Controlled Release of Bioactive PDGF-AA from PLGA Nanoparticles

Irja Elliott Donaghue1,2, Tasneem Zahir1,2, Molly S. Shoichet1,2,3
1Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada, 2Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario, M5S 3G9, Canada, 3Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6, Canada


Sustained, bioactive release of the oligodendrocyte differentiation factor PDGF-AA was achieved using PLGA nanoparticles dispersed in a hyaluronan/methyl cellulose hydrogel. The encapsulation and release was tuned by controlling protein loading and excipients. Delivery of this system in combination with neural stem/progenitor cells is a promising therapy for the treatment of spinal cord injury.

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