Scientific Sessions - Veterinary

Prediction and Application of IVIVC for Veterinary Species

Chairs: Michael Rathbone and Jim Riviere

Background: Although the same in vitro constraints and challenges face both human and veterinary scientist's when developing in vitro:in vivo correlations, substantial in vivo challenges are faced by the veterinary formulation scientist in their IVIVC efforts due to the different species they deal with who differ vastly in anatomical, physiological and pharmacological handling of drugs (even within a species). Four invited speakers will address aspects of the various challenges in this area with the goal of identifying current issues, defining existing challenges and presenting recent solutions to shed light on solutions to the complex array of issues.

The potential application of IVIVC for drugs in veterinary species - Where it works and where it deosn't, Mark Papich, North Carolina State University, U.S.A.

Establishing in vivo/in vitro relationships for oral dosage forms in dogs - Issues, challenges and examples, Marilyn Martinez, FDA Center for Vet Medicine, U.S.A.

Use of GastroPlus models in veterinary research and development, Steev Sutton, University of New England, U.S.A.

Use of in vitro dermal penetration models to estimate in vivo absorption of topical dosage forms, Jim Riviere, North Carolina State University, U.S.A.