Preparation of pNIPAM-modified Gold Nanorods and Their Delivery to Specific Tissue

T. Niidome1,2,3, A. Shiotani1, T. Mori1,2, and Y. Katayama1,2

1Faculty of Engineering, Kyushu University, Fukuoka 819-0395, Japan; 2Center for Future Chemistry, Kyushu University, Fukuoka 819-0395, Japan; 3PRESTO, Japan Science and Technology Agency, Kawagushi 332-0012, Japan


Thermosensitive polymer gel-coated gold nanorods were prepared by precipitation polymerization of NIPAM and co-monomer (DMAA or AAm) that was added to tune phase transition temperature above body temperature. PNIPAM-DMAA and PNIPAM-AAm-coated gold nanorods showed phase transition temperature at 38ºC and 41ºC, respectively. After intravenous injection of the gel modified gold nanorods and irradiation of near infrared laser to a tumor, the larger amount of gold was detected in the irradiated tumor than in the non-irradiated tumor. It would be due to the hydrophobic interaction between cellular membrane or extracellular matrix and gel surfaces induced by the photothermal effect of gold nanorods.

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