S. Rehder1, M. Klukkert2, C.J. Strachan2, A. Sakmann1, T. Rades2, and C. S. Leopold1
1Institute of Pharmacy, University of Hamburg, Hamburg, Germany; 2School of Pharmacy, University of Otago, Dunedin, New Zealand email@example.com
The aim of this study was to examine the applicability of Raman spectroscopy in combination with chemometrics for the investigation of piracetam cocrystal formation during different grinding procedures. As a model API, polymorphic forms I and III of piracetam were used. Cocrystal former was L-tartaric acid. It could be shown that physical mixing did not succeed in forming cocrystals. On the other hand, cocrystals were formed within 1 min by solvent drop grinding. Raman spectroscopy revealed time-dependent cocrystal formation of piracetam/L-tartaric acid during dry-grinding at the applied milling times.