rhian. Authors: R. GROVES (1), P. Seaman (1)
(1) Midatech Pharma, United Kingdom

View Abstract

277 OpsiSporin -  Development of Controlled Release Cyclosporin for the treatment of posterior uveitis
Presenter: Bamsey, Katherine. Authors: K. BAMSEY (1), P. Seaman (1), R. Groves (1)
(1) Midatech Pharma, United Kingdom

View Abstract | View Presentation

278 Dextran Sulfate Wafer as an Anti-Angiogenic Polymer Therapeutic
Presenter: Shin, Crystal. Authors: C. SHIN (1), X. Yuan (1), D. Marcano (1), L. Isenhart (1), K. Simmons (1), S. Pflugfelder (1), G. Acharya (1)
(1) Baylor College of Medicine, U.S.A.

View Abstract | View Presentation

279 Composite Nanotherapeutics for Long Term Ocular Delivery of Macromolecules
Presenter: Agrahari, Vibhuti. Authors: V. AGRAHARI (1), V. Agrahari (2), W. Hung (3), L. Christenson (3), A. Mitra (2)
(1) University of Missouri-Kanss City, U.S.A.; (2) University of Missouri Kansas City, U.S.A.; (3) University of Kansas Medical Center, U.S.A.

View Abstract

280 Template Directed Chemical Polymerization of Electroactive Polypyrrole Particles Loaded With Dexamethasone
Presenter: Uppalapati, Dedeepya. Authors: D. UPPALAPATI (1), M. Sharma (1), Z. Agrawe (1), B. Boyd (2), J. Travas-Sejdic (1), D. Svirskis (1)
(1) The University of Auckland, New Zealand; (2) Monash Univeristy, Australia

View Abstract

281 Controlled Release of Avastin® from the Tethadur™ Biodegradable Matrix
Presenter: Kelly, Catherine. Authors: C. KELLY (1), D. Nadarassan (1), K. Webb (1), Q. Shabir (1), H. O'Brien (1), C. Storey (1), A. Loni (1), L. Canham (1)
(1) PsiMedica, United Kingdom

View Abstract | View Presentation
collapse Oligonucleotide Delivery: New Applications and Opportunities

14 Engineering Cyclodextrin Nanoparticles for the Delivery of siRNA
Presenter: Geall, Andrew. Authors: A. GEALL (1)
(1) Avidity NanoMedicines, U.S.A.

View Abstract

15 Design of lipid nanoparticle delivery systems to enable therapeutic applications of siRNA and mRNA
Presenter: Cullis, Pieter. Authors: P. CULLIS (1)
(1) University of BC, Canada

View Abstract | View Presentation

282 Exploring MicroRNA Expression Profiles Related to Cell Death Pathways in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine
Presenter: Kuo, Jung-hua. Authors: J. KUO (1), M. Jan (2), C. Lin (2)
(1) Department of Pharmacy, Chia Nan University of Pharmacy and Science, Taiwan; (2) Institute of Microbiology and Immunology, Chung Shan Medical University, Taiwan

View Abstract

283 Dual-sensitive mixed-micelles for co-delivery of miRNA 34a and doxorubicin into tumor cells
Presenter: Costa, Daniel. Authors: D. COSTA (1), G. Salzano (1), C. Sarisozen (1), E. Luther (1), P. Dhargalkar (1), G. Mattheolabakis (1), V. Torchilin (1)
(1) Northeastern University, U.S.A.

View Abstract

284 Design and evaluation of a stearylated multicomponent peptide for siRNA delivery
Presenter: Wan, Yu. Authors: Y. WAN (1), P. Moyle (1), I. Toth (1)
(1) The University of Queensland, Australia

View Abstract

285 Stabilization of Oligonucleotide-loaded Gelatin Nanoparticles by Lyophilization
Presenter: Geh, Katharina. Authors: K. GEH (1), M. Hubert (2), G. Winter (1)
(1) LMU München, Germany; (2) Umea University, Sweden

View Abstract

286 A Novel Mechanistic Approach for the Treatment of Cisplatin Resistant Ovarian Cancer Using a RNAi Nanomedicine Based Platform Targeting  DJ-1 in Combination with Cisplatin
Presenter: Schumann, Canan. Authors: C. SCHUMANN (1), S. Chan (1), V. Shah (1), S. Khal (2), O. Taratula (1)
(1) Oregon State University, U.S.A.; (2) Portland State University, U.S.A.

View Abstract

287 Targeted gene silencing in cancer cells using anti-CD44 aptamer-functionalized liposomes
Presenter: Fattal, Elias. Authors: E. FATTAL (1), W. El Shaer (2), H. Hillaireau (2), J. Vergnaud (2), S. Ismail (3)
(1) University Paris-Sud/Institut Galien Paris-Sud, France; (2) University Paris Sud/Institut Galien Paris Sud, France; (3) University of Amman, Jordan

View Abstract

288 Inspired by Nature: Characterization of Mechanisms of Extracellular Vesicle Uptake
Presenter: Vader, Pieter. Authors: P. VADER (1), H. Costa Verdera (1), J. Gitz-Francois (1), R. Schiffelers (1)
(1) University Medical Center Utrecht, Netherlands

View Abstract

289 Development of an in silico Model for Estimation of Regional Absorption in Lower Gut for Oral Controlled-Release Formulations
Presenter: Zhu, Wei. Authors: W. ZHU (1), T. Vora (2), M. Milewski (1), F. Kesisoglou (1)
(1) Biopharmaceutics, Pharmaceutical Sciences and Clinical Supply, Merck & Co., U.S.A.; (2) Division of Pharmaceutical Sciences, Long Island University, U.S.A.

View Abstract

290 DOPE-PEI-coated liposome for co-delivery of paclitaxel and siRNA
Presenter: Pan, Jiayi. Authors: J. PAN (1), L. P. Mendes (1), C. Sarisozen (1), V. Torchilin (1)
(1) Center for Pharmaceutical Biotechnology and nanomedicine, Northeastern University, U.S.A.

View Abstract

291 Improving RNAi-mediated Gene Silencing of Chemically Modified siRNA-GalNAc Conjugate Using Phosphate Mimic
Presenter: Parmar, Rubina. Authors: R. PARMAR (1), C. Theile (1), J. Willoughby (1), D. Foster (1), J. O’Shea (1), N. Taneja (1), K. Charisse (1), V. Jadhav (1), M. Manoharan (1), M. Maier (1), K. Rajeev (1)
(1) Alnylam Pharmaceuticals, U.S.A.

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292 Investigating the Interior of Lipid Nanoparticles for mRNA Delivery by Surface Enhanced DNP-NMR
Presenter: Schantz, Staffan. Authors: S. SCHANTZ (1), J. Viger-Gravel (2), A. Schantz (1), A. Rossini (3), A. Pinon (2), L. Emsley (2)
(1) AstraZeneca R&D Mölndal, Sweden; (2) EPFL Lausanne, Switzerland; (3) Iowa state University, U.S.A.

View Abstract | View Presentation

293 Peptide-based Multicomponent Oligonucleotide Delivery Systems: Optimisation of Poly-L-lysine Dendrons for Plasmid DNA Delivery
Presenter: Kamaruzaman, Khairul Azfar. Authors: K. KAMARUZAMAN (1), P. Moyle (2), I. Toth (3)
(1) School of Chemistry and Molecular Biosciences, University of Queensland, Australia; (2) School of Pharmacy, University of Queensland, Australia; (3) School of Chemistry and Molecular Biosciences, Univeristy of Queensland, Australia

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294 Functional Gene Delivery System based on Porous Silica Nanoparticle with Tunable Pore Size
Presenter: Kim, Seongchan. Authors: S. KIM (1), D. Min (1)
(1) Seoul National University, South Korea

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295 Functionally-tailorable Synthetic Carrier of Nucleic Cids Formed from Single Molecule of Cationic Polymer through Rational Assembly
Presenter: Jin, Tuo. Authors: T. JIN (1), S. Chen (1), J. Feng (1), G. Bai (1)
(1) Shanghai Jiao Tong University, China

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296 Hypoxia-responsive siRNA delivery system for tumor-targeted therapy
Presenter: Kang, Lin. Authors: L. KANG (1), B. Fan (1), W. Huang (1), Q. Wang (1), M. Jin (1), Z. Gao (1)
(1) Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, China

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297 Effective transfection of siRNA Using Temperature Responsive Liposome
Presenter: Wang, Jian. Authors: J. WANG (1), M. Hasegawa (1), E. Ayano (1), Y. Maitani (1), H. Kanazawa (1)
(1) Keio University, Japan

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298 Liposomal Delivery of miRNA against Herpes Simplex Virus 1
Presenter: Golomb, Gershon. Authors: G. GOLOMB (1), A. Giterman (1), O. Feldman (1), A. Dagan (1), A. Kühbacher (2), S. Rupp (2)
(1) The Hebrew University of Jerusalem, Israel; (2) Fraunhofer Institute, Germany

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299 Coiled-coil functionalized liposomes for the targeting of liposomes for gene delivery
Presenter: Oude Blenke, Erik. Authors: E. OUDE BLENKE (1), J. van den Dikkenberg (1), B. van Kolck (2), A. Kros (2), E. Mastrobattista (1)
(1) Utrecht University, Netherlands; (2) Leiden University, Netherlands

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300 Biodegradable Dendritic Lipid Nanoparticles for Small RNA Delivery to Treat Gynecologic Cancers
Presenter: Kos, Petra. Authors: P. KOS (1), K. Zhou (1), J. Minnig (1), M. White (1), D. Siegwart (1)
(1) UT Southwestern Medical Center, U.S.A.

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301 Combinatorial mTORC2 RNAi and lapatanib for treatment of HER2-amplified breast cancer
Presenter: Duvall, Craig. Authors: C. DUVALL (1), T. Werfel (1), D. Brantley-Sieders (1), M. Jackson (1), T. Kavanaugh (1), M. Morrison (1), D. Hicks (1), R. Cook (1)
(1) Vanderbilt University, U.S.A.

View Abstract | View Presentation

302 Magnetic Nanocomplex-Mediated Gene Delivery on Mesenchymal Stem Cells and Applications on Glioma Treatment
Presenter: Chang, Chien-Wen. Authors: R. HUANG (1), Y. Lin (1), S. Lin (1), C. Chang (1)
(1) Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Taiwan

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303 Synthesis of Poly(arginine-histidine) peptides modified chitosan nanoparticles for siRNA delivery targeting 4T1 cancer
Presenter: Sun, Ping. Authors: P. SUN (1), Z. Gao (1)
(1) Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, China

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304 Tumor environment-sensitive nanocarrier for siRNA
Presenter: Palmerston Mendes, Livia. Authors: L. PALMERSTON MENDES (1), T. Kanazawa (2), C. Sarisozen (1), V. P. Torchilin (1)
(1) Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, U.S.A.; (2) Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan

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305 Microfluidics-based manufacture of siRNA-Lipid nanoparticles: A potent tool for silencing neuronal gene expression in vitro and in vivo
Presenter: Garg, Shyam. Authors: E. OUELLET (1), G. Tharmarajah (1), D. Droubi (1), S. Garg (1), O. Seira (2), J. Liu (2), A. Thomas (1), T. Leaver (1), A. Wild (1), Y. Li (2), Y. Wang (2), W. Tetzlaff (2), P. Cullis (2), J. Taylor (1), E. Ramsay (1)
(1) Precision NanoSystems, Inc., Canada; (2) University of British Columbia, Canada

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306 Activated poly(amine-co-ester) terpolymers for EPO mRNA delivery
Presenter: Gaudin, Alice. Authors: A. GAUDIN (1), J. Zhang (1)
(1) Biomedical Engineering Department, Yale University, U.S.A.

View Abstract

307 Antisense oligonucleotide delivery using complementary DNA nanostructures
Presenter: Oh, Yu-Kyoung. Authors: Y. OH (1), M. Kim (1), J. Park (1), G. Shim (1)
(1) Seoul National University, South Korea

View Abstract | View Presentation

308 Microfluidic Mixing of Nanoparticle-based siRNA Therapeutics
Presenter: Feldmann, Daniel. Authors: D. FELDMANN (1), O. Merkel (1)
(1) Wayne State University, U.S.A.

View Abstract

309 Gene silencing using chitosan oligosaccharide-siRNA nanoplexes for alleviating lung diseases
Presenter: Koli, Uday. Authors: U. KOLI (1), P. Bhartiya (2), D. Modi (2), R. Jain (1), P. Dandekar (1)
(1) Institute of Chemical Technology, India; (2) National Institute of Research in Reproductive Health, India

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310 Liver-specific delivery of a novel DNA/RNA heteroduplex oligonucleotide via enteral routes produced by the combination of a-tocopherol conjugation and permeation enhancers.
Presenter: Watanabe, Chie. Authors: C. WATANABE (1), Y. Cheng (1), A. Watari (2), M. Kondoh (2), M. Murakami (1), T. Yokota (3), K. Yagi (2), K. Nishina (3), Y. Matsumoto (4), K. Toh (5), K. Yoshida-Tanaka (3), S. Obika (2), K. Kataoka (6), K. Miyata (6)
(1) Osaka Ohtani University, Japan; (2) Osaka University, Japan; (3) Tokyo Medical and Dental University, Japan; (4) Tokyo Univesity, Japan; (5) Tokyo University, Japan; (6) The University of Tokyo, Japan

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311 Ultrasound Mediated EGFR siRNA Delivery Using a Liposome-Microbubble Complex Inhibits Tumor Growth
Presenter: Qin, Bin. Authors: B. QIN (1), X. Chen (1), J. Kopechek, (1), B. Helfield (1), F. Yu (1), J. Cyriac (1), L. Lavery (1), F. Villanueva (1)
(1) University of Pittsburgh, U.S.A.

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312 MicroRNA nanoparticles: Electrophoretic and dynamic light scattering technology predict colloidal stability
Presenter: Usack, Krystopher. Authors: B. PETRILLO (1), A. Schachner-Nedherer (2), S. Holzinger (2), A. Zimmer (2)
(1) Anton Paar GmbH, Austria; (2) University of Graz, Austria

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313 Bombesin/oligoarginine fusion peptide as delivery system for targeted delivery of oligonucleotide
Presenter: Begum, Anjuman. Authors: A. BEGUM (1)
(1) The University of Queensland, Australia

View Abstract

314 Targeted Di-Block Polymers Deliver mRNA to the Liver for the Treatment of Urea Cycle Disorders
Presenter: Roy, Debashish. Authors: D. ROY (1)
(1) PhaseRx, U.S.A.

View Abstract

315 Oligospermines as Nucleic Acid Carrires
Presenter: Darwich, Banan. Authors: B. DARWICH (1), A. Datar (2)
(1) UIC, U.S.A.; (2) University of Illinois College of Medicine at Rockford, U.S.A.

View Abstract
collapse Oral Delivery

16 Recent developments in locally acting gastrointestinal drugs with an emphasis on how to determine local drug dissolution
Presenter: Khan, Mansoor. Authors: M. KHAN (1)
(1) Texas A&M Health Science Center, U.S.A.

View Abstract | View Presentation

17 Understanding Critical Excipient Properties to Ensure Consistent Quality of Amorphous Solid Dispersion and Extended-Release Products
Presenter: Qiu, Yihong. Authors: Y. QIU (1)
(1) AbbVie, U.S.A.

