Reducible Poly(Oligo-D-Arginine) for Delivery of Vascular Endothelial Growth Factor siRNA Effectively Suppresses Growth of Squamous Cell Carcinoma

Young-Wook Won, Yong-Hee Kim

Department of Bioengineering, Hanyang University, 17, Haengdang-dong, Seongdong-gu, Seoul, 133-791, Republic of Korea,
darkne@hanyang.ac.kr

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ABSTRACT SUMMARY
Reducible poly(oligo-D-arginine) was developed as an efficient carrier of siRNA silencing vascular endothelial growth factor (VEGF) to suppress tumor growth by the anti-angiogenesis mechanism. This polymer effectively condensed and stabilized siVEGF by forming nano-particular assemblies, and represented inhibition of VEGF production in vitro and retarded tumor growth in vivo.

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