Polymeric styrene maleic acid-miceller anticancer drugs: Enhanced antitumor activity-based on EPR-effect in solid tumors.

 

Khaled Greish and Hiroshi Maeda. Department of Microbiology, Jumamoto University. Department of Pharmaceutics, Sojo University, Japan.

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Summary
This presentation describes the use of permeability and retention effect to target anti-cancer drugs selectively and how styrene maleic acid-miceller drugs enhance the effect. The AUC of this micelle is more than 40% higher than free THP and 13 times better in tumor concentration.

 

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