View Abstract | View Presentation

316 In vivo dual-delivery of GLP-1 and DPP4 inhibitor through composites prepared by microfluidics for diabetes therapy
Presenter: Araújo, Francisca. Authors: F. ARAÚJO (1), N. Shrestha (2), M. Gomes (1), D. Liu (2), J. Hirvonen (2), P. Granja (1), H. Santos (2), B. Sarmento (1)
(1) INEB, Portugal; (2) Faculty of Pharmacy, University of Helsinki, Finland

View Abstract

317 Oral soluplusR based Scopoletin micelles for acute hyperuricemic therapy
Presenter: Zeng, Yingchun. Authors: Y. ZENG (1)
(1) West China School of Pharmacy, Sichuan University, China

View Abstract

318 Coating effects of mucoadhesive polymers on solid lipid nanoparticles for oral drug delivery
Presenter: Ramalingam, Prakash. Authors: P. RAMALINGAM (1), K. Ji Hee (1), K. Young Tag (1)
(1) Gachon University, South Korea

View Abstract

319 Oral Delivery of Insulin by Zwitterions Functionalized NP through Overcoming Multiple Barriers
Presenter: Shan, Wei. Authors: W. SHAN (1), Y. Huang (1)
(1) West China School of Pharmacy, Sichuan University, China

View Abstract

320 Rational Selection of Polymeric Carriers for Spray-Dried Dispersion of a Highly Hydrophobic Drug
Presenter: Bi, Vivian. Authors: V. BI (1), Y. Yang (1), R. Covington (1), T. Durig (1)
(1) Ashland, U.S.A.

View Abstract

321 The Impact of HPMC and MC Substitution on Crystallization Inhibition for Different Drugs
Presenter: Bi, Vivian. Authors: V. BI (1), Y. Yang (1), T. Durig (1)
(1) Ashland, U.S.A.

View Abstract

322 Comparative studies on a novel testing method for the determination of disintegration time of orodispersible films.
Presenter: Pham, Thu. Authors: T. PHAM (1), D. Terry (2), D. Lowry (1), D. Kirby (1)
(1) Aston University, United Kingdom; (2) Birmingham Children Hospital, United Kingdom

View Abstract

323 Sucrose Ester-Based gel as Carrier for Oral Delivery of Insulin
Presenter: Harloff-Helleberg, Stine. Authors: S. HARLOFF-HELLEBERG (1), L. Fliervoet (2), H. Nielsen (1)
(1) Section for Biologics, Dpt. of Pharmacy, University of Copenhagen, Denmark; (2) Dept. of Pharmaceutical Sci., Utrecht University, 3584 CG Utrecht, The Netherlands, Netherlands

View Abstract

324 PVA in Compressed Sustained Release Dosage Forms for the Prevention of Dose Dumping Effects
Presenter: Moddelmog, Guenter. Authors: G. MODDELMOG (1), G. Birk (1), T. Wedel (1), D. Lubda (1)
(1) MilliporeSigma, Germany

View Abstract

325 Influence of Polymeric Additives on API-loaded Silica Microparticle Dissolution
Presenter: Moddelmog, Guenter. Authors: G. MODDELMOG (1), V. Witt (1), A. Wieber (1), D. Lubda (1)
(1) MilliporeSigma, Germany

View Abstract

327 ROS-scavenging Nanoparticle Increases Chemotherapeutic Effect with Reducing Gastrointestinal Toxicity of Conventional Drugs
Presenter: Vong, Binh Long. Authors: B. VONG (1), T. Yoshitomi (1), H. Matsui (1)
(1) University of Tsukuba, Japan

View Abstract | View Presentation

328 Development of a multiparticulate system for colonic delivery of a model protein Bovine Serum Albumin (BSA)
Presenter: Jiang, Bowen. Authors: B. JIANG (1), L. Shi (1), H. Feng (1), S. Hoag (1)
(1) University of Maryland Baltimore, U.S.A.

View Abstract

329 Rheology assessment of viscoelastic changes in porcine jejunal mucus induced by nanoparticles
Presenter: Brayden, David. Authors: S. BHATTACHARJEE (1), S. Harrison (1), E. Mahon (1), S. Carrington (1), D. Brayden (1)
(1) University College Dublin (UCD), Ireland

View Abstract

330 Development, Characterization, and In Vitro Evaluation of Phospholipid Complex of Erlotinib
Presenter: Parkash, Chander. Authors: C. PARKASH (1), V. Kushwah (1), S. Suresh (1), S. Jain (1)
(1) National Institute of Pharmaceutical Education and Research (NIPER), India

View Abstract

331 Controlled Release of Lansoprazole from the Pellets Prepared with Extrusion/Spheronization
Presenter: Chen, Ko Chiang. Authors: K. CHEN (1), Y. Lee (2), C. Yang (2), P. Kuo (2)
(1) Department of Pharmaceuticals, Medical and Pharmaceutical Industry Technology and Development Center, Taiwan; (2) Medical and Pharmaceutical Industry Technology and Development Center, Taiwan

View Abstract

332 Development of injection-molded capsular devices for pulsatile and colonic delivery through the application of fused deposition modeling (FDM) 3D printing
Presenter: Melocchi, Alice. Authors: A. MELOCCHI (1), F. Parietti (2), A. Maroni (1), F. Casati (1), S. Moutaharrik (1), A. Gazzaniga (1), L. Zema (1)
(1) Università degli studi di Milano, Italy; (2) Massachusetts Institute of Technology, U.S.A.

View Abstract

333 Monoacyl phosphatidylcholine inhibits the formation of lipid multibilayer structures during in vitro lipolysis of self-emulsifying drug delivery systems
Presenter: Tran, Thuy. Authors: T. TRAN (1), S. Siqueira (1), H. Amenitsch (2), T. Rades (1), A. Müllertz (1)
(1) University of Copenhagen, Denmark; (2) Graz University of Technology, Austria

View Abstract

334 New Approaches on SNEDDS Dosing Regimens: In Vitro and In Vivo Evaluations
Presenter: Siqueira, Scheyla. Authors: S. SIQUEIRA (1), T. Rades (1), K. Graeser (2), H. Mu (1), A. Mullertz (1)
(1) University of Copenhagen, Denmark; (2) Roche, Switzerland

View Abstract | View Presentation

335 Microfluidics based liposomal co-encapsulation of drugs of divergent solubility
Presenter: Joshi, Sameer. Authors: S. JOSHI (1), D. Kirby (1)
(1) Aston University, England

View Abstract

336 Nanoporous Magnesium Carbonate - as Phase Stabilizer of Amorphous Ibuprofen
Presenter: Zhang, Peng. Authors: P. ZHANG (1)
(1) Uppsala University, Sweden

View Abstract

337 Modulated dissolution rate of fluconazole from solid dispersions produced by hot melting extrusion
Presenter: Malaquias, Lorena. Authors: L. MALAQUIAS (1), A. Teixeira (1), G. Gelfuso (1), L. Sá-Barreto (1), M. Cunha-Filho (1)
(1) University of Brasília, Brazil

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338 Effects of Hygroscopicity and Temperature on Packaging of Controlled Porosity Osmotic Pump Tablets
Presenter: Cho, Cheol-Hee. Authors: C. CHO (1), S. Kim (1), K. Hwang (1), J. Min (1), J. Seo (1), K. Hwang (1), T. Nguyen (1), S. Seok (1), E. Park (1)
(1) School of Pharmacy, Sungkyunkwan University, South Korea

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339 Miniaturized Method for Development of Ternary Solid Dispersion (TSD) Systems Containing Carvedilol
Presenter: Hwang, Kyu-Min. Authors: K. HWANG (1), J. Seo (1), S. Kim (1), K. Hwang (1), S. Seok (1), J. Min (1), C. Cho (1), T. Nguyen (1), E. Park (1)
(1) School of Pharmacy, Sungkyunkwan University, South Korea

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340 Novel strategy to improve the absorption of curcumin: Direct contact of amorphous solid nanoparticles with the cell surface enhances the transepitherial permeation of curcumin
Presenter: Kimura, Shunsuke. Authors: S. KIMURA (1), S. Kasatani (2), M. Tanaka (2), T. Shintani (2), K. Araki (3), M. Enomura (3), K. Moriyama (4), D. Inoue (4), T. Furubayashi (4), K. Kusamori (2), H. Katsumi (2), T. Sakane (2), A. Yamamoto (2)
(1) Doshisha Women's College of Liberal Arts, Japan; (2) Kyoto Pharmaceutical University, Japan; (3) M TECHNIQUE Co., Ltd., Japan; (4) Shujitsu University, Japan

View Abstract

341 Micellar system for Tamoxifen Delivery: Influence on Pharmacokinetics and Antitumor Efficacy
Presenter: Jena, Sunil. Authors: S. JENA (1), S. Samal (1), M. Chand (1)
(1) National Institute of Pharmaceutical Education and Research, India

View Abstract

342 Influence of Different Additives to Enhance Mouthfeel on Disintegration Time in FCC ODTs
Presenter: Wagner-Hattler, Leonie. Authors: L. WAGNER-HATTLER (1), C. Diaz Quijano (2), L. de Miguel (2), J. Schoelkopf (2), J. Huwyler (1), M. Puchkov (1)
(1) Department of Pharmaceutical Sciences University of Basel, Switzerland; (2) Omya International AG, Switzerland

View Abstract

343 Characterisation of human salivary parameters relevant to drug dissolution before and after administration of an orally disintegrating tablet
Presenter: Gittings, Sally. Authors: S. GITTINGS (1), P. Gershkovich (1)
(1) University of Nottingham, United Kingdom

View Abstract

344 Phosphatidylcholine-based Solid Dispersion Systems of Celecoxib
Presenter: Kim, Hyeongmin. Authors: H. KIM (1), J. Lee (1)
(1) Chung-Ang University, Korea

View Abstract

345 Oral absorption of apomorphine and its diesters using lipid based drug delivery systems
Presenter: Borkar, Nrupa. Authors: N. BORKAR (1), R. Holm (2), A. Müllertz (1), M. Yang (1), H. Mu (1)
(1) University of Copenhagen, Denmark; (2) H. Lundbeck A/S, Denmark

View Abstract

346 Bioavailability and Toxicity  of Novel Oral Delivery System for Amphotericin B loaded to PEGylated Polylactic-Polyglycolic Nanoparticles in Rats
Presenter: Radwan, Mahasen. Authors: M. RADWAN (1), B. ALQuadeib (2), L. Siller (3), B. Horrocks (3), M. Wright (3)
(1) Princess Nourah Bint Abdelrahman University, Saudi Arabia; (2) Department of Pharmaceutics, College of Pharmacy, King Saud University, Saudi Arabia; (3) Newcastle University, United Kingdom

View Abstract

347 Mannosylated Oral Amphotericin B Nanoparticles for Macrophage Targeting: In Vitro and Cell Uptake Studies
Presenter: Vaghela, Rudra. Authors: R. VAGHELA (1), K. P. K (2)
(1) JSS University, India; (2) JSS Univesrity, India

View Abstract

348 Release and Availability for Absorption of Prednisone Delayed Release Formulations during Transit through TNO Dynamic Gastrointestinal Models (TIM Systems)
Presenter: Gupta, Pranav. Authors: P. GUPTA (1), S. Bellmann (2), A. Maathuis (2), F. Kesisoglou (1)
(1) Merck and Co.,, U.S.A.; (2) TNO Triskelion, Netherlands

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349 Study of Dose-Weight Proportionality in Extended Release Multiparticulate Systems
Presenter: Rane, Manish. Authors: M. RANE (1), A. RAJABI-SIAHBOOMI (1), R. MEHTA (1)
(1) COLORCON INC., U.S.A.

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350 Surface-Dependent Mechanism for Transcellular Permeation of Polymeric Nanoparticles Across Intestinal Monolayers
Presenter: Tatham, Lee. Authors: L. TATHAM (1), J. Ford (1), H. Rogers (1), S. Rannard (1), A. Owen (1)
(1) University of Liverpool, United Kingdom

View Abstract

351 A pH-stat method to measure the dissolution rate of nano and micro-particle suspensions
Presenter: Mole, Jon. Authors: J. MOLE (1), M. Junke (2), B. Riebesehl (2), B. van Eerdenbrugh (2), A. Grandeury (2), K. Box (3), R. Taylor (3)
(1) Sirius Analytical Inc., U.S.A.; (2) Novartis Pharma AG, Switzerland; (3) Sirius Analytical, United Kingdom

View Abstract

352 Impact of Pore Forming Agents & Coating Process Conditions on Drug Release from Pellets Coated with Ethylcellulose Sustained Release Coatings
Presenter: Karan, Kapish. Authors: K. KARAN (1), S. Porter (1), B. Beissner (1)
(1) Ashland Specialty Ingredients, U.S.A.

View Abstract

353 Application of microcalorimetry as a tool to quantify adsorption of peptides on the solid surface of functionalized calcium carbonate
Presenter: Roth, Roger. Authors: R. ROTH (1), G. Quebatte (1), J. Schoelkopf (2), J. Huwyler (1), M. Puchkov (1)
(1) University of Basel, Switzerland; (2) Omya International AG, Switzerland

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354 Choosing the right development path for newly developed molecules (or choosing the right path for “older” molecules when plan A has failed to deliver)
Presenter: Plassat, Vincent. Authors: S. TINDAL (1)
(1) Catalent, U.S.A.

View Abstract

355 Development of a 24-hour Naproxen Sodium Extended Release Tablet
Presenter: Sirihorachai, Rachan. Authors: R. SIRIHORACHAI (1), P. Rosar (1), A. He (1)
(1) Bayer HealthCare LLC, U.S.A.

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356 Supersaturated controlled release matrix for delivery of BCS Class-II compound Glipizide
Presenter: Lu, Zheng. Authors: Z. LU (1), Y. Yang (2), R. Covington (2), V. Bi (2), T. Durig (2), M. Ilies (1), R. Fassihi (1)
(1) Temple University School of Pharmacy, U.S.A.; (2) Ashland Specialty Ingredients, U.S.A.

View Abstract

357 An Investigation into Critical Process Parameters of Ethylcellulose Coating of Extended Release Metoprolol Tartrate Multiparticulates
Presenter: Rajabi-Siahboomi, Ali. Authors: R. MEHTA (1), C. Cunningham (1), C. Schoener (2), A. Rajabi-Siahboomi (1)
(1) Colorcon Inc, U.S.A.; (2) The Dow Chemical Company, U.S.A.

View Abstract

358 Modeling In Vitro Release of Diclofenac Enteric Coated Tablets
Presenter: Mullin, James. Authors: J. MULLIN (1), V. Lukacova (1)
(1) Simulations Plus, U.S.A.

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359 Modeling In Vitro Release of Propranolol Matrix Tablets with Binary Polymer Mixtures
Presenter: Mullin, James. Authors: J. MULLIN (1), V. Lukacova (2)
(1) Simulations Plus, U.S.A.; (2) Simulations Plus, Inc., U.S.A.

View Abstract

360 FcBP-modified Nanoparticles Transport across the Intestinal Epithelium
Presenter: Yu, Miaorong. Authors: M. YU (1), Y. Yang (1), D. Xia (1), C. Zhu (1), S. Guo (1), Y. Gan (1)
(1) Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

View Abstract

361 Development and characterization of Nintedanib loaded PLGA nanoparticles for improved efficacy against pulmonary fibrosis
Presenter: Gupta, Vivek. Authors: B. VAIDYA (1), M. Huen (2), V. Gupta (1)
(1) Keck Graduate Institute, U.S.A.; (2) Keck Sciences Department of Claremont McKenna, Pitzer, and Scripps Colleges, U.S.A.

