Bioadhesive Double-Walled Nanospheres as an Oral Insulin Delivery Platform

D.Y. Cho1, C. Tian1, K.M Estrellas1, Y.T. Liu1, J.J. Reineke2, S. Furtado1, and E. Mathiowitz1

1Brown University, Providence, RI, 02903, USA; 2Wayne State University, Detroit, MI, 48201, USA. daniel_cho@brown.edu

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Summary
We present the analysis of our quantitative uptake studies of particle translocation from the small intestine and studies of insulin nanoencapsulation that have guided the development of a potential oral drug delivery platform based on bioadhesive double-walled nanospheres (NS). Using predictive methods, we have determined the theoretical efficacy of our lead formulation, which has the potential to deliver up to 33.54 IU of insulin from a dose of 25 mg of NS.

 

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