S.E. Gilchrist1, D. Lange2, H. Bach3, L. Fazli2, Y. Av-Gay3, and H. Burt1
1Faculty of Pharmaceutical Sciences; 2Department of Urological Sciences; 3Division of Infectious Diseases; The University of British Columbia, Vancouver, BC, V6T1Z3, Canada
Here we report the development of a biodegradable localized nanofiber delivery system using poly(lactic acid-co-glycolic acid) (PLGA) for the combinatorial release of fusidic acid (FA) (or its sodium salt; SF) and rifampicin (RIF). All co-loaded formulations were continuous and defect-free, and allowed the controlled release of FA, SF, and RIF over 35d. The release of drug contents was sufficient to eliminate a number of pathogens associated with prosthetic joint infections, and prevented the colonization of methicillin-resistant S. aureus (MRSA) in vivo using a rodent model of implant infection.