View Abstract

362 In vitro - in silico approach to access the potential of alcohol-induced dose dumping: Ibuprofen case
Presenter: Parojcic, Jelena. Authors: J. PAROJCIC (1), S. Cvijic (1), A. Lipovac (1), M. Lukic (1), S. Beloica (1), I. Aleksic (1)
(1) University of Belgrade - Faculty of Pharmacy, Serbia

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363 Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API
Presenter: Deshmukh, Ketkee. Authors: K. DESHMUKH (1), C. Kapadia (1), A. Shrivastava (1), G. Khanvilkar (1), P. Vaingankar (2), P. Amin (2)
(1) Gattefosse India Pvt. Ltd., India; (2) Institute of Chemical Technology, India

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364 DHP107, the first-generation oral paclitaxel delivery system
Presenter: Lee, In-Hyun. Authors: I. LEE (1), M. Son (1), H. Park (1), S. Kim (1), Y. Park (1), H. Lee (1)
(1) Dae Hwa Pharm. Co., South Korea

View Abstract

365 Development and Optimization of PLGA Nanoparticles as a Carrier System for Oral Delivery of Gemcitabine to Treat Breast Cancer
Presenter: Chen, Guanyu. Authors: G. CHEN (1)
(1) School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand

View Abstract | View Presentation

366 Preparation and Evaluation of Dextromethorphan Containing Thin Films
Presenter: Le, Anh-Dung. Authors: A. LE (1), C. Clise (1), A. Padilla (1), J. McConville (1)
(1) University of New Mexico, U.S.A.

View Abstract

367 A plug-and-play approach to receptor mediated peroral drug delivery aided by precision polymers
Presenter: Saini, Prabhjot. Authors: P. SAINI (1), R. Ganugula (1), M. Arora (1), M. Ravi Kumar (1)
(1) Texas A&M Health Science Center, U.S.A.

View Abstract

368 Surface tunable PLGA nanosystems for improving receptor mediated peroral drug delivery
Presenter: Arora, Meenakshi. Authors: M. ARORA (1), R. Ganugula (1), P. Saini (1), M. Kumar (1)
(1) Texas A&M Health Science Center, U.S.A.

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369 Characterization of “pregnant liposomes” containing nanocrystallised drug using X-ray scattering in suspension
Presenter: Li, Tang. Authors: T. LI (1), T. Rades (2), D. Cipolla (3), A. Hawley (4), B. Boyd (1)
(1) Monash Institute of Pharmaceutical Sciences, Australia; (2) University of Copenhagen, Denmark; (3) Aradigm Corporation, U.S.A.; (4) Australian Synchrotron, Australia

View Abstract

370 Enhancement of Tableting Properties of a Poorly Compressible, High-dose Drug by Melt Granulation: An Application of QbD Approach
Presenter: Vaingankar, Pradnya. Authors: P. VAINGANKAR (1)
(1) Institute of Chemical Technology, India

View Abstract

371 Novel Pegylated lipid excipients: Role in augmenting dissolution of a poorly soluble drug
Presenter: Kapadia, Chhanda. Authors: C. KAPADIA (1), M. Venkataraman (2), M. Marwah (2), M. Nagarsenker (2), N. Farah (3)
(1) Gattefosse India Pvt Ltd, India; (2) Bombay College of Pharmacy, India; (3) Gattefosse SAS, France

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372 New Approach for Determining Increase in Dissolution of Co-crystal by In Vitro Release
Presenter: Mudigonda, Koteshwara. Authors: K. MUDIGONDA (1), A. Reddy (1), S. Lekkala (1), K. Kurapati (1), D. Dogiparti (1), P. Chitturi (1), R. Nirogi (1)
(1) Suven Life Sciences Limited, India

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373 Solid Oral Dosage Formulation Development of High Potent Drugs in Early Clinical Trials
Presenter: Kurapati, Kishore. Authors: K. KURAPATI (1), D. Dogiparti (1), P. Chitturi (1), N. Nakka (1), S. Subhani (1), V. Kamadhar (1), K. Mudigonda (1), R. Nirogi (1)
(1) Suven Life Sciences Limited, India

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374 OptiGel™ Bio, Lipid based formulations for macromolecules oral delivery: a case study
Presenter: Plassat, Vincent. Authors: V. PLASSAT (1)
(1) Catalent Pharma Solutions, France

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375 Fast track development applied to softgel formulation using quality by design (QbD)
Presenter: Plassat, Vincent. Authors: V. PLASSAT (1), S. de Paiva Lacerda (1), B. Hilbold (1)
(1) Catalent Pharma Solutions, France

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376 Liposomal Doxorubicin for bile acid transporters-mediated oral absorption
Presenter: Hwang, Hee Sook. Authors: H. HWANG (1), C. Lee (2), K. Na (2), Y. Bae (1)
(1) University of Utah, U.S.A.; (2) The Catholic University of Korea, Korea

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377 Tablet Dosage Form of Oxytocin for Needle-free, Sublingual Administration to Prevent Postpartum Hemorrhage
Presenter: Lal, Manjari. Authors: M. LAL (1)
(1) PATH, U.S.A.

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378 Controlled suspensions as a method for small scale dissolution of poorly water-soluble compounds
Presenter: Andersson, Sara. Authors: S. ANDERSSON (1), C. Bergström (1)
(1) Uppsala University, Sweden

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379 Developing a Stable Aqueous Enteric Coating Formulation with Hydroxypropyl Methylcellulose Acetate Succinate
Presenter: Deshpande, Tanvi. Authors: T. DESHPANDE (1), A. Quadir (2), S. Obara (2), S. Hoag (1)
(1) University of Maryland, Baltimore, U.S.A.; (2) SE Tylose USA, Inc., U.S.A.

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380 Compositional and Performance Stability of a Fully Formulated Ethylcellulose Barrier Membrane Coating System
Presenter: Rajabi-Siahboomi, Ali. Authors: A. RAJABI-SIAHBOOMI (1), L. Martin (1), J. Teckoe (1)
(1) Colorcon, U.S.A.

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381 The Development of Orally Disintegrating Tablets Incorporating Biologically Active Excipients
Presenter: Pollard, John. Authors: J. POLLARD (1), A. Rajabi-Siahboomi (2), R. Badhan (1), A. Mohammed (1), Y. Perrie (1)
(1) Aston University, United Kingdom; (2) Colorcon, U.S.A.

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382 Effect of Formulation and Physiological Parameters on Oral Drug Absorption from SEDDS by Design of Experiments Approach
Presenter: Chavan, Neha. Authors: N. CHAVAN (1), F. Barile (1)
(1) St. John's University, U.S.A.

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383 Application of Fused Deposition Modeling (FDM) 3D printing in the fabrication of pharmaceutical oral solid dispersions for the delivery of poorly soluble drugs
Presenter: Qi, Sheng. Authors: S. QI (1), M. Alhijjaj (1), P. Belton (1)
(1) University of East Anglia, United Kingdom

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384 Development of a gastro-resistant (GR) formulation of a weak basic drug and evaluation of its pharmacokinetic (PK) impact
Presenter: Barrocas, Pedro. Authors: P. BARROCAS (1), T. Vasconcelos (1), H. Almeida (1), S. Bastos (1), A. Loureiro (1), R. Lima (1), P. Soares-da-Silva (1)
(1) BIAL - Portela & Cª., S.A., Portugal

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385 PBPK modelling applied to a weak basic drug formulated as a gastro-resistant (GR) tablet
Presenter: Vasconcelos, Teofilo. Authors: T. VASCONCELOS (1), P. Barrocas (1), H. Almeida (2), S. Bastos (1), P. Soares-da-Silva (1), R. Lima (1)
(1) BIAL - Portela & Ca, S.A., Portugal; (2) BIAL - Portela & Ca, S.A, Portugal

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386 Effect of poloxamer grade in the water solubility of resveratrol solid dispersions
Presenter: Vasconcelos, Teofilo. Authors: S. Marques (1), B. Sarmento (2), T. Vasconcelos (3)
(1) CIBIO/InBIO-UP, Portugal; (2) INEB/ I3S/ CESPU, Portugal; (3) BIAL / INEB, Portugal

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387 Binary and Ternary Griseofulvin Solid Dispersion for Solubility Enhancement and Controlled Release
Presenter: Lu, Jiannan. Authors: J. LU (1), S. Obara (1), S. Kikuchi (2)
(1) Shin-Etsu Chemical, U.S.A.; (2) Shin-Etsu Chemical, Japan

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388 Design and characterization of mixed micelles to improve oral drug bioavailability
Presenter: Veiga, Francisco. Authors: C. AMARAL (1), C. Cabral (1), F. Veiga (1), A. Figueiras (1)
(1) Faculty of Pharmacy of University of Coimbra, Portugal

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389 Application study of fine-particle methylcellulose as dry binder for tablets
Presenter: Obara, Sakae. Authors: S. OBARA (1), T. Yokosawa (1), S. Kikuchi (1), N. Maruyama (1)
(1) Shin-Etsu Chemical Co., Ltd., Japan

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390 Aqueous Enteric Coating Using Hypromellose Phthalate
Presenter: Cha, Jaeuk. Authors: J. CHA (1), J. Son (1), S. Lee (1)
(1) Samsung Fine Chemicals, Korea

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391 Combining Lipophilic Prodrugs and Lipid Based Nanomedicine to Convert Injectable to Oral Chemotherapy
Presenter: Prestidge, Clive. Authors: C. PRESTIDGE (1)
(1) University of South Australia, Australia

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392 Evaluation of EUDRAGIT® NM 30 D as a Binder in Drug Layering on Pellets
Presenter: Asgarzadeh, Firouz. Authors: J. AMRUTKAR (1), S. JOSHI (1), S. DOKE (1)
(1) EVONIK INDIA PRIVATE LIMITED, India

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393 Effect of Nanoparticle Size, Shape and Surface Chemistry on Oral Drug Delivery
Presenter: Banerjee, Amrita. Authors: A. BANERJEE (1), J. Q1 (1), R. Gogoi (1), J. Wong (1), S. Mitragotri (1)
(1) University of California Santa Barbara, U.S.A.

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394 Folic Acid Functionalized Chitosan Nanoparticles for Improved Insulin Enzymatic Stability and Intestinal Permeation
Presenter: Mohamed Abdel-Bar, Hend. Authors: H. MOHAMED ABDEL-BAR (1), E. Sadder El-Leithy (2), R. Abd el-Moneum (2)
(1) National Organization of Drug Control and Research, Egypt; (2) Faculty of Pharmacy, Helwan University, Egypt

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395 Preparation and evaluation of pharmaceutical cocrystal of poorly soluble flavonoid components
Presenter: Xie, Yan. Authors: Y. XIE (1), M. Liu (1), M. Xia (1)
(1) Shanghai University of Traditional Chinese Medicine, China

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641 Developing Analytical Methods for In Vitro Comparative Nasogastric (NG) Tube Studies of Esomeprazole Magnesium Delayed Release Capsules
Presenter: Guo, Changning. Authors: C. GUO (1), A. Hoover (1), D. Sun (1), H. Wen (1), W. Jiang (1), M. Cui (1), D. Keire (1)
(1) US FDA, U.S.A.

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650 Mechanistic Studies of Drug-HPMCAS interactions: Precipitation inhibition of supersaturated rapid crystallizing drug in FaSSIFCapsules
Presenter: Tewari, Divya. Authors: D. Tewari (1), T. Durig (1), K. Bhandari (1)
(1) Ashland Speciality Ingredients, U.S.A.

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collapse Overcoming Biological Barriers in Drug Delivery

18 Mechanisms for Improving Drug Delivery in Pancreatic Cancer
Presenter: Korc, Murray. Authors: M. KORC (1)
(1) Indiana University School of Medicine, U.S.A.

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19 Bio-inspired Materials and Carriers for Small RNA Delivery
Presenter: Raemdonck, Koen. Authors: K. RAEMDONCK (1), S. Stremersch (1), L. Wayteck (1), L. De Backer (1), K. Braeckmans (1), S. De Smedt (1)
(1) Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, 9000 Ghent, Belgium

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396 A pH-responsive cell-penetrating peptide-modified liposomes for enhanced therapy of integrin αvβ3-positive melanoma
Presenter: Shi, Kairong. Authors: K. SHI (1), J. Li (1), Y. Qiu (1), H. Gao (1), Q. He (1)
(1) West China School of Pharmacy, Sichuan University, China

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397 A brain-specific delivery strategy targeting to a novel organic cation transporter: pyrilamine-sensitive H+/OC antiporter
Presenter: Wang, Xinyi. Authors: X. WANG (1), Z. Zhang (1)
(1) West China School of Pharmacy, Sichuan University, China

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398 Integrated analysis on effect of molecular weight of polymer coating and conjugating site of targeted ligand on oral protein nano-therapeutics
Presenter: Liu, Min. Authors: M. LIU (1), Y. Huang (1)
(1) West China School of Pharmacy, Sichuan University, China

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399 Microbubble-Enhanced Ultrasound for Non-viral Gene Delivery to the Brain
Presenter: Tan, James-Kevin. Authors: J. TAN (1), B. Pham (1), Y. Zong (1), C. Perez (1), T. Matula (1), P. Mourad (1), H. Wei (2), D. Sellers (1), P. Horner (3)
(1) University of Washington, U.S.A.; (2) Lanzhou University, China; (3) Houston Methodist Research Institute, U.S.A.

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400 Transformable Liquid Crystals for Efficient Cytosolic Delivery of siRNA
Presenter: Zhang, Xinxin. Authors: X. ZHANG (1), S. He (1), C. Zhu (1), Y. Gan (1)
(1) Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

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401 Functionalized Cellulose Derivatives for Enhanced Nasal Drug Delivery
Presenter: Katz, Joshua. Authors: J. KATZ (1), S. Jordan (1), R. Jemison (1), J. Curtis-Fisk (1)
(1) The Dow Chemical Company, U.S.A.

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402 Geometry optimized t-micelles: a trojan horse for enhanced brain delivery
Presenter: Desai, Preshita. Authors: P. DESAI (1), V. Patravale (1)
(1) Institute of Chemical Technology, India

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403 Engineering leukocyte mimetic nanoparticles for enhancing extravasation at peritumoral endothelium
Presenter: Xu, Jun. Authors: J. XU (1)
(1) Purdue University, U.S.A.

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404 A facile approach to functionalize cell membrane-coated nanoparticles
Presenter: Zhou, Hao. Authors: H. ZHOU (1)
(1) Drexel University, U.S.A.

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407 Polymer Architecture and Chain Length Influence Macrophage Response to Micelles
Presenter: Gemeinhart, Richard. Authors: J. RAYAHIN (1), R. Pearson (1), H. Hsu (1), J. Bugno (1), S. Hong (1), R. Gemeinhart (1)
(1) University of Illinois, U.S.A.

