2014 CRS Annual Meeting Invited Speakers

Plenary Speakers

This year’s program, Translation of Delivery Technology: Innovation to Commercialization, will offer an exceptional opportunity to connect with a diverse audience in the discovery, development, and delivery science continuum. The 2014 CRS Annual Meeting Program Committee has invited an impressive group of plenary speakers, all of whom are working on the cutting edge of science, translating scientific advances into novel innovations.

Plenary Lecture: Monday, July 14, 13:30 - 14:45

Moderator: Ick Chan Kwon

David W. Grainger is a university distinguished professor and chair of the Department of Pharmaceutics and Pharmaceutical Chemistry and a professor of Bioengineering at the University of Utah, U.S.A. Grainger’s research focuses on improving implanted medical device performance using drug delivery; methods to deliver therapeutic proteins, nucleic acids, and live vaccines; nanomaterials interactions with human tissues; low-infection biomaterials; and microarray-based diagnostic devices. Grainger’s expertise extends to surface analysis of biomedical interfaces and nanomaterials. He is an internationally recognized expert in perfluorinated thin films and biomaterials. Grainger has helped found three biomedical technology companies, sits on the scientific advisory boards for four biomedical companies, and actively consults with biomedical industries.

Taking Shape: Transitioning 3D Assays to Improve Drug Screening and Toxicity Predictions

Many new 3D cell culture models seek to preserve in vivo-like organization within tissue-like or organoid constructs to elicit more relevant pharmacological toxicity and toxicity marker upregulation. Validation of 3D tissue culture models against 2D “gold standard cultures” for in vitro toxicological evaluation in drug testing should compare clinical toxicity biomarkers. In vitro 3D organoid models developed to date often confirm that systems with native cellular interactions better ensure biological requirements for sustaining tissue-relevant responses to drugs. These 3D cell culture models can yield better data quality with more accurate, tissue-specific information to significantly improve the technical output, predictive value, and translation between in vitro, animal, and clinical human studies. Further developments using 3D models that yield native extracellular matrix, relevant tissue architectures, and restoration of both chemical and mechanical tissue-like stimulation using bioreactors are critical for advancing in vitro experimental capabilities to obtain clinically relevant in vitro behaviors in drug screening. 

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Plenary Lecture: Tuesday, July 15, 08:00 - 09:30

Moderator: Justin Hanes

Kristi Anseth is a Howard Hughes Medical Institute investigator and distinguished professor of chemical and biological engineering at the University of Colorado at Boulder, U.S.A. Dr. Anseth has authored over 280 manuscripts and presented over 250 invited lectures. Her research interests lie at the interface between biology and engineering, where she designs new biomaterials for applications in drug delivery and regenerative medicine. Dr. Anseth is an elected member of the National Academy of Engineering (2009), the Institute of Medicine (2009), and the National Academy of Sciences (2013).

Drug Delivery to Promote Tissue Regeneration: How Simple is Complex Enough?

A better understanding of the dynamic physical and biomolecular cues present in tissue microenvironments has led to a growing interest in the development of biomaterial systems for improved 3D culture environments, as well as delivery vehicles for cell-based therapies. As discovery of new biological signals and targets has evolved, so has the need for improved delivery systems to facilitate improvements in wound healing, stem cell engraftment, and reversal of fibrotic diseases. As a result, biomaterial scaffolds based on both protein components and highly tunable synthetic chemistries have evolved to address many of these needs. This talk will highlight several examples in which advances in four-dimensional control of scaffold properties can be used to better understand how to present and manipulate the presentation of biochemical signals, as well as to promote tissue regeneration.

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Plenary Lecture: Wednesday, July 16, 09:45 - 11:00

Moderator: Ruth Schmid

David Edwards is a pioneer of healthcare innovations at the crossroads of delivery science and contemporary design. The Professor of the Practice of Idea Translation at Harvard University and founding faculty member of the Wyss Institute, David’s early work in applied math and drug delivery led to advances in transdermal, cellular, and pulmonary drug and vaccine delivery innovations. More recently, David has pursued his innovations at Le Laboratoire, a public cultural center in Paris, and, from 2014, in Cambridge, Massachusetts, U.S.A. Among these are WikiFoods, functionally nutritious food forms designed around natural fruit structures, AeroLife, a line of functional nutrition products delivered into the mouth for ingestion via the air, and the oPhone, a portable convenient system for delivering complex olfactory messaging via global information networks. David has started the companies Advanced Inhalation Research, Pulmatrix, MEND, LabStore, Quantum Designs, and Vapor Communications, and won various awards including election to the U.S. and French National Academies of Engineering. For WikiFoods and AeroLife, David won separate international awards for best global innovation of the year at international food conferences in 2012 and 2013.

Redesigning Nutrition Delivery

The features of man-made delivery systems underlying the trillion-dollar food and beverage industry often contrast poorly with those of natural systems. Natural foods involve little or no environmental waste, encourage portion control, and efficiently deliver functional nutrition in mobile circumstances. These and other qualities, having insured the sustainable nourishment of animals and humans for many thousands of years, can be critically absent in today's food industry. This talk highlights the current revolution in the redesign of nutrition delivery aimed at meeting the health and environmental challenges of the 21st century. It especially highlights recent breakthroughs from our labs in the fields of aerosol foods and edible and biodegradable food packaging.

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Additional Invited Speakers

Mini Symposia

Scientific Sessions

Roundtable

Workshops

*Invited Speakers subject to change

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