Flt1 Peptide . Hyaluronic Acid Conjugate Micelle-Like NanoparticlesEncapsulating Genistein for the Treatment of Occular Neovascularization

Hyemin Kim1, Jun-Sub Choi2, Ki Su Kim 1, Jeong-A Yang 1, Choun-Ki Joo2, and Sei Kwang Hahn1*

1 Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), Korea; 2 Department of Opthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Korea

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Summary
Flt1 peptide - hyaluronic acid (HA) conjugate micellelike nanoparticles encapsulating genistein, an inhibitor of tyrosine-specific protein kinase, were developed for a combination therapy to treat ocular neovascularization. In vitro biological activity of the micelles was verified by the anti-proliferation of human umbilical vein endothelial cells (HUVECs). The corneal neovascularization in silver nitrate cauterized corneas of SD rats was significantly suppressed by the treatment with genistein/Flt1 peptide - HA micelles. The retinal vascular hyperpermeability was also drastically reduced in diabetic retinopathy model rats after treatment with the micelles.

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