PEO-PPO-PEO Block Co-Polymers and Bio-Membrane Interactions: A Structure Based Relationship

M. Redhead1, G. Mantovani1, C. Alexander1 and C. Bosquillon1

1School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK;


A putative relationship between the structure of PEO-PPO-PEO block co-polymers and their interactions with biological membranes was developed. A combination of cytotoxicity and haemolysis assays were used to show a direct correlation between cytotoxic effects and the membrane binding constant of the PEO-PPO-PEO block co-polymers. Both cytotoxicity and the strength of membrane interaction were found to depend on the chemical composition of the co-polymers; with a 2D parabolic relationship existing between the chemical components of the PEO-PPO-PEO block co-polymers and their effect on biological membranes.

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