Foam Hot Melt Extrusion of an Eudragit - Nifedipine Matrix Formulation using Supercritical CO2

T. Listro1, Tim Kane1, A. Adegoke2, A. Sarode2,3, P. Wang2,3
1Foster Corporation, 45 Ridge Road Putnam, CT 06260; 2Department of Chemical Engineering, University of Rhode Island, 3Department of Biomedical and Pharmaceutical Sciences, RI 02882

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Summary
Foam extrusion was investigated as a second generation of Hot Melt Extrusion (HME) technology to facilitate HME processing, improve the millablity of the extrudate, and further increase the API release rate. In this investigation, the release rate of poorly soluble drug Nifedipine was improved by hydrophilic polymer Eudragit EPO using Foam HME.

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