Target Specific Systemic Delivery of siRNA and Interferon a Using Gold Nanoparticles for the Treatment of Liver Diseases

Min-Young Lee1, Kitae Park2, Jeong-A Yang1, Sei Kwang Hahn1,2*

1 Department of Material Science & Engineering, 2 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Kyungbuk 790-784, Korea

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Summary
Gold nanoparticles (AuNPs) and hyaluronic acid (HA) have been extensively investigated for various drug delivery applications. In this work, we successfully developed a cysteamine modified AuNPs (AuCMs) / siRNA / polyethyleneimine (PEI) / HA complex using the layer-by-layer method for the target specific intracellular delivery of siRNA by HA receptor mediated endocytosis. In addition, interferon α (IFN α) and thiol end group functionalized HA (HA-SH) were complexed to AuNPs, which were successfully exploited for the target specific systemic treatment of hepatitis C virus infection. Taken together, we could confirm the feasibility of the smart nanomedicines using the hybrid materials of AuNPs and HA for the treatment of liver diseases.

 

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