Multilayer alginate-chitosan microcapsules for the effective oral delivery of probiotic Bifidobacterium

M. T. Cook1, G. Tzortzis2, V. Khutoryanskiy1 and D. Charalampopoulos1
1 University of Reading, Reading, Berkshire, RG6 6AD, U.K.; 2,Clasado Ltd, Reading, Berkshire, RG6 6AD, U.K.


Many probiotic bacteria require additional formulation if they are to survive passage through the stomach after oral administration. Previous research has demonstrated the capability of alginate microcapsules to reduce the level of cell death associated with exposure to simulated gastric conditions [1]. In addition, chitosan has been shown to markedly improve the level of survival further. These formulations can also display a degree of time and pH dependent release in the gastrointestinal (GI) tract. Our current research focuses on the production of multilayer alginate-chitosan capsules as a means of improving the survival and release of these bacteria further, with the aim or improving the effectiveness of orally administered probiotics.

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