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408 Cellular uptake of antibody via cross-linker induced endocytosis
Presenter: Sasaki, Koichi. Authors: K. SASAKI (1), D. Funamoto (1), A. Kishimura (1), T. Mori (1), Y. Katayama (1)
(1) Graduate school of Engineering, Kyushu University, Japan

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409 Stimuli-Regulated Endosomal Escape and Gene Release for High Gene Transfection
Presenter: Kim, Jinhwan. Authors: J. KIM (1), I. Kwon (2), W. Kim (1)
(1) POSTECH, Korea; (2) Kyung Hee University, Korea

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410 Preparation and Evaluation of Dry Powder Inhaler Containing Sildenafil
Presenter: Cho, Cheol-Hee. Authors: C. CHO (1), K. Hwang (1), S. Kim (1), S. Seok (1), J. Seo (1), K. Hwang (1), J. Min (1), T. Nguyen (1), E. Park (1)
(1) School of Pharmacy, Sungkyunkwan University, South Korea

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411 Di-block and tri-block polylactide-based nano-drug delivery for 5-fluorouracil with enhanced anticancer activity
Presenter: Yassin, Alaa Eldeen. Authors: A. YASSIN (1), A. Ashour (2), M. Badran (2), A. Kumar (3), A. Rishi (4)
(1) College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; (2) College of Pharmacy, King Saud University, Saudi Arabia; (3) Vitiligo Research Chair, College of Medicine, King Saud University, Saudi Arabia; (4) Departmen

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412 Circulating monocyte subsets in vascular injury following liposomal bisphosphonate treatment
Presenter: Golomb, Gershon. Authors: G. GOLOMB (1), E. Grad (1), K. Zolotarevsky (1), D. Gutman (1)
(1) The Hebrew University of Jerusalem, Israel

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413 Convection Enhanced Delivery of Temozolomide Liposomes
Presenter: Golomb, Gershon. Authors: G. GOLOMB (1), M. Nordling-David (1), D. Guez (2), R. Yaffe (1), Y. Mardor (2)
(1) The Hebrew University of Jerusalem, Israel; (2) Sheba Medical Center, Israel

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414 Bio-inspired pseudo-peptides for enhancement of cell internalization and development of a multifunctional liposomal delivery platform
Presenter: Chen, Siyuan. Authors: S. CHEN (1), R. Chen (1)
(1) Imperial College London, United Kingdom

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415 Smart Design of Antibody Therapeutics for Treatment of Rheumatoid Arthritis
Presenter: Hahn, Sei Kwang. Authors: S. HAHN (1), H. Lee (1)
(1) POSTECH, Korea

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416 What Does RGD Do in Tumour-targeted Drug Delivery?
Presenter: Wu, Zimei. Authors: Z. WU (1), E. Kang (1), D. Svirskis (1)
(1) School of Pharmacy, University of Auckland, New Zealand

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417 Membrane interactions of lipidated cell-penetrating peptides depend on lipidation site and degree
Presenter: Hedegaard, Sofie. Authors: S. HEDEGAARD (1), M. Cárdenas (2), L. Jorgensen (1), H. Mørck Nielsen (1)
(1) University of Copenhagen, Faculty of Health and Medical Sciences, Denmark; (2) Malmo University, Faculty of Health and Society, Sweden

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419 Physicochemical properties of orally inhaled drugs at 37 °C in Simulated Lung Fluid
Presenter: Mole, Jon. Authors: J. MOLE (1), K. Box (2), J. Comer (2), R. Ruiz (2), A. Llinàs (3)
(1) Sirius Analytical Inc., U.S.A.; (2) Sirius Analytical, United Kingdom; (3) AstraZeneca, Sweden

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420 Ultrasound actuated co-delivery of doxorubicin and verapamil to overcome multi-drug resistance
Presenter: Williams, Jacob. Authors: J. WILLIAMS (1), W. Pitt (1)
(1) Brigham Young University, U.S.A.

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421 Surface modification of nanoparticle with human serum albumin
Presenter: Hyun, Hyesun. Authors: H. HYUN (1)
(1) Purdue University, U.S.A.

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422 Particle Engineering for Intracellular Delivery of Vancomycin
Presenter: Pei, Yihua. Authors: Y. PEI (1)
(1) Purdue University, U.S.A.

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423 The enhancement of electroporation by pretreatment of cell penetrating peptides (CPPs)
Presenter: Kang, Seongsu. Authors: Y. Kim (1), H. Park (2), S. Kang (3)
(1) Korea Advanced Institute Science and Technology (KAIST), South Korea; (2) Chung-Ang University, South Korea; (3) Korea Advanced Institute of Science and Technology (KAIST), South Korea

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424 Ultrasound triggered liposomes for the delivery of radiopharmacueticals
Presenter: Menon, Jyothi. Authors: J. Owen (1), S. Bian (1), E. Stride (1), K. Vallis (1), R. Carlisle (1), J. Menon (1)
(1) University of Oxford, United Kingdom

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425 Chitosan-coated Pluronic F127-TPGS Mixed Micelles for the Co-delivery of siRNA and Doxorubicin
Presenter: Mohd Amin, Mohd Cairul Iqbal. Authors: M. MOHD AMIN (1), A. Butt (1), H. KATAS (1)
(1) UNIVERSITI KEBANGSAAN MALAYSIA, Malaysia

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426 A Biostable Tumor Microenvironment-Recognizing Nanoparticle Based on Sequentially Activatable PEI Derivatives
Presenter: Ko, Hyewon. Authors: H. KO (1), J. Jeon (1), J. Park (1)
(1) Sungkyunkwan University, South Korea

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427 Cytotoxicity assessment and intestinal electrogenic ion transport changes induced by DL-Selenomethionine.
Presenter: Mc Kinley, Ciara. Authors: C. MC KINLEY (1), S. Ryan (1), D. Brayden (1)
(1) University College Dublin, Ireland

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428 Endocytic trafficking and intracellular release of cargos from mesoporous silica nanocarriers in cancer cells
Presenter: Desai, Diti. Authors: D. DESAI (1), J. Zhang (2), N. Prabhakar (1), T. Näreoja (3)
(1) Åbo Akademi University, Finland; (2) Chongqing University, China; (3) University of Turku, Finland

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429 High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines using Prodrugs
Presenter: Rautiola, Davin. Authors: D. RAUTIOLA (1), M. Kapoor (1), N. Cheryala (1), G. Georg (1), J. Cloyd (1), R. Siegel (1)
(1) University of Minnesota, U.S.A.

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430 Non-specific Binding and Steric Hindrance Thresholds for Penetration of Nanoparticles in Tumor Tissue
Presenter: Perez Bermudez, Jimena. Authors: J. PEREZ BERMUDEZ (1), A. Wadajkar (1), C. Schneider (1), J. Mauban (1), G. Woodworth (1), J. Winkles (1), A. Kim (1)
(1) University of Maryland Baltimore, U.S.A.

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431 Heterogeneity in Cervical Tumor Microenvironment Significantly Impacts the Delivery of a Heat-Activated Thermosensitive Liposome Formulation of Cisplatin
Presenter: Dou, Yannan Nancy. Authors: Y. DOU (1), N. Chaudary (2), M. Dunne (1), H. Huang (1), D. Jaffray (2), M. Milosevic (2), C. Allen (1)
(1) University of Toronto, Canada; (2) Princess Margaret Cancer Center, Canada

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432 In vitro Cytotoxicity of pH-sensitive Liposomes for a Hypoxia-Activated Prodrug
Presenter: Wu, Zimei. Authors: Z. WU (1), M. Yang (2), W. Wilson (3)
(1) University of Auckland, New Zealand; (2) School of Pharmacy, University of Auckland, New Zealand; (3) Auckland Cancer Society Research Centre, University of Aucklanfd, New Zealand

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433 Doxorubicin-loaded PLGA nanoparticles: influence of the drug release rate on the antitumour efficacy
Presenter: Gelperina, Svetlana. Authors: Y. MALINOVSKAYA (1), S. Gelperina (1), A. Khalansky (2), O. Maksimenko (1), E. Shipulo (1), V. Fedoseeva (2), V. Razzhivina (1), J. Kreuter (3), V. Balabanyan (1), O. Makarova (2)
(1) Drug Technology LLC, Russia; (2) Institute of Human Morphology, Russia; (3) Institute of Pharmaceutical Technology, Goethe-University, Russia

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434 Targeting the DCIR Receptor with a TLR7 Agonist Specifically Activates Monocytes and DCs
Presenter: Klauber, Thomas. Authors: T. KLAUBER (1), J. Laursen (2), R. Maj (3), S. Pedersen (2), S. Jensen (1), T. Andresen (1)
(1) Technical University of Denmark, Department of Micro- and Nanotechnology, Denmark; (2) Technical University of Denmark, Department of Systems Biology, Denmark; (3) Telormedix SA, Switzerland

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435 Overcoming Cellular Membrane Barrier and Targeting Mitochondria of Multidrug Resistant Cancer Cells by Polymer-Lipid Hybrid Nanoparticles with Synergistic Drug Combination
Presenter: Li, Lily Yi. Authors: R. ZHANG (1)
(1) Leslie Dan Faculty of Pharmacy, University of Toronto, Canada

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436 Enhanced antitumor efficiency by thermosensitive liposome with high-intensity focused ultrasound
Presenter: Lee, Minchang. Authors: M. LEE (1), D. You (1)
(1) Sungkyunkwan University, Korea

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437 Diselenide-bearing micelles for reactive oxygen species-sensitive drug delivery
Presenter: Veerasikku Gopal, Deepagan. Authors: D. VEERASIKKU GOPAL (1), D. you (1), V. Naralla (1), J. Park (1)
(1) Sungkyunkwan University, South Korea

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438 Tuning the Mechanical Stiffness of Discoidal Polymeric Nanoconstructs inhibits macrophage uptake and enhances tumor accumulation
Presenter: Palange, Anna Lisa. Authors: A. PALANGE (1), I. Rizzuti (1), M. Colasuono (1), M. Francardi (1), D. Di Mascolo (1), P. Decuzzi (1)
(1) Italian Institute of Technology, Italy

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439 Gold Nanorod-Loaded Stem Cells for Cancer Photothermal Therapy
Presenter: Chuang, Chun-Chiao. Authors: C. CHUANG (1)
(1) Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan

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440 The Effect of 100 nm PLGA-PEG NPs on Platelets: A Comparative Study in Washed Platelets and Platelet-Rich Plasma.
Presenter: Bakhaidar, Rana. Authors: R. BAKHAIDAR (1), R. Pabari (2), S. O'Neill (3), Z. Ramtoola (2)
(1) School of Pharmacy and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Ireland; (2) School of Pharmacy, Royal College of Surgeons in Ireland, Ireland; (3) Molecular and Cellular Therapeutics, Royal College of Surgeons in Ire

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441 Cellular tropism of intracranially delivered brain-penetrating nanoparticles
Presenter: Gaudin, Alice. Authors: A. GAUDIN (1)
(1) Biomedical Engineering Department, Yale University, U.S.A.

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441 Cellular tropism of intracranially delivered brain-penetrating nanoparticles
Presenter: Gaudin, Alice. Authors: A. GAUDIN (1)
(1) Biomedical Engineering Department, Yale University, U.S.A.

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442 Hydrophobized Microgels for the Delivery of Antipsychotic Drugs to the Brain
Presenter: Simpson, Madeline. Authors: M. SIMPSON (1), Y. Katare (1), S. Kooner (1), N. Smeets (1), R. Mishra (1), T. Hoare (1)
(1) McMaster University, Canada

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444 Multifunctional Polymer Nanoparticles Deliver Antibodies cross the Blood-Brain Barrier and Inhibit Brain Metastases of Breast Cancer
Presenter: Wu, Xiaoyu (Shirley). Authors: C. HE (1)
(1) University of Toronto, Canada

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445 Effect of Concentration of Drug Solution on the Diffusion Parameters of Propranolol
Presenter: Kurapati, Kishore. Authors: K. KURAPATI (1), A. Reddy (1), D. Dogiparti (1), S. Lekkala (1), P. Chitturi (1), K. Mudigonda (1), R. Nirogi (1)
(1) Suven Life Sciences Limited, India

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446 Intracellular Delivery hi-bFGF-2 via Alg-g-PEG Nanospheres for Inhibiting Tumor Growth
Presenter: Oldinski, Rachel. Authors: T. MIAO (1), J. Spees (1), R. Oldinski (1)
(1) University of Vermont, U.S.A.

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447 Cell Type Specific Targeting delivery of p38 MAPK inhibitors for Multiple Sclerosis Therapy
Presenter: Oldinski, Rachel. Authors: T. MIAO (1), A. Raza (1), D. Krementsov (1), R. Oldinski (1)
(1) University of Vermont, U.S.A.

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448 Effect of surface properties of PLGA-PEG nanovertors on BBB translocation
Presenter: Fakhari Tehrani, Soudeh. Authors: S. FAKHARI TEHRANI (1), F. Bernard (1), D. Huot (1), G. Leclair (1), P. Hildgen (1), V. Roullin (1)
(1) Université de Montréal, Canada

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450 Kolliphor® HS 15 Micelles for the Delivery of Hydrophobic Neuroprotective Agent CNB001
Presenter: Merchant, Zahra. Authors: Z. MERCHANT (1), K. Taylor (1), G. Buckton (1), S. Somavarapu (1)
(1) UNIVERSITY COLLEGE LONDON, United Kingdom

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451 Lung targeted moxifloxacin loaded vesicular delivery systems
Presenter: Osman, Rihab. Authors: R. OSMAN (1), A. Hamed (1), S. Mansour (1)
(1) Faculty of Pharmacy, Ain Shams University, Egypt

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452 Spray dried self-assembled nanocomplexes targeting the respiratory tract
Presenter: Osman, Rihab. Authors: R. OSMAN (1), D. mahmoud (1), H. abdel Bar (2), O. Sammour (1)
(1) Faculty of pharmacy, Ain Shams university, Egypt; (2) National Organization of Drug Control and Research, Giza, Egypt, Egypt

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453 PEG-Lipid based nanocarriers for the treatment of Niemann Pick Type C-1 based lysosomal storage disorder.
Presenter: Sahay, Gaurav. Authors: G. SAHAY (1), A. Brown (1), S. Patel (2)
(1) Oregon State University, U.S.A.; (2) Oregon State Univerity, U.S.A.

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454 Lung targeted montelukast loaded PLGA nano-in-microparticles for treatment of asthma
Presenter: Osman, Rihab. Authors: R. OSMAN (1), R. Abdelgawad (1), G. Awad (1), N. Mortada (1)
(1) Faculty of Pharmacy, Ain Shams University, Egypt

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455 Intracellular Trafficking and Endosomal Escape of Nanoparticles for mRNA Delivery
Presenter: Patel, Siddharth. Authors: S. PATEL (1), G. Sahay (1)
(1) Oregon State University, U.S.A.

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456 Hyperthermia-triggered release of cisplatin from thermosensitive liposomes improves local control of triple-negative breast cancer tumours
Presenter: Dunne, Michael. Authors: M. DUNNE (1), Y. Dou (1), T. Spence (1), S. Gontijo (2), C. Allen (1)
(1) University of Toronto, Canada; (2) Universidade Federal de Minas Gerais, Brazil

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457 An In-vitro Evaluation of Transferrin-Targeted Resveratrol-Loaded Liposomes for Glioblastoma Treatment
Presenter: Jhaveri, Aditi. Authors: A. JHAVERI (1)
(1) Northeastern University, U.S.A.

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459 Using combinatorial biology to develop design principles for mucus-penetrating drug delivery systems
Presenter: Ghosh, Debadyuti. Authors: D. GHOSH (1)
(1) The University of Texas at Austin, U.S.A.

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460 Lipid-like Nanoparticles for mRNA Delivery in vivo
Presenter: Dong, Yizhou. Authors: Y. DONG (1), B. Li (1), X. Luo (1), B. Deng (1), J. Wang (1), D. McComb (1), Y. Shi (2), K. Gaensler (2), X. Tan (3), A. Dunn (4), B. Kerlin (4)
(1) The Ohio State University, U.S.A.; (2) University of California-San Francisco, U.S.A.; (3) Tsinghua University, China; (4) Nationwide Children’s Hospital, U.S.A.

