Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus

Yuan Huang, Yun Jin, Yu-pin Song, Xi Zhu, Zhi-rong Zhang
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University. No. 17, Block 3, Southern Renmin Road, Chengdu 610041, P.R. China

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Summary
Goblet cell-targeting trimethyl chitosan nanoparticles conjugated with CSK peptide were prepared by multi ion crosslinked method with hydrophobic modification. Compared with single ion crosslinked nanoparticles, these nanoparticles showed improved stability, in combined with the targeting effects, led to the enhanced insulin transport across the mucus-secreting cell monolayer as well as the ligated ileum loop of rats. Finally, significant blood glucose depressions were found in diabetic rats.

 

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