In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface charge

Tian Yua,c, Dallin Hubbardb,c, Abhijit Raya,c, Hamid Ghandeharia,b,c,*

a Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA, b Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA, c Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84108, USA

VIEW WEBCAST

Summary
The in vivo biodistribution, pharmacokinetics, and urinary and hepatic clearance of silica nanoparticles (SiO2) with systematically varied geometries, porosities, and surface charges were investigated in healthy CD-1 mice via the intravenous injection route (i.v.). Results showed that nanoparticle porosity and surface charge played a central role in determining the biodistribution pattern of SiO2.

 

© Copyright Controlled Release Society  | Contact Us - Report a Bad Link