Young Scientist Workshop I:
Improving the Solubility of Poorly Soluble Drugs

July 10, 2010 in Portland, OR

Chairs: Raid Alany, University of Auckland, New Zealand, and Ron Ortiz, Upsher-Smith Labs, U.S.A.

Technological advances in drug discovery have revolutionized the efficiency of lead identification. However, the promise of new chemical entities (NCEs) as suitable drug treatments can only be fulfilled if they can be successfully formulated and administered in vivo. One of the major barriers to the development of many NCEs is their poor solubility in aqueous media. This complimentary Young Scientist workshop introduced the audience to the science underpinning the technologies for improving drug aqueous solubility. The secrets to successfully formulating a poorly soluble drug using a number of formulation strategies were discussed. Examples of commercialized delivery technologies were presented. The program included

Advances in Technology

Introduction to Poorly Soluble Drugs, Ali Rajabi-Siahboomi, Colorcon, U.S.A.

Technologies for Delivering Poorly Soluble Compounds, Dan Smithey, Agere Pharmaceuticals, U.S.A.

Solid State Modification to Improve Drug Solubility, Paolo Gatti, Eurand, Italy

Optimization and Development of a Cyclodextrin-based IV Formulation of a Poorly Water-Soluble Compound, Sid Patil, Millenium Pharmaceuticals, U.S.A.

Recent Advances on Nano-suspensions, Rajeev Gokhale, Abott Laboratories, U.S.A.

Formulating Poorly Soluble Drugs Using Liposomes, Tom Redelmeier, Northern Lipids Inc., Canada

Advances in Formulations of Poorly Soluble Drugs Using Selfmicroemulsifying Drug Delivery Systems (SMEDDS), Anja Graf, University of Auckland, New Zealand

Spray-dried Dispersions (SDDs) for Solubilization: Immediate and Controlled Release Applications, Brett Caldwell, Bend Research, U.S.A.

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