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461 Nanoparticles developed as siRNA carriers towards the blood-brain barrier: from targeting to safe administration
Presenter: Gomes, Maria João. Authors: M. GOMES (1), C. Fernandes (2), S. Martins (3), F. Borges (2), B. Sarmento (1)
(1) I3S - INEB, Portugal; (2) Departamento de Química, Faculdade de Ciências, Universidade do Porto, Portugal; (3) Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Denmark

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462 The dynamics of intrathecal bolus and factors of intrathecal pharmacokinetics
Presenter: Papisov, Mikhail. Authors: M. PAPISOV (1), V. Belov (1), D. Levine (2), A. Fischman (3), J. Appleton (2), B. Durcanova (2)
(1) Massachusetts General Hospital & Harvard Medical School, U.S.A.; (2) Massachusetts General Hospital, U.S.A.; (3) Shriners Hospitals for Children, U.S.A.

View Abstract

463 Liposomes and skin barrier: getting through and restoring function
Presenter: Lima, Eliana. Authors: E. LIMA (1)
(1) Universidade Federal de Goiás, Brazil

View Abstract

464 Nuclear Targeting of Quantum Dots is Governed by the Surface Density of Peptidic Targeting Residues
Presenter: Stepensky, David. Authors: D. STEPENSKY (1), A. Maity (1)
(1) Ben-Gurion University of the Negev, Israel

View Abstract

465 Surface-modified Berberine loaded chitosan nanoparticles for brain delivery: Safety and efficacy evaluation
Presenter: Nounou, Mohamed. Authors: M. NOUNOU (1)
(1) Appalachian College of Pharmacy, U.S.A.

View Abstract

466 Study of the permeability of cellular membranes using P-glycoprotein reconstituted into proteoliposomes
Presenter: Flandrin, Aurore. Authors: A. FLANDRIN (1), A. Flandrin (1)
(1) Université de Montréal, Canada

View Abstract

467 Design and development of novel nanocarriers for transcutaneous vaccination
Presenter: González Aramundiz, José Vicente. Authors: J. GONZÁLEZ A (1)
(1) Pontificia universidad Católica de Chile, Chile

View Abstract

468 The role of particle physico-chemical properties on phagocytosis
Presenter: Garapaty, Anusha. Authors: A. GARAPATY (1), J. Champion (1)
(1) Georgia Institute of Technology, U.S.A.

View Abstract

561 An Artificial Intelligence System of Oral Solution Formulations
Presenter: Ouyang, Defang. Authors: D. OUYANG (1)
(1) University of Macau, China

View Abstract
collapse Parenteral Systemic Delivery of Biopharmaceuticals: Overcoming Product Development and Regulatory Challenges

20 Transforming the State-of-the-Art for Manufacturing Biotherapeutics: Increasing quality and affordability for a global market
Presenter: Kerwin, Bruce. Authors: B. KERWIN (1)
(1) Just Biotherapeutics, U.S.A.

View Abstract

21 Challenges with High Concentration Protein Solutions: Viscosity, Delivery of Large Volumes, and Device Considerations
Presenter: Lambert, William. Authors: W. LAMBERT (1)
(1) Omeros, U.S.A.

View Abstract | View Presentation

469 Therapeutic application of a new type of nano-sized carbon monoxide donor in colitis model mice
Presenter: Nagao, Saori. Authors: S. NAGAO (1), K. Taguchi (2), H. Sakai (3), M. Otagiri (2), T. Maruyama (1)
(1) Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan; (2) Faculty of Pharmaceutical Sciences, Sojo University, Japan; (3) Department of Chemistry, Nara Medical University, Japan

View Abstract

470 Implantable Pump Actuated by Static Magnetic Field for On-demand Pulsatile Drug Delivery
Presenter: Lee, Seung Ho. Authors: S. LEE (1), Y. Choy (1)
(1) Seoul National University, South Korea

View Abstract

471 Binding of Human Serum Albumin to Liposomes Studied by Fluorescence Correlation Spectroscopy
Presenter: Kristensen, Kasper. Authors: K. KRISTENSEN (1), A. Urquhart (1), E. Thormann (2), T. Andresen (1)
(1) Department of Micro- and Nanotechnology, DTU Nanotech, Technical University of Denmark, Denmark; (2) Department of Chemistry, DTU Chemistry, Technical University of Denmark, Denmark

View Abstract | View Presentation

472 Studies on Lyophilized Liposomal Formulations of IRL-1620 and their in Vitro Evaluation Using Cell Based Assays
Presenter: Joshi, Medha. Authors: M. JOSHI (1), A. Gulati (1), N. Gwizdz (1)
(1) Midwestern University Chicago College of Pharmacy, U.S.A.

View Abstract

473 Feasibility of subcutaneous entecavir implants for chronic hepatitis B treatment
Presenter: Henry, Steven. Authors: S. HENRY (1), S. Barrett (1), S. Forster (1), R. Teller (1), Z. Yang (1), M. Gindy (1)
(1) Merck and Co., U.S.A.

View Abstract

474 Gold-crosslinked nanoparticle based on triblock copolymer as robust nanocarriers of an anticancer drug
Presenter: Jeon, Sangmin. Authors: S. JEON (1), H. Ko (1), Y. Cho (2), J. Park (1)
(1) Sungkyunkwan University, South Korea; (2) Hanyang University, South Korea

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475 Ex-Vivo Intraocular Model to Investigate Long-Term Protein stability in the Vitreous Humor
Presenter: Patel, Sulabh. Authors: S. PATEL (1), D. Jere (1), J. Stracke (1), U. Altenburger (2), H. Mahler (2)
(1) Pharmaceutical Development and Supplies PTD (Biologics Europe), F. Hoffmann-La Roche Ltd, Basel, Switzerland, Switzerland; (2) Pharmaceutical Development and Supplies PTD (Biologics Europe), F. Hoffmann-La Roche Ltd, Basel, Switzerland, Switzerland

View Abstract

476 Reformulation of Amphotericin B: The Toxicity Reducing Power of PEG-DSPE
Presenter: Alvarez, Celeste. Authors: C. ALVAREZ (1), D. Shin (1), G. Kwon (1)
(1) University of Wisconsin-Madison School of Pharmacy, U.S.A.

View Abstract

477 Intravenous albumin-based formulation of rifabutin: toxicological evaluation
Presenter: Osipova, Nadezhda. Authors: N. OSIPOVA (1), S. Gelperina (1), O. Maksimenko (1), A. Anshakova (2), O. Avdeeva (3), V. Makarov (3), M. Makarova (3)
(1) Drugs Technology LLC, Russia; (2) D.Mendeleyev University of Chemical Technology of Russia, Russia; (3) St. Petersburg Institute of Pharmacy, Russia

View Abstract | View Presentation

478 MMP-sensitive doxorubicin-loaded liposomes for enhanced anticancer activity
Presenter: Clergeaud, Gael. Authors: G. CLERGEAUD (1)
(1) Technical University of Denmark, Denmark

View Abstract

479 Manipulation of resveratrol cubosomes for improved cytotoxicity on HepG2 human hepatoma
Presenter: Abdel-Bar, Hend Mohamed. Authors: H. ABDEL-BAR (1), R. Sanad (1)
(1) National Organization of Drug Control and Research, Egypt

View Abstract

480 Effect of Polymer Source on the In Vitro Release Characteristics of In Situ Forming Implants
Presenter: Suh, Min sung. Authors: M. SUH (1), M. Kastellorizios (2), W. Qu (3), Y. Wang (3), S. Choi (3), D. Burgess (1)
(1) University of Connecticut, U.S.A.; (2) Biorasis. Inc, U.S.A.; (3) FDA, U.S.A.

View Abstract

481 Effect of Manufacturing Processes on In Vitro Performance of Peptide Microspheres
Presenter: Shen, Jie. Authors: J. SHEN (1), D. Burgess (1), W. Qu (2), Y. Wang (2), S. Choi (2)
(1) University of Connecticut, U.S.A.; (2) U.S. FDA, U.S.A.

View Abstract

482 Comparative Analysis of Polymeric Conjugates Containing First Generation Geldanamycin or Second Generation SNX-5422 as HSP90 Inhibitors
Presenter: Suarez del Pino, Jose Antonio. Authors: J. SUAREZ DEL PINO (1)
(1) University of Illinois at Chicago, U.S.A.

View Abstract

483 Liposomes Reloaded: A novel strategy for loading “unloadable” drugs into stealth liposomes
Presenter: Sur, Surojit. Authors: S. SUR (1), K. Kinzler (2), S. zhou (2), B. Vogelstein (2)
(1) Johns Hopkins Medical Institutions, baltimore, MD, U.S.A.; (2) Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, U.S.A.

View Abstract | View Presentation

484 A Novel Microfabricated Drug Delivery Platform with Pulsatile Release Kinetics
Presenter: McHugh, Kevin. Authors: K. MCHUGH (1), T. Nguyen (1), D. Yang (1), A. Linehan (1), S. Tzeng (1), A. Behrens (1), J. Lu (1), Z. Tochka (1), S. Rose (1), A. Wang (1), R. Langer (1), A. Jaklenec (1)
(1) Massachusetts Institute of Technology, U.S.A.

View Abstract

485 Biocompatible nanocomplexes for the prolonged delivery of LMWH: in-vitro and in-vivo evaluation
Presenter: Osman, Rihab. Authors: R. OSMAN (1), S. Ibrahim (1), G. Awad (1), N. Mortada (1), A. Geneidi (1)
(1) Faculty of pharmacy, Ain Shams university, Egypt

View Abstract

486 PRINT: A protein bioconjugation method with exquisite N-terminal specificity
Presenter: Sur, Surojit. Authors: Y. Qiao (1), K. Kinzler (1), B. Vogelstein (1), S. Zhou (1), S. Sur (2)
(1) Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, U.S.A.; (2) Johns Hopkins Medical Institutions, U.S.A.

View Abstract | View Presentation

488 Chemistry, Manufacturing, and Control Deficiencies in Liposomal Drug Product Submissions
Presenter: Kapoor, Mamta. Authors: M. KAPOOR (1), K. Tyner (2), S. Lee (2)
(1) US Food and Drug Administration, U.S.A.; (2) US FDA, U.S.A.

View Abstract

489 Hydrophobic prodrug nanoparticle delivery of anticancer molecularly targeted drug combinations increases plasma drug exposure and antitumor efficacy in preclinical models
Presenter: Liboiron, Barry. Authors: B. LIBOIRON (1), P. Tardi (1), S. Xie (1), L. Wan (1), W. Lui (1), L. Mayer (1)
(1) Celator Pharmaceuticals Corp., Canada

View Abstract
collapse Peptides, Proteins, and Vaccines

22 Formulating to optimize peptide chemical and physical stability
Presenter: Topp, Elizabeth. Authors: E. TOPP (1)
(1) Purdue University, U.S.A.

View Abstract | View Presentation

490 An injectable, low-toxic phospholipids-based phase separation gel inducing strong and persistent immune responses
Presenter: Han, Lu. Authors: L. HAN (1)
(1) West China School of Pharmacy, Sichuan University, China

View Abstract

491 Development of hollow encapsulin nanoparticles for the incorporation of hydrophilic compounds
Presenter: Sonotaki, Seiichi. Authors: Y. MURAKAMI (1), S. Sonotaki (1), T. Takami (1), K. Noguchi (1), M. Odaka (1), M. Yohda (1)
(1) Tokyo University of Agriculture and Technology, Japan

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492 Usefulness of Cell-Penetrating Peptides in Noninvasive Nasal Delivery of PEGylated Interferon Beta
Presenter: Kamei, Noriyasu. Authors: N. KAMEI (1), Y. Iwase (1), E. Khafagy (2), M. Miyamoto (3), M. Takeda-Morishita (1)
(1) Kobe Gakuin University, Japan; (2) Suez Canal University, Egypt; (3) Toray Industries, Inc., Japan

View Abstract

493 Selection of triple negative breast cancer cell-binding peptides using phage display
Presenter: Lee, Yun-ki. Authors: Y. LEE (1), B. Lee (1), M. Baek (2), S. Kim (3), J. Bae (4), H. Kim (5)
(1) Department of Biochemistry and Cell Biology, School of medicine, Kyungpook National University, South Korea; (2) Department of Molecular Medicine, School of medicine, Kyungpook National University, South Korea; (3) Department of Pharmacology, School o

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494 Influence of additives on Gonadorelin [6-D-Phe] release from spray-congealed lipid microparticles
Presenter: Hoffmann, Kerstin. Authors: K. HOFFMANN (1), W. Zaremba (2), J. Kauffold (3), W. Friess (1)
(1) LMU München, Germany; (2) Veyx Pharma GmbH, Germany; (3) Universität Leipzig, Germany

View Abstract

495 Affinity improvement of interleukin-4 receptor binding peptides using NeutrAvidin/biotin complexes and its effect on signaling and survival of tumor cells
Presenter: Kim, Cheong-wun. Authors: C. KIM (1), G. Padmanaban (1), M. Baek (2), S. Kim (3), H. Kim (4), J. Bae (5), B. Lee (6), H. Lee (7)
(1) Department of Biochemistry and Cell Biology, School of medicine Kyungpook National University, South Korea; (2) Department of Molecular Medicine, School of medicine, Kyungpook National University, South Korea; (3) Department of Pharmacology, School of

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496 Targeted Polymeric Micelles Bearing Anti-EphA2 Antibody Fragments Show Enhanced Cell Uptake Compared to mAbs and Fabs
Presenter: Florinas, Stelios. Authors: S. FLORINAS (1)
(1) MedImmune, U.S.A.

View Abstract

497 Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibodies
Presenter: Wang, Chao. Authors: C. WANG (1), Y. Ye (1), G. Hochu (2), Z. Gu (1)
(1) University of North Carolina at Chapel Hill, U.S.A.; (2) NCSU, U.S.A.

View Abstract

498 Optimization of M2 macrophage-targeting peptide (M2pep)
Presenter: Ngambenjawong, Chayanon. Authors: C. NGAMBENJAWONG (1), J. Pineda (1), M. Cieslewicz (1), G. Liu (1), S. Pun (1)
(1) University of Washington, U.S.A.

View Abstract

499 Protein-Loaded, Redox-Active, Injectable Gel Formed by a Polyion Complex for Local Protein Delivery
Presenter: Ishii, Shiro. Authors: S. ISHII (1), Y. Nagasaki (1)
(1) Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan

View Abstract

500 Gifting Alum with Dendritic Cell-targeting and Cellular Response-activating Abilities by Modulating its Size in a Nanoscale
Presenter: Jiang, Hao. Authors: H. JIANG (1)
(1) West China School of Pharmacy, Sichuan University, China

View Abstract

501 Rational design, synthesis, and in vitro binding study of novel peptide ligands for targeting CD13
Presenter: Uddin, Md Zahir. Authors: M. UDDIN (1), X. Li (1), H. Joo (1), J. Tsai (1), B. Jasti (1)
(1) University of the Pacific, U.S.A.

