Controlled Protein Release from Microparticles as Mechanism to Concentrate Drugs within Scaffolds

R. Qodratnama1, H. Cox1, L. White1

1 Wolfson Centre for Stem Cell, Tissue Engineering and Modelling (STEM), Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, NG7 2RD, UK. Paxrg1@nottingham.ac.uk

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Summary
The controlled release of proteins within a scaffold is a key strategy in regenerative medicine. The protein may act as an angiogenic factor or a growth factor to stimulate tissue formation. To achieve these functions the protein must be presented in an active form within the therapeutic window for sufficient time to complete the tissue formation process.

In this abstract we present an approach to control protein release from poly(lactic acid-co-glycolic acid) (PLGA) microparticles (MP). The approach uses a surfactant to accelerate water penetration and the early stages of protein release.

Our approach involves the synthesis of two ABA triblock polymers composed of PLGA and poly(ethylene glycol) (PEG). Release of lysozyme and FITC-labelled lysozyme (Lyso-FITC) from microparticles from different polymer formulations is reported. These data supports the concept that ABA triblocks containing PEG alter the release profile from PLGA microparticles.

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