CRS Inside Track
Current Inside Track Mimicking Circadian Rhythms Using Controlled Release Drug Delivery
By Andy Lewis, CRS Director-at-Large
Numerous circadian rhythms have been identified in humans that are controlled by the cyclical variation of various hormones. Far from simply concerning the sleep-wake cycle, an increasing number of physiological processes are known to follow such rhythms, including blood pressure, body temperature, drug metabolism, and pharmacokinetics to name but a few. Advances in controlled release drug delivery have opened up the possibility of developing formulations that exploit or mimic circadian rhythms to develop better treatments for patients. CRS Director-at-Large Andy Lewis interviewed Dr. Martin Whitaker (CEO of Diurnal Limited) on the concept of chronotherapeutics, the challenges faced in developing such products, and their clinical development.