View Abstract

502 Preparation, In Vitro Characterization and In Vivo Evaluation of Polymeric Microspheres as a Sustained Release System for Anti-TNF
Presenter: Liu, Chih-Peng. Authors: F. CHENG (1), M. Lu (1)
(1) Industrial Technology Research Institute, Taiwan

View Abstract

503 Muscle wasting diseases: bioresponsive co-delivery of anti-catabolic and anabolic proteins
Presenter: Braun, Alexandra. Authors: A. BRAUN (1), M. Gutmann (1), J. Ritzer (1), R. Ebert (2), F. Jakob (2), T. Lühmann (1), L. Meinel (1)
(1) Institute for Pharmacy and Food Chemistry, University of Wuerzburg, Germany; (2) Orthopedic Center for Musculoskeletal Research, Wuerzburg, Germany

View Abstract

504 Novel in vitro study of subcutaneously administered insulin formulations
Presenter: Mole, Jon. Authors: J. MOLE (1), K. Box (2), R. Taylor (2), H. Kinnunen (3), R. Mrsny (4)
(1) Sirius Analytical Inc., U.S.A.; (2) Sirius Analytical, United Kingdom; (3) Durham University, United Kingdom; (4) University of Bath, United Kingdom

View Abstract

505 A Novel Immunotherapeutic Approach for Cancer by Foreignizing Tumor Cells Using a Polymeric Conjugate
Presenter: Shin, Jung Min. Authors: J. SHIN (1), H. Yoon (1), M. Lee (1), T. Kim (2), J. Park (1), Y. Cho (3)
(1) Sungkyunkwan University, South Korea; (2) Korea University, South Korea; (3) Hanyang University, South Korea

View Abstract

506 Effect of pH on Protein-Nanoparticle Electrostatic Interaction
Presenter: Jain, Ratnesh. Authors: R. JAIN (1), S. Dyawanapelly (1), G. Ghosh (2), P. Dandekar Jain (1)
(1) Institute of Chemical Technology, India; (2) UGC-DAE Consortium for Scientific Research, India

View Abstract

507 Multi-Parametric SPR – In vitro Characterization Method for Biopharmaceuticals and Drug Delivery systems
Presenter: Jokinen, Annika. Authors: A. JOKINEN (1), N. Granqvist (1), J. Sadowski (1)
(1) BioNavis Ltd., Finland

View Abstract

508 Chitosan-coated Polymeric NPs Loaded with a Therapeutic Peptide Prevents Asthma
Presenter: Morris, Angie. Authors: A. MORRIS (1), S. Sebag (1), I. Grumbach (1), A. Salem (1)
(1) University of Iowa, U.S.A.

View Abstract

509 Formulation and characterization of a hexagonal liquid crystalline drug delivery system
Presenter: Mun, Ellina. Authors: E. MUN (1), Y. Baez (1), Y. Lee (1), A. Otte (1), B. Soh (1), C. Song (1), K. Park (1)
(1) Purdue University, U.S.A.

View Abstract | View Presentation

510 Transnasal delivery of peptide agonist specific to neuromedin U receptor 2 to the brain for the treatment of obesity
Presenter: Tanaka, Akiko. Authors: A. TANAKA (1), Y. Takemura (1), D. Inoue (2), T. Furubayashi (2), K. Taketa (3), K. Takayama (3), Y. Hayashi (3), K. Kusamori (1), H. Katsumi (1), T. Sakane (1), A. Yamamoto (1)
(1) Kyoto Pharmaceutical University, Japan; (2) Shujitsu University, Japan; (3) Tokyo University of Pharmacy and Life Sciences, Japan

View Abstract | View Presentation

511 Microfluidics as a method for manufacturing of liposomal adjuvants
Presenter: Roces Rodriguez, Carla Belen. Authors: C. ROCES RODRIGUEZ (1), Y. Perrie (1), D. Christensen (2)
(1) Aston University, United Kingdom; (2) Statens Serum Institut, Denmark

View Abstract

512 Photothermal effects of reduced graphene oxide tethered with chimeric peptides
Presenter: Oh, Yu-Kyoung. Authors: Y. OH (1), G. Shim (1), J. Lee (1), J. Kim (1), Y. Kim (2)
(1) Seoul National University, South Korea; (2) Konkuk University, South Korea

View Abstract

513 Stimulating Pulmonary Immunity with pH-Responsive Nanoparticle Vaccines
Presenter: Knight, Frances C.. Authors: F. KNIGHT (1), J. Wilson (1), S. Sevimli (1), P. Gilchuk (1), S. Joyce (1)
(1) Vanderbilt University, U.S.A.

View Abstract

514 Self-assembling Peptide Epitopes for Tumor Vaccination
Presenter: Mastrobattista, Enrico. Authors: E. MASTROBATTISTA (1)
(1) Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht, UT, 3584 CG, Netherlands

View Abstract | View Presentation

515 Rational Design and Characterization of a Pulsatile Drug Delivery System for Single Injection Vaccination
Presenter: Behrens, Adam. Authors: A. BEHRENS (1), K. McHugh (1), C. Bishop (1), T. Nguyen (1), A. Linehan (1), Z. Tochka (1), A. Wang (1), R. Langer (1), A. Jaklenec (1)
(1) Massachusetts Institute of Technology, U.S.A.

View Abstract

516 Peptide-functionalized PAMAM Dendrimers for Targeted Delivery of DNA Vaccines to Skeletal Muscle Cells
Presenter: Jativa, Samuel. Authors: S. JATIVA (1)
(1) University of Miami, U.S.A.

View Abstract

517 Protein single-site multifunctionalization using oligonucleotide annealing.
Presenter: Kuhlmann, Matthias. Authors: M. KUHLMANN (1), A. Voldum (2), J. Schmøkel (2), G. Tsakiridou (2), E. Sohn (2), M. Thim Larsen (2), K. Howard (2)
(1) Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology, Aarhus University, Denmark; (2) Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology, Aarhus University, DK-8000 Aarhus, Denmark

View Abstract

518 A Fast and Sensitive Method for the Detection of Leuprolide Acetate: A High-Throughput Approach for the In Vitro Evaluation of Liquid Crystal Formulations
Presenter: Baez, Yahira. Authors: Y. BAEZ (1), A. Otte (1), K. Park (1)
(1) Purdue University, U.S.A.

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519 The influence of freezing in the stability and bioactivity of protein-loaded PLGA nanoparticles upon lyophilization
Presenter: Sarmento, Bruno. Authors: B. SARMENTO (1), P. Fonte (2), V. Seabra (3), M. van de Weert (4), S. Reis (2)
(1) INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Portugal; (2) UCIBIO, REQUIMTE, Department of Chemical Sciences - Applied Chemistry Lab, Faculty of Pharmacy, University of Porto, Portugal; (3) CESPU, Instituto de Investigação e Formaç

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520 Varying Peptide Valency for Optimization of PolySTAT, a Synthetic Fibrin-Crosslinking Polymer
Presenter: Lamm, Robert. Authors: R. LAMM (1), E. Lim (1), L. Chan (1), X. Wang (1), K. Weigandt (2), L. Pozzo (1), N. White (1), S. Pun (1)
(1) University of Washington, U.S.A.; (2) National Institute of Standards and Technology, U.S.A.

View Abstract

521 Improved antitumor therapies using PEGylated TNF-related apoptosis-inducing ligand in combination with established chemotherapeutics
Presenter: Lim, Sung Mook. Authors: S. LIM (1), K. Lee (1)
(1) SungKyunKwan University, Korea

View Abstract

523 Investigating The Immunomodulatory Function of Carrier-Free Vaccine Capsules
Presenter: Jewell, Christopher. Authors: Y. CHIU (1)
(1) University of Maryland - College Park, U.S.A.

View Abstract | View Presentation

524 Room temperature stabilization of live attenuated Porcine Reproductive and Respiratory Syndrome Virus vaccines by Vacuum foam drying
Presenter: Lu, Yu. Authors: Y. LU (1), F. LV (1), Z. HAO (1), Y. ZHAO (1), L. WANG (1), J. HOU (1)
(1) JAAS, China

View Abstract

525 A systemic, protease-dependent prodrug strategy for the ideal delivery of peptides
Presenter: Boettger, Roland. Authors: R. BÖTTGER (1), D. Knappe (1), R. Hoffmann (1)
(1) Universität Leipzig, Germany

View Abstract

526 Potential of Silica Encapsulated Protein for Oral Vaccine Development
Presenter: Khatri, Aparajita. Authors: A. KHATRI (1), J. Sommerville (1), S. Sharma (2), K. Finnie (1), L. Hinds (2), C. Barbe (1)
(1) Ceramisphere Pty Ltd, Australia; (2) CSIRO Biosecurity Flagship, Australia

View Abstract

527 Cry protein crystals: A novel platform for protein delivery
Presenter: Lee, Marianne M. Authors: M. LEE (1), M. Nair (2), M. Chan (1)
(1) The Chinese University of Hong Kong, Hong Kong; (2) Aaron Diamond AIDS Research Center, U.S.A.

View Abstract

528 Affinity-Based GLP-1 Release from Self-assembled Protein Microspheres
Presenter: Padmore, Trudy. Authors: T. PADMORE (1)
(1) Georgia Institute of Technology, U.S.A.

View Abstract

529 Exploring Cry protein crystals as a platform to display of tubercle antigens
Presenter: Chan, Michael. Authors: M. CHAN (1), M. Lee (1), M. Nair (2), L. Wang (1), J. Turner (3)
(1) The Chinese University of Hong Kong, Hong Kong; (2) Aaron Diamond AIDS Research Center, Rockefeller University, U.S.A.; (3) The Ohio State University, U.S.A.

View Abstract
collapse Physical Oncology: Modulating Tumor Microenvironment for Drug Delivery

23 Enhancing Blood Perfusion in Tumor Tissue by preventing Tumor associated Thrombosis using oral Heparin to improve the Distribution of Anti-cancer drugs
Presenter: Byun, Youngro. Authors: Y. BYUN (1), J. Choi (1), T. Al Hilal (1)
(1) College of Pharmacy, Seoul National University, Korea

View Abstract

530 Double-Chambered NanoCage (DCNC) Ferritin Platform:Dual-Function Payloads of Cytotoxic Peptides and Fluorescent Protein
Presenter: Yoo, Jae Do. Authors: J. YOO (1), J. Seo (1), S. Kim (1), B. Lee (1)
(1) School of Medicine, Kyungpook National University, South Korea

View Abstract

531 Bioreducible core-crosslinked micelles based on hyaluronic acid for targeted cancer therapy
Presenter: Han, Hwa Seung. Authors: H. HAN (1), K. Choi (1), J. Park (1), V. Rao (2), Y. Cho (3)
(1) Sungkyunkwan University, Korea; (2) Sungkyunkwan University, India; (3) Hanyang University, Korea

View Abstract

532 Combined administration of novel drug, NCL-240, and 2-DG in cancer cells
Presenter: Pattni, Bhushan. Authors: B. PATTNI (1), A. Jhaveri (1), A. Degterev (2), V. Torchilin (1), I. Dutta (1)
(1) Northeastern University, U.S.A.; (2) Tufts University, U.S.A.

View Abstract

533 High Intensity Focused Ultrasound Hyperthermia for Enhanced Macromolecular Delivery
Presenter: Frazier, Nick. Authors: N. FRAZIER (1), A. Payne (1), J. De Bever (1), C. Dillon (1), A. Ghandehari (1), N. Subrahmanyam (1), H. Ghandehari (1)
(1) University of Utah, U.S.A.

View Abstract | View Presentation

534 Ni(II) Arsenite-Complexed Core-Containing Polymer Nanoparticles for Cancer Therapy.
Presenter: Choi, Jeong Ryul. Authors: J. CHOI (1), H. Nam (1), H. Lee (1), S. Jeong (1), S. Lee (1)
(1) Kyung Hee University, South Korea

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535 Nitric Oxide-Releasing Hyaluronic Acid-based Nanocarrier for Intracellular Delivery
Presenter: Kim, DaEun. Authors: D. KIM (1), H. Lee (1), S. Lee (1)
(1) Kyung Hee University, South Korea

View Abstract

537 Mineralized Hybrid Nanoparticles for Nitric Oxide-Mediated Cancer Therapy
Presenter: Lee, Dae Hwan. Authors: D. LEE (1), H. Lee (2), J. Lee (2), D. Kim (2), S. Jeong (2), H. Choi (3), W. Kim (3), S. Lee (2)
(1) Kyung Hee University, South Korea; (2) Kyung Hee University, Korea; (3) POSTECH, Korea

View Abstract

538 Enhancement of EPR effect in nanomedicine with nitric oxide-releasing liposome
Presenter: Katayama, Yoshiki. Authors: Y. KATAYAMA (1), T. Yoshikawa (1), A. Kishimura (1)
(1) Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Japan

View Abstract

539 Azo-based hypoxia-sensitive amphiphilic conjugate for drug delivery
Presenter: Son, Soyoung. Authors: S. SON (1), T. Thambi (1), W. Yoo (1), J. Park (1)
(1) Sungkyunkwan University, South Korea

View Abstract

540 Designed protein therapeutics for enhancing anti-tumor immune response
Presenter: Lee, Eun Jung. Authors: E. LEE (1), G. Nam (2), N. Lee (3), I. Kim (2)
(1) Korea Institute of Science and Technology, South Korea; (2) Korea Institute of Science and Technology & Korea University, South Korea; (3) Korea Institute of Science and Technology & Seoul National University, South Korea

View Abstract | View Presentation

541 Hyperthermia-induced Triggered Release of Cisplatin from Thermosensitive Liposomes and Changes in Tumor Microenvironment in Non-Small Cell Lung Carcinoma
Presenter: Dou, Yannan Nancy. Authors: Y. DOU (1), M. Dunne (1), H. Huang (1), T. Mckee (2), D. Jaffray (2), C. Allen (1)
(1) University of Toronto, Canada; (2) Princess Margaret Cancer Center, Canada

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542 Role of Cancer-Associated Fibroblasts on Drug Response of Pancreatic Cancer Using Tumor-Microenvironment-on-Chip
Presenter: Han, Bumsoo. Authors: A. OZCELIKKALE (1), A. Conteh (2), M. Korc (2), B. Han (1)
(1) Purdue University, U.S.A.; (2) Indiana University School of Medicine, U.S.A.

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543 “EPR domino”: Boosting EPR effect of nanomedicine by using nitric oxide-releasing liposome
Presenter: Yoshikawa, Takuma. Authors: T. YOSHIKAWA (1), Y. Tahara (1), A. Kishimura (1), T. Mori (1), Y. Katayama (1)
(1) Kyushu University, Japan

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544 Junction opener protein increases nanoparticle accumulation in solid tumors in a size-dependent manner
Presenter: Wang, Christine. Authors: C. WANG (1), R. Yumul (1), A. Lieber (1), S. Pun (1)
(1) University of Washington, U.S.A.

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545 S-Nitrosated human serum albumin dimer as a novel nano EPR enhancer applied to nanotechnology based anticancer drugs
Presenter: Kinoshita, Ryo. Authors: R. KINOSHITA (1), Y. Ishima (1)
(1) Kumamoto University, Japan

View Abstract

546 Assembly, Biocompatibility and Use of Platinum Nanoparticles as Radiation Dose Enhancers
Presenter: Brown, Anna. Authors: A. BROWN (1)
(1) Oregon State University/Oregon Health and Science University College of Pharmacy, U.S.A.

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547 Nano-CaCO3 as a pH sensitive therapeutic platform for modulating the tumor extracellular environment
Presenter: Som, Avik. Authors: A. SOM (1), R. Raliya (1), L. Tian (1), W. Akers (1), J. Ippolito (1), S. Singamaneni (1), P. Biswas (1), S. Achilefu (1)
(1) Washington University in St. Louis, U.S.A.

