Prolonged Pulmonary Vasodilation by Inhaled Liposomes of Fasudil in Monocrotaline (MCT) Induced Rat Model of PAH

Nilesh Gupta¹,*, Vivek Gupta¹,* and Fakhrul Ahsan¹

¹School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA *Equal Contribution nilesh.gupta@ttuhsc.edu Phone: 806-356-4015x233

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Summary
This study tests the efficacy of inhalable liposomes of fasudil, a novel Rho-kinase inhibitor, in providing sustained pulmonary vasodilation in monocrotaline induced rat model of pulmonary arterial hypertension (PAH), thus eliminating the need for multiple dosing. The results indicated that a single administration of inhalable liposomes produced a significant decrease in mean pulmonary arterial pressure (MPAP) for up to 3 hrs, while keeping the systemic pressure in the normal range.