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548 Formulation and Delivery of Mono-N-Oxide Vinblastine Liposomal Formulation for Targeting Non-Small Lung Cancer with Hypoxic Environments.
Presenter: Shah, Vidhi. Authors: V. SHAH (1), D. Nguyen (1), A. Alani (1)
(1) Oregon State University, U.S.A.

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549 Potential Positive Effect of Dexamethasone as Penetration Enhancer on Effectiveness of Intra-Tumoral Drug Delivery Systems
Presenter: Stepensky, David. Authors: D. STEPENSKY (1), H. Popilski (1), E. Abtew (2), S. Schwendeman (3), A. Domb (2)
(1) Ben-Gurion University of the Negev, Israel; (2) The Hebrew University of Jerusalem, Israel; (3) University of Michigan, Ann Arbor, U.S.A.

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collapse Preclinical Science Challenges to Drug Delivery

24 Comparative aspects of drug transporters in companion animals: Implications for drug delivery
Presenter: Mealey, Katrina. Authors: K. MEALEY (1)
(1) Washington State University, U.S.A.

View Abstract

25 Organs-on-Chips: a Living Platform for Generating Human Relevant Data
Presenter: Kerns, S. Jordan. Authors: S. KERNS (1)
(1) Emulate, Inc., U.S.A.

View Abstract

550 A Drug Selection Approach for Targeted Inhibition of Atherosclerotic Plaque Inflammation
Presenter: Alaarg, Amr. Authors: A. ALAARG (1)
(1) Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029,U, U.S.A.

View Abstract | View Presentation

551 In vitro-ex vivo correlations between a novel cell-laden hydrogel and mucosal tissue for screening composite delivery systems
Presenter: Blakney, Anna. Authors: A. BLAKNEY (1), A. Little (1), Y. Jiang (1), K. Woodrow (1)
(1) University of Washington, U.S.A.

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552 The Combination of BIBF 1120 (BIBF) and Paclitaxel (PTX) Independently Loaded in PLGA Nanoparticles as a Treatment for Endometrial Cancer (EC)
Presenter: Do, Anh-vu. Authors: K. EBEID (1), X. Meng (2), A. Do (1), A. Wongrakpanich (3), S. Geary (1), K. thiel (2), K. leslie (2), A. Salem (1)
(1) University of Iowa, Pharmacy school, U.S.A.; (2) University of Iowa, U.S.A.; (3) Mahidol University, Thailand

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553 High Capacity GCPQ Polymer Nanoemulsion Allows Efficient Delivery of Disulfiram for Cancer Therapy
Presenter: Abd Kadir, Erazuliana. Authors: E. ABD KADIR (1), A. Schatzlein (1), I. Uchegbu (1)
(1) UCL School of Pharmacy, University College London, United Kingdom

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554 Cisplatin-conjugated gold nanoparticles for improved radiotherapeutic effects in in vitro models of triple negative breast cancer
Presenter: Her, Sohyoung. Authors: S. HER (1), L. Cui (1), D. Jaffray (2), R. Bristow (2), C. Allen (1)
(1) University of Toronto, Canada; (2) University of Toronto, Princess Margaret Cancer Centre, Canada

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555 Topical vs Oral Drug Delivery to Synovial Fluid and Plasma of Rats
Presenter: Bhyrapuneni, Gopinadh. Authors: G. BHYRAPUNENI (1), N. Muddana (1), K. Kurapati (1), D. Dogiparti (1), N. Patibandla (1), D. Sisodaya (1), R. Eeda (1), B. Devarapalli (1), N. Padala (1), D. Ajjala (1), R. Nirogi (1)
(1) Suven Life Sciences Limited, India

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556 Simultaneous Assessment of Formulation Effect on Dissolution, Solubility and Trans-membrane Flux of Compounds
Presenter: Kwajewski, David. Authors: D. KWAJEWSKI (1), K. Tsinman (1), O. Tsinman (1)
(1) Pion Inc., U.S.A.

View Abstract

557 Two types of systemic lymphatic uptake of macromolecules
Presenter: Papisov, Mikhail (Misha). Authors: M. PAPISOV (1), D. Levine (2), V. Belov (1), A. Fischman (3), J. Appleton (2), B. durcanova (2)
(1) Massachusetts General Hospital & Harvard Medical School, U.S.A.; (2) Massachusetts General Hospital, U.S.A.; (3) Shriners Hospitals for Children, U.S.A.

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559 Magnetically and pH responsive dendrosomes for tumor-targeted hybrid drug delivery
Presenter: Sun, Kaoxiang. Authors: K. SUN (1), M. Wang (2), A. Wang (1), W. Liu (1), Y. Li (1)
(1) School of Pharmacy, Yantai University/Shandong Luye Pharmaceutical Co., Ltd., China; (2) School of Pharmacy, Yantai University, China

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560 Evaluation of Efficacy and Toxicity of a Bone-targeted pH-sensitive Liposomal Formulation Containing Doxorubicin in an Animal Model of Breast-metastatic Tumor in Bones
Presenter: dos Santos Ferreira, Diego. Authors: D. DOS SANTOS FERREIRA (1), B. Oliveira (1), C. Farrar (1), P. Caravan (1), M. Oliveira (2), A. Guimaraes (1)
(1) Massachusetts General Hospital/Harvard Medical School, U.S.A.; (2) Universidade Federal de Minas Gerais, Brazil

View Abstract
collapse Predictive Modeling in Delivery and Targeting (Scaling: Mouse to Man; Probability of Reaching Targets; Stochastic Process in System Distribution)

26 Consideration of Dynamic Factors for Cancer Models and Modeling
Presenter: Bae, You Han. Authors: Y. BAE (1)
(1) University of Utah, U.S.A.

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563 Multi-scale Modeling of Drug Release through Polymer Hydrogels
Presenter: Pareek, Aditya. Authors: A. PAREEK (1), B. Dwadasi (1), R. Gupta (1), B. Rai (1), V. Runkana (1)
(1) TRDDC-TCS Innovation Labs, India

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564 Evaluation of in vitro tests to reduce animal testing in drug toxicology studies
Presenter: Mole, Jon. Authors: J. MOLE (1), K. Box (2), R. Taylor (2), N. Fotaki (3), M. McAllister (4)
(1) Sirius Analytical Inc., U.S.A.; (2) Sirius Analytical, United Kingdom; (3) University of Bath, United Kingdom; (4) Pfizer, United Kingdom

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565 Gaussian Processes: Towards better modelling of drug-loading in solid lipid nanoparticles
Presenter: Hathout, Rania. Authors: R. HATHOUT (1)
(1) Ain Shams University, Egypt

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566 Targeting and altering in vivo macrophage responses with modified polymer properties
Presenter: Bratlie, Kaitlin. Authors: K. BRATLIE (1), H. Bygd (1), K. Forsmark (1)
(1) Iowa State University, U.S.A.

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collapse Taking Stock of Progress and Challenges in Drug Delivery and Targeting

27 Correlative, Causative, Curable and Credible: Reliability, Truth and Accuracy in Research Reporting
Presenter: Grainger, David. Authors: D. GRAINGER (1)
(1) University of Utah, U.S.A.

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567 Development of PEGylated carboxylic acid modified polyamidoamine dendrimer as a bone targeting carrier for the treatment of bone diseases
Presenter: Yamashita, Shugo. Authors: S. YAMASHITA (1), H. Katsumi (1), N. Hibino (1), Y. Isobe (1), Y. Yagi (1), K. Kusamori (1), T. Sakane (1), A. Yamamoto (1)
(1) Kyoto Pharmaceutical University, Japan

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568 Incorporation of taxol binding peptide enhances drug loading in polymeric micelles
Presenter: Logie, Jennifer. Authors: J. LOGIE (1), C. McLaughlin (1), A. Ganesh (1), M. Shoichet (1)
(1) University of Toronto, Canada

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569 Natural nanoparticles inspired specific-targeted co-delivery of siRNA and paclitaxel for collaborative antitumor therapy
Presenter: Wang, Ruoning. Authors: R. WANG (1), Y. Ding (1), J. Zhou (1)
(1) China Pharmaceutical University, China

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570 Rerouting high-density lipoproteins to specific alternate receptors for improved tumor-targeted siRNA delivery
Presenter: Ding, Yang. Authors: Y. DING (1), Y. Han (1), R. Wang (1), J. Zhou (1)
(1) China Pharmaceutical University, China

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572 Development of Thermoresponsive Liposomes Aimed at Temperature-controlled Cellular Uptake
Presenter: Kanazawa, Hideko. Authors: H. KANAZAWA (1), R. Nemoto (1), J. Wang (1), Y. Hiruta (1), M. Hishida (2), E. Ayano (1), Y. Maitani (1)
(1) Keio University, Japan; (2) University of Tsukuba, Japan

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573 Pharmacokinetic and Tumour distribution properties of doxorubicin conjugated PEGylated dendrimers
Presenter: Mehta, Dharmini. Authors: D. MEHTA (1), L. Kaminskas (1), N. Leong (1), D. Owen (2), B. Kelly (2), R. Pathak (2), C. Porter (1)
(1) Monash Institute of Pharmaceutical Sciences, Monash University, Australia; (2) Starpharma Pvt.Ltd., Australia

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574 Cancerous SKOV-3 Exosomes Can Be Detected by Using Specific LXY30 Targeting Peptide
Presenter: Rojalin, Tatu. Authors: T. ROJALIN (1), R. Carney (2), T. Viitala (1), S. Hazari (2), S. Wachsmann-Hogiu (2), K. Lam (2), M. Yliperttula (1)
(1) University of Helsinki, Finland; (2) University of California Davis, U.S.A.

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575 Prodrug Encapsulation into Polymer Nanoparticles : Formulation Optimization and Rationale for In Vitro Screening Methods
Presenter: Wattamwar, Paritosh. Authors: P. WATTAMWAR (1), A. Drager (1)
(1) Teva Pharmaceuticals, U.S.A.

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576 Combination of Nanoparticle-Delivered Sirna for Astrocyte Elevated Gene-1 (AEG-1) and All-Trans Retinoic Acid (ATRA): a Therapeutic Strategy for Hepatocellular Carcinoma (HCC)
Presenter: Ebeid, Kareem. Authors: K. EBEID (1), D. Sarkar (2), A. Salem (1), M. Akiel (2)
(1) University of Iowa, Pharmacy school, U.S.A.; (2) virginia commonwealth university, U.S.A.

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577 Core-Shell Magnetic Nanoparticle for Application in Magnetic Hyperthermia
Presenter: Albarqi, Hassan. Authors: H. ALBARQI (1), C. schumann (1), X. Li (1), O. Taratula (1), O. Taratula (1)
(1) Oregon State Univeristy, U.S.A.

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578 The next generation active delivery strategies exploring non-competitive ligands to the receptor
Presenter: Ganugula, Raghu. Authors: R. GANUGULA (1), P. Saini (1), M. Arora (1), M. Kumar (1)
(1) Texas A&M Health Science Center, U.S.A.

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579 POLA-b-POEGMA: A Comb Polymer Analogue of PLA-b-PEG for Nanoparticle Drug Delivery
Presenter: Sadowski, Lukas. Authors: L. SADOWSKI (1), T. Hoare (1), D. Luo (1)
(1) McMaster University, Canada

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580 Molecular targeting to enhance nanoparticle association during ex vivo perfusion of human kidney
Presenter: Tietjen, Gregory. Authors: G. TIETJEN (1), W. Saltzman (1), S. Hosgood (2), J. Pober (1), N. Kirkiles-Smith (1), J. Cui (1), M. Nicholson (2), E. Bolton (2), J. Bradley (2), K. Saeb-Parsy (2), J. Bradley (2)
(1) Yale university, U.S.A.; (2) University of Cambridge, United Kingdom

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581 CD44-Targeted Calcium Phosphate Nanoparticles for Anticancer Drug Delivery
Presenter: Suh, Min sung. Authors: M. SUH (1), M. Kastellorizios (1), L. Kuhn (2), D. Burgess (1)
(1) University of Connecticut, U.S.A.; (2) University of Connecticut Health Center, U.S.A.

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583 What are the most important controlled release products of all time?
Presenter: Tucker, Ian. Authors: I. TUCKER (1)
(1) University of Otago, New Zealand

View Abstract | View Presentation
collapse Thinking Outside the Box Delivery Technologies: Nanocarriers from Nature

28 Exosome mimetics-based platform technology for targeted drug delivery and adjuvant-free vaccine
Presenter: Gho, Yong Song. Authors: Y. GHO (1)
(1) POSTECH, Korea

View Abstract

584 Dendritic cells derived extracellular vesicles for the combinational therapy against tumor
Presenter: Zhang, Zhiping. Authors: Z. ZHANG (1), T. wu (1), D. zhang (1)
(1) Huazhong University of Science and Technology, China

View Abstract

585 Neutrophil membrane-formed Nanovesicles for Vascular Targeting Delivery
Presenter: Wang, Zhenjia. Authors: Z. WANG (1)
(1) Washington State University, U.S.A.

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586 Endosomal FcRn-dependent Trafficking of Albumin
Presenter: Larsen, Maja Thim. Authors: M. LARSEN (1), J. Cameron (2), D. Viuff (3), M. Hvam (1), K. Howard (1)
(1) Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark; (2) Albumedix Ltd, Castle Court, 59 Castle Boulevard, Nottingham, NG7 1FD, United Kingdom, United Kingdom; (3) Novozymes A/S, Brudelysvej 32, 2880 Bagsværd, Denmark, Denmark

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587 Long circulating Ferritin Nanocage with 'Protein cloud'
Presenter: Lee, Na Kyeong. Authors: N. LEE (1), E. Lee (1), K. Nam (1), Y. Byun (2), I. Kim (1)
(1) Korea Institute of Science and Technology, South Korea; (2) Seoul National University, South Korea

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588 Enzymatic and Anti-Tumorigenic Effect of PH20-Expressing Exosome
Presenter: Hong, Yeonsun. Authors: Y. HONG (1), I. Kim (1), Y. Yang (1)
(1) Korea Institute of Science and Technology, Korea

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589 Sonodynamic Therapy Using Tumor-Targetable Titanium Oxide Nanoparticles
Presenter: Um, Wooram. Authors: W. UM (1), D. YOU (1), D. VG (1), J. PARK (1)
(1) Sungkyunkwan University, Korea

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590 Timeresolved fluorescence microscopy imaging of paclitaxel loaded extracellular vesicles in prostate cancer cells
Presenter: Niemi, Liisa. Authors: L. NIEMI (1)
(1) University of Helsinki, Finland

View Abstract

591 Fusogenic exosomes as a platform for therapeutic applications
Presenter: Yang, Yoosoo. Authors: Y. YANG (1), Y. Hong (1), E. Koh (1), I. Kim (1)
(1) Korea Institute of Science and Technology, Korea

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collapse Tissue Engineering

29 The Tissue Engineering-Drug Delivery Intersection
Presenter: Ratner, Buddy. Authors: B. RATNER (1)
(1) University of Washington, U.S.A.

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30 Modular Inductive High-Density Cell Culture Systems for Engineering Complex Tissues
Presenter: Alsberg, Eben. Authors: E. ALSBERG (1)
(1) Case Western Reserve University, U.S.A.

View Abstract

592 Transdermal Delivery of Bone-Targeting Peptide Hormone Conjugates for Treatment of Shin Splints Using Liposomal Cream Base: Pharmacokinetic and Tissue Distribution Study
Presenter: Doschak, Michael. Authors: A. AGHAZADEH-HABASHI (1), K. Tang (1), R. Loebenberg (1), M. Doschak (1)
(1) University of Alberta, Canada

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593 Modified RNA Activated Matrices Enhance Bone Regeneration
Presenter: Khorsand-Sourkohi, Behnoush. Authors: B. KHORSAND-SOURKOHI (1), S. Elangovan (1), A. Do (1), L. Hong (1), A. Dewerth (2), M. Kormann (2), R. Ross (3), D. Sumner (3), A. Salem (1)
(1) The University of Iowa, U.S.A.; (2) University of Tübingen, Germany; (3) Rush Medical College, U.S.A.

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594 Controlled and sequential delivery of fluorophores from 3D Printed alginate-PLGA devices
Presenter: Do, Anh-Vu. Authors: A. DO (1), A. Akkouch (1), B. Green (1), I. Ozbolat (1), A. Debaneh (1), A. Salem (1)
(1) The University of Iowa, U.S.A.

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595 Novel Starch-based 3D Scaffolds as Dermal Substitute for Skin Tissue Engineering
Presenter: Chhabra, Rohan. Authors: R. CHHABRA (1), P. Dandekar Jain (1)
(1) Institute of Chemical Technology, India

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596 Stem Cell/Microsphere Aggregates Using Cell-Instructive Polymers
Presenter: An, Hyoseok. Authors: H. AN (1)
(1) Department of Bioengineering/Hanyang University, Korea

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597 Novel thin heparin-functionalized hydrogel-coatings for controlled VEGF release
Presenter: Claassen, Christiane. Authors: C. CLAAßEN (1), L. Sewald (2), G. Tovar (1), B. Stanzel (3), K. Borchers (2)
(1) Institute for Interfacial Process Engineering and Plasma Technology IGVP, University of Stuttgart, Germany; (2) Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany; (3) Department of Ophthalmology, University of

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598 A bioabsorbable composite patch for esophageal reconstruction
Presenter: Dorati, Rossella. Authors: B. CONTI (1), R. Dorati (2), A. DeTrizio (2), I. Genta (2), T. Modena (2), M. Benazzo (3), A. Benazzo (3), G. Volpato (3)
(1) University of Pavia, Department of Drug Sciences, Italy; (2) Department of Drug Sciences, University of Pavia, Italy, Italy; (3) Dept. Otolaryngology/Head and Neck Surgery, University of Pavia, I.R.C.C.S. Policlinico S. Matteo, Pavia, Italy, Italy

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599 Fabrication of starch-based nanofibrous mats for wound healing applications
Presenter: Dandekar Jain, Prajakta. Authors: P. WADKE (1), P. Dandekar Jain (1), V. Vaghmare (1), R. Jain (1)
(1) Institute of Chemical Technology, India

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600 In vitro and In vivo Evaluation of Controlled Payload Release using Acoustically-Responsive Scaffolds
Presenter: Moncion Baez, Alexander. Authors: A. MONCION BAEZ (1), O. Kripfgans (2), R. Franceschi (3), A. Putnam (4), M. Fabiilli (2)
(1) Applied Physics Program, University of Michigan, U.S.A.; (2) Department of Radiology, University of Michigan Health System, U.S.A.; (3) School of Dentistry, University of Michigan, U.S.A.; (4) Department of Biomedical Engineering, University of Michig

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601 Swelling, Diffusion and Internal Structure Change of PLGA Microsphere/PVA Hydrogel Composite Coatings for Implantable Glucose Sensors
Presenter: Gu, Bing. Authors: B. GU (1), F. Papadimitrakopoulos (1), D. Burgess (1)
(1) University of Connecticut, U.S.A.

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602 Blebbistatin-Loaded Poly (D,L lactide-co-glycolide) Particles For Treating Arthrofibrosis
Presenter: Atluri, Keerthi. Authors: K. ATLURI (1), A. Jesus (1), S. Chinnathambi (1), S. Chinnathambi (1), J. Martin (1), A. Salem (1), E. Sander (1)
(1) University of Iowa, U.S.A.

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603 Differentially Controlled Release of Several Bioactive Molecules from a Multilayer Nanofiber-Hydrogel Scaffold
Presenter: Man, Dula. Authors: D. MAN (1), R. Wu (1)
(1) Delaware State University, U.S.A.

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604 Gene Activated Titanium Surface Promote In Vitro Osteogenesis
Presenter: Atluri, Keerthi. Authors: K. ATLURI (1), L. Joun (1), D. Seabold (1), S. Elangovan (1), A. Salem (1)
(1) University of Iowa, U.S.A.

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605 Implantable Poly(DL-lactide-co-glycolide) loaded with N-Acetylcysteine prevents severe post-traumatic osteoarthritis
Presenter: Khorsand-Sourkohi, Behnoush. Authors: B. KHORSAND-SOURKOHI (1), A. Morris (1), M. Mesghali (1), M. Coleman (1), J. Martin (1), A. Salem (1)
(1) The University of Iowa, U.S.A.

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606 Injectable Self-assembled Gelatin Cell Constructs for Tissue Engineering
Presenter: Huang, Yi-You. Authors: Y. HUANG (1)
(1) National Taiwan University, Taiwan

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607 Engineering the Microenvironment of Lymphoid Tissue to Promote Antigen-specific Immune Tolerance
Presenter: Jewell, Christopher. Authors: C. JEWELL (1)
(1) University of Maryland - College Park, U.S.A.

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608 3DCellMakers: Thermogelling Polymers for 3D Cell Culture
Presenter: Hadar, Justin. Authors: J. HADAR (1), J. Garner (1), S. Skidmore (1), H. Park (1), K. Park (1), B. Han (2), F. Atrian (2), S. Lelievre (2)
(1) Akina, Inc., U.S.A.; (2) Purdue University, U.S.A.

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collapse Transdermal Delivery

31 Bio-responsive Smart Microneedle Patches
Presenter: Gu, Zhen. Authors: Z. GU (1)
(1) UNC at Chapel Hill / NC State, U.S.A.

View Abstract

32 Hydrogel-forming Microneedles for Drug Delivery and patient monitoring
Presenter: Donnelly, Ryan. Authors: R. DONNELLY (1)
(1) Queen's University Belfast, United Kingdom

View Abstract

609 A chitosan hydrogel sheet containing cross-linkable polymeric micelles for wound dressing and drug release
Presenter: Ito, Tomoki. Authors: Y. MURAKAMI (1), T. Ito (1), T. Takami (1)
(1) Tokyo University of Agriculture and Technology, Japan

View Abstract

610 Novel transdermal delivery system using dissolving microneedle and translational research
Presenter: Kim, Hong Kee. Authors: H. KIM (1), J. Kim (1), J. Bae (1), Y. Ahn (1), Y. Lee (1), T. Kim (1), D. Jeong (1)
(1) RAPHAS, South Korea

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611 Nitric Oxide-Releasing Polymer Incorporated Ointment for Cutaneous Wound Healing
Presenter: Kang, Youngnam. Authors: Y. KANG (1), J. Kim (2), Y. Lee (2), S. Im (2), H. Park (3), W. Kim (2)
(1) POSTECH, Korea; (2) POSTECH, South Korea; (3) Chung-Ang University, South Korea

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612 A novel chitosan-based film forming topical formulations of terbinafine: comparative study of skin permeation and retention
Presenter: Han, Sang-Dug. Authors: M. KANG (1), K. Lee (1), S. Han (1), J. Jun (1), M. Son (1)
(1) Dong-a ST, Korea

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613 Preparation of bilayed loaded liposomes via sonication
Presenter: Stone, Peter. Authors: P. STONE (1), A. Rozhin (1), J. Kroonen (2), Y. Perrie (1)
(1) Aston University, United Kingdom; (2) Diagenode, Belgium

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614 Preparation and Characterization of Microemulsion Based Hydrogel Containing Celecoxib for Topical Delivery
Presenter: Hwang, Kyu-Min. Authors: K. HWANG (1), J. Seo (1), K. Hwang (1), C. Cho (1), J. Min (1), T. Nguyen (1), S. Kim (1), S. Seok (1), E. Park (1)
(1) School of Pharmacy, Sungkyunkwan University, South Korea

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615 Carboxylated nanodiamond as a topical drug delivery vehicle: stability and permeation-enhancing effect
Presenter: Lim, Dae Gon. Authors: D. LIM (1), K. Kim (1), E. Kang (2), S. Lim (3), J. Ricci (3), S. Sung (3), M. Kwon (3), S. Jeong (4)
(1) Dongguk University, South Korea; (2) Chung-Ang University, Korea; (3) NanoResource Co. Ltd, Korea; (4) Dongguk University, Korea

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616 Hyaluronate - Upconversion Nanoparticle Conjugate for Deep Tissue Photomedicine
Presenter: Han, Seulgi. Authors: S. HAN (1), H. Kim (1), S. Hahn (1)
(1) POSTECH, Korea

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617 Thermoresponsive nanogel mediated protein replacement therapy restores skin-barrier function to full-thickness skin models derived from Transglutaminase 1 deficient patients
Presenter: Yealland, Guy. Authors: G. YEALLAND (1), R. Plank (2), K. Obst (3), E. Miceli (4), M. Molina (4), K. Eckl (5), M. Calderón (6), H. Hennies (2), S. Hedtrich (1)
(1) Institute for Pharmaceutical Sciences, FU-Berlin, Germany; (2) Dept. of Biological Sciences University of Huddersfield, UK, United Kingdom; (3) Institute of Pharmaceutical Sciences Freie Universität Berlin, Germany, Germany; (4) Institute of Chemistry

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618 A novel gel formulation with nanoscale cavitation nucleation agent and OVA for ultrasound-assisted transdermal vaccine delivery and generation of anti-OVA antibodies in mice
Presenter: Carlisle, Robert. Authors: S. BHATNAGAR (1), J. Kwan (1), A. Shah (1), R. Carlisle (1), C. Coussios (1)
(1) University of Oxford, United Kingdom

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619 Design and in vitro evaluation of a gentamicin-containing hydrogel-forming microneedle patch intended to treat neonatal sepsis
Presenter: Donnelly, Ryan. Authors: R. DONNELLY (1)
(1) Queen's University Belfast, United Kingdom

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620 Transform™ Polymer Films: Rapid Drug Delivery Hydrogels
Presenter: Marchant, Nancy. Authors: N. MARCHANT (1), Q. Tang (1), T. Ramezanli (2), B. Michniak-Kohn2 (3), M. Vyakarnam (1)
(1) Lubrizol, U.S.A.; (2) Ernest Mario School of Pharmacy and Center for Dermal Research, Rutgers, U.S.A.; (3) Ernest Mario School of Pharmacy and Center for Dermal Research, Rutgers – The State University of New Jersey, U.S.A.

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621 Cationically charged Phospholipid Structured Nanoemulsion of Anti-infectives: Improved Dermatokinetic Profile and Therapeutic Efficacy in the treatment of Burn Wound Infection
Presenter: Thakur, Kanika. Authors: K. THAKUR (1), G. SHARMA (2), B. SINGH (3), S. CHHIBBER (4), O. KATARE (2)
(1) UGC Centre of Advanced Studies, University Institute of Pharmaceutical Sciences, Panjab University,, India; (2) UGC Centre of Advanced Studies, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India, India; (3) U

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622 Towards development and validation of the Dermal PBPK model for virtual bioequivalence - model description and validation case studies
Presenter: Patel, Nikunjkumar. Authors: S. POLAK (1), N. Patel (1), S. Cristea (1)
(1) Simcyp (part of Certara), United Kingdom

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623 Biolistic Delivery of pDNA-coated Particles with a MEMS Device Shows SEAP Expression in Mice
Presenter: Pirmoradi, Fatemeh Nazly. Authors: F. PIRMORADI (1), M. Recht (1), T. Brubaker (1), M. Jethi (1), M. Sheridan (1), E. Chow (1), F. Linn (1), M. Veiseh (1), A. Pattekar (1), A. Völkel (1)
(1) Palo Alto Research Center Inc. (PARC), U.S.A.

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624 Nicotine delivery rates from programmable carbon nanotube membrane-based transdermal delivery device as determined by microdialysis method
Presenter: Gulati, Gaurav Kumar. Authors: G. GULATI (1), T. Chen (2), B. Hinds (1)
(1) University of Washington, U.S.A.; (2) University of kentucky, U.S.A.

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625 Development of transdermal drug delivery system for paroxetine
Presenter: Choi, Hoo-Kyun. Authors: H. CHOI (1), D. Im (1)
(1) Chosun University, Korea

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627 Nano-Encapsulated Cyclosporine A for Dermal Treatment
Presenter: Badihi, Amit. Authors: A. BADIHI (1), M. Frušic-Zlotkin (1), Y. Soroka (1), T. Nassar (1), S. Benita (1)
(1) Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel

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628 Preparation and characterization of solid lipid nanoparticles containing capsaicin by the emulsification-diffusion method
Presenter: Cervantes Covarrubias, Paola. Authors: P. CERVANTES COVARRUBIAS (1), K. Palomino (1), A. Serrano Medina (1), J. Cornejo Bravo (1)
(1) Autonomous University of Baja California, Mexico

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630 Development of hollow microneedle device for intradermal vaccination
Presenter: Kodama, Yoshihiro. Authors: Y. KODAMA (1), T. Sumida (1), S. Naito (2)
(1) Toppan Printing Co., LTD., Japan; (2) National Institute of Infectious Diseases, Japan

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631 Utility of Strat-M membrane for formulation optimization in transdermal diffusion testing
Presenter: Joshi, Vivek. Authors: V. JOSHI (1)
(1) EMD Millipore Corp., U.S.A.

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633 Development of a liposomal formulation for the dermal delivery of active agents
Presenter: Lowry, Deborah. Authors: M. MARWAH (1)
(1) Aston University, United Kingdom

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634 Development of topical preparation for novel antibacterial compound NCL812
Presenter: Song, Yunmei (May). Authors: K. KATHAWALA (1), P. Sim (1), Y. Song (1), E. Hickey (2), S. Page (3), M. Khazandi (2), D. Trott (2), S. Garg (1)
(1) University of South Australia, Australia; (2) University of Adelaide, Australia; (3) Neoculi Pty Ltd, Burwood, Victoria 3125, Australia, Australia

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635 Bacillus subtilis alkaline protease as a potential biological skin permeation enhancer
Presenter: Nounou, Mohamed. Authors: M. NOUNOU (1), N. Ahmed (2), A. Abouelfetouh Eid (2), T. Zaghloul (2), L. El-Kourdagui (2)
(1) Appalachian College of Pharmacy, U.S.A.; (2) Alexandria University, Egypt

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636 Controlled Anodal Iontophoretic Delivery of Biolabile Hydrosoluble Raloxifen Prodrugs
Presenter: Serna Jimenez, Cesar Eulogio. Authors: C. SERNA JIMENEZ (1), Y. Kalia (1), Y. Chen (1), S. Kandekar (1), V. Santer (1)
(1) University of Geneva, Switzerland

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637 Evaluation of Fractional Laser Ablation for the Controlled Transdermal Delivery of Paliperidone and the Development of a Mathematical Model for Laser-Assisted Drug Transport
Presenter: Serna Jimenez, Cesar Eulogio. Authors: C. SERNA JIMENEZ (1), Y. Kalia (1), A. Lopez Castellano (2), V. Merino Sanjuan (3), I. Alberti (1)
(1) University of Geneva, Switzerland; (2) Universidad CEU Cardenal Herrera, Spain; (3) Universidad de Valencia